Effects of Nigella sativa on Plasma Oxidative Stress,and Some Apoptotic Protein Markers in Cerebrum andHippocampus in Pentylenetetrazol-Induced Kindling Rats

Basit Öğe Kaydı
dc.contributor.authorÜstünova, Savaş
dc.contributor.authorMeral, İsmail
dc.contributor.authorKoçyiğit, Abdurrahim
dc.contributor.authorKılıç, Aysu
dc.contributor.authorZeybek, Öykü
dc.contributor.authorÜyüklü, Mehmet
dc.contributor.authorMeydan, Sedat
dc.date.accessioned2024-12-24T19:16:47Z
dc.date.available2024-12-24T19:16:47Z
dc.date.issued2020
dc.departmentSiirt Üniversitesi
dc.description.abstractObjective: This study was designed for investigating the effectiveness of the Nigella sativa (N. sativa) extract on apoptosis in cerebrum and hippocampus and also plasma oxidative stress, in pentylenetetrazol (PTZ)-induced kindling rats. Materials and Methods: The kindling model was induced by subconvulsive doses (35 mg/kg i.p.) of intraperitoneal PTZ injections in N. sativa treated and non-treated PTZ groups (PTZ and PTZ + NS). The PTZ + NS group were also treated with an extract of N. sativa (10 mg/kg) 2 h before each PTZ injection. The total oxidant and antioxidant status, oxidative stress index, paraoxonase, arylesterase, catalase (CAT) and total thiol levels were analyzed in plasma. Brain derived neurotrophic factor (BDNF), cyclin-B1 and B-cell lymphoma 2 (Bcl-2) expressions were investigated in the cerebrum and hippocampus.Results: PTZ decreased the oxidative stress by increasing the activities of CAT, arylesterase, and paraoxonase. N. sativadecreased activities of arylesterase, paraoxonase, while increasing the CAT. It also brought the decreased BDNF and Bcl-2 expression levels to their normal levels in the cerebrum but not in the hippocampus.Conclusion: N. sativa treatment improved the PTZ induced-impairments in BDNF and Bcl-2 expressions, resulting in a neuronal apoptosis in the cerebrum, without affecting blood oxidative stress.
dc.identifier.doi10.26650/EurJBiol.2020.0088
dc.identifier.endpage131
dc.identifier.issn2602-2575
dc.identifier.issn2618-6144
dc.identifier.issue2
dc.identifier.startpage124
dc.identifier.trdizinid461988
dc.identifier.urihttps://doi.org/10.26650/EurJBiol.2020.0088
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/461988
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4599
dc.identifier.volume79
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofEuropean Journal of Biology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectTıbbi Araştırmalar Deneysel,Nörolojik Bilimler
dc.titleEffects of Nigella sativa on Plasma Oxidative Stress,and Some Apoptotic Protein Markers in Cerebrum andHippocampus in Pentylenetetrazol-Induced Kindling Rats
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu