The protective effects of Selenium and Boron against Cyclophosphamide-induced bone marrow and blood toxicity: An in vivo study

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dc.contributor.authorAyhancı, Adnan
dc.contributor.authorLafcı, Nilüfer
dc.contributor.authorMusmul, Ahmet
dc.contributor.authorGür, Fatma Özabacıgil
dc.contributor.authorSezer, Canan
dc.contributor.authorSahin, İlknur Kulcanay
dc.contributor.authorGür, Bahri
dc.date.accessioned2024-12-24T19:18:08Z
dc.date.available2024-12-24T19:18:08Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractThanks to their antioxidant, anti-apoptotic, anti-lipid peroxidative, and immune-boosting properties, Boron (B) and Selenium (Se) are essential trace elements for the human body. This study aims to compare the myeloid protective potentials of Se and B in Cyclophosphamide (CP)-induced bone-marrow and haematological toxicity in experimental rats considering that the myelotoxic property of this anti-cancer drug limits its use. We hypothesized that selenium has a better protective effect than boron in preventing the toxic effects of CP on bone marrow and blood cells. 1.5 mg/kg of Se and 20 mg/kg of B, which are the most frequently used optimal doses of these trace elements, were given to the animals intraperitoneally throughout the experiment. 200 mg/kg of CP was administered only on the 4th day. The animals were sacrificed to take the blood and bone marrow samples to be stored for hematological evaluations. The CP administration significantly decreased leukocyte (WBC), thrombocyte (PLT), erythrocytes (RBC), and bone marrow nucleated cell counts. On the other hand, they increased in significant amounts in the groups given Se and B along with CP when compared to those given only CP. However, Se proved to be more protective than B in preventing CP-induced bone marrow and hematologic toxicity despite not achieving statistical significance. It was, therefore, concluded that the doses used in this experiment were successful in protecting against CP-induced damage to the bone marrow and CP-related hematological toxicity.
dc.identifier.doi10.46309/biodicon.2022.1124346
dc.identifier.endpage264
dc.identifier.issn1308-5301
dc.identifier.issn1308-8084
dc.identifier.issue2
dc.identifier.startpage256
dc.identifier.trdizinid1118559
dc.identifier.urihttps://doi.org/10.46309/biodicon.2022.1124346
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1118559
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4971
dc.identifier.volume15
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofBiological Diversity and Conservation
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectCyclophosphamide
dc.subjectBoron
dc.subjectSelenium
dc.subjectBone marrow
dc.subjectHematologic toxicity
dc.titleThe protective effects of Selenium and Boron against Cyclophosphamide-induced bone marrow and blood toxicity: An in vivo study
dc.typeArticle

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