Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial and DNA binding activities. Turkish Journal of Chemistry
| dc.contributor.author | Gümüş, Ayşegül | |
| dc.contributor.author | Okumuş, Veysi | |
| dc.contributor.author | Gümüş, Selçuk | |
| dc.date.accessioned | 2019-11-28T16:07:47Z | |
| dc.date.available | 2019-11-28T16:07:47Z | |
| dc.date.issued | 2018 | en_US |
| dc.department | Fen - Edebiyat Fakültesi | en_US |
| dc.description.abstract | 2-Substituted 8-propargyloxyquinoline derivatives have been synthesized from 2-substituted-8-hydroxyquinolines by O-propargylation method (30%–98% yields). The newly synthesized compounds were tested for in vitro antioxidant activities such as DPPH radical scavenging, ferrous chelating, and reducing power activities. The maximum radical scavenging (46.5%) and reducing power activities were obtained from 1 and maximum ferrous chelating effect was obtained from 6 (72.1%) at the concentration of 500 g/mL. To indicate DNA binding activity of the complexes calf thymus DNA was used. The compounds were also evaluated for their antimicrobial activity against three gram-positive and three gram-negative bacteria. Compounds 3 and 5 exhibited antibacterial activity against all tested gram-positive bacteria. | en_US |
| dc.description.provenance | Submitted by Veysi OKUMUŞ (veysiokumus@siirt.edu.tr) on 2019-11-28T16:07:47Z No. of bitstreams: 1 A33.pdf: 717065 bytes, checksum: 6da4ff2413d59553b55cc7f9320dc748 (MD5) | en |
| dc.description.provenance | Made available in DSpace on 2019-11-28T16:07:47Z (GMT). No. of bitstreams: 1 A33.pdf: 717065 bytes, checksum: 6da4ff2413d59553b55cc7f9320dc748 (MD5) Previous issue date: 2018 | en |
| dc.identifier.endpage | 1369 | en_US |
| dc.identifier.issue | 42 | en_US |
| dc.identifier.startpage | 1358 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12604/2010 | |
| dc.language.iso | other | en_US |
| dc.relation.ispartof | Turkish Journal of Chemistry | |
| dc.relation.publicationcategory | Makale - Uluslararası - Editör Denetimli Dergi - Başka Kurum Yazarı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.snmz | #KayıtKontrol# | |
| dc.subject | Quinoline, propargyloxyquinoline, antioxidant, antibacterial, DNA binding activity | en_US |
| dc.title | Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial and DNA binding activities. Turkish Journal of Chemistry | en_US |
| dc.type | Article | en_US |
