Bacillus Calmette Guerin (BCG) Immunotherapy for Bladder Cancer: A Control and Mathematical Analysis

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dc.contributor.authorAkgül, Ali
dc.contributor.authorFarman, Muhammad
dc.contributor.authorAhmad, Aqeel
dc.contributor.authorSaleem, Muhammad Umer
dc.date.accessioned2024-12-24T19:10:15Z
dc.date.available2024-12-24T19:10:15Z
dc.date.issued2021
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this manuscript, Immunotherapy with Bacillus Calmette Guerin (BCG) vaccine is devised for treating spherical bladder cancer. We considered the cancer model regarding tumor-immune connections in the bladder as a result of BCG therapy and check the input and output of the system. Controllability and observability are treated for the logistic model and exponential model for cancer according to parameter values. Consider the system for stability investigation about the point of equilibrium and taking Bacillus Calmette Guerin (BCG) vaccine concentration as an input and effector cells are output in the system under consideration. The model clarifies that the concentration of immunotherapy should be held in prescribed limits. Also, numerical simulations are carried of the proposed techniques to show the actual behavior of the system to support the biological results. © 2021, The Author(s), under exclusive licence to Springer Nature India Private Limited.
dc.identifier.doi10.1007/s40819-021-01191-3
dc.identifier.issn2349-5103
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85119980209
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org10.1007/s40819-021-01191-3
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4021
dc.identifier.volume7
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Journal of Applied and Computational Mathematics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectBCG immunotherapy
dc.subjectCancer model
dc.subjectControllability
dc.subjectObservability
dc.subjectStability analysis
dc.titleBacillus Calmette Guerin (BCG) Immunotherapy for Bladder Cancer: A Control and Mathematical Analysis
dc.typeArticle

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