Effect of resveratrol on the changes in the cerebellum in traumatic brain injury

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dc.contributor.authorFiridin, Mustafa Nevzat
dc.date.accessioned2024-12-24T19:10:22Z
dc.date.available2024-12-24T19:10:22Z
dc.date.issued2021
dc.departmentSiirt Üniversitesi
dc.description.abstractOBJECTIVE: To study the effects of resveratrol in neuronal structures in traumatic brain injury (TBI). STUDY DESIGN: Thirty rats were categorized as (1) control group (n=10), saline solution administered i.p. for 14 days, (2) TBI group (n=10), trauma induced by weight-drop model on brain, and (3) TBI+Resveratrol group (n=10), 15 minutes after injury the rats were given resveratrol (10 ?moL/kg/i.p.) for 14 days. At the end of the experiment the cerebellum was excised for routine paraffin tissue protocol. Blood samples were tested for serum biochemical markers (MDA, SOD, CAT, and GSH-x). RESULTS: SOD, GPx, and CAT values were lowest in the TBI group. MDA and histological scores of dilations in vessels, inflammation, degeneration in neurons, apoptosis in microglia, ADAMTS8, and GFAP expressions were highest in the TBI group. Sections of the control group showed normal cerebellar histology. The trauma group showed degenerated ganglion layer, pyknotic and apoptotic Purkinje cell nuclei. Vascular thrombus was seen in the substantia alba and substantia grisea. In the Trauma+Resveratrol group, most pathologies observed in the TBI group were improved. In the control group, GFAP protein was expressed in granular cells, axons, dendrites, Purkinje cells, and microglia cells. In the trauma group, increased GFAP expression was observed in glial processes, neurons, and Purkinje cells. In the Trauma+Resveratrol group, GFAP was expressed in molecular layer and glial processes. In the control group, ADAMTS-4 activity was observed in granulosa layer, glial cells, and Purkinje cells. In the trauma group, ADAMTS-4 expression was positive in Purkinje cells and glial cells. In the Trauma+ Resveratrol group, ADAMTS-4 was expressed in Purkinje cells, granular cells, and glial cells. CONCLUSION: GFAP and ADAMTS-4 proteins may be involved in regeneration of damaged astroglial cells and other glial cells, Purkinje cells, and synaptic extensions. We suggest that antioxidative drugs such as resveratrol may be alternative target agents in neurological disease. © Science Printers and Publishers, Inc.
dc.identifier.endpage201
dc.identifier.issn2578-742X
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85119470260
dc.identifier.scopusqualityN/A
dc.identifier.startpage193
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4085
dc.identifier.volume43
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherScience Printers and Publishers Inc.
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectADAMTS-4
dc.subjectBrain
dc.subjectCerebellum
dc.subjectGFAP
dc.subjectRat
dc.subjectResveratrol
dc.subjectTraumatic brain injury
dc.titleEffect of resveratrol on the changes in the cerebellum in traumatic brain injury
dc.typeArticle

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