Investigation of Some Pesticides’ Effects on Activities of Glutathione Reductase and Glutathione S-Transferase Purified from Turkey Liver under in Vitro Conditions

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dc.contributor.authorGüller, Pınar
dc.contributor.authorAkkemik, Ebru
dc.contributor.authorKör, Sevil
dc.contributor.authorÇiftçi, Mehmet
dc.date.accessioned2024-12-24T19:16:36Z
dc.date.available2024-12-24T19:16:36Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractWhereas a very small amount of pesticides which are used for elimination of undesirable speciesand for a more fertile agriculture reach the target organism, majority of pesticides reach to nontarget organisms. It isforeseen by our team that the pesticides used for various purposes may negatively affect the glutathione mechanismof the organisms. However, determination of effective dosage range is the objective of our study subjects. For thisreason, the in vitro effects of widely used pesticides (lambda-cyhalothrin, cypermethrin, chlorpyrifos, dichlorvos,glyphosate isopropylamine) on the activities of glutathione reductase (GR) and glutathione S-transferase(GST) which are two important enzymes of the glutathione system have been investigated in this study. It hasbeen determined that when lambda-cyhalothrin does not affect the GR enzyme purified from the turkey liver,chlorpyrifos, glyphosate isopropylamine, dichlorvos and cypermethrin cause inhibition. When the effects ofpesticides on GST enzyme purified from turkey liver were investigated in in vitro conditions, it was determinedthat all examined pesticides had inhibitory effects. In this context, the potential doses which can create a risk forlive life, of pesticides that are commonly used, have been identified.
dc.identifier.doi10.21597/jist.458632
dc.identifier.endpage217
dc.identifier.issn2146-0574
dc.identifier.issn2536-4618
dc.identifier.issue3
dc.identifier.startpage211
dc.identifier.trdizinid290794
dc.identifier.urihttps://doi.org/10.21597/jist.458632
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/290794
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4486
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofIğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectKimya
dc.subjectTıbbi,Çevre Bilimleri
dc.titleInvestigation of Some Pesticides’ Effects on Activities of Glutathione Reductase and Glutathione S-Transferase Purified from Turkey Liver under in Vitro Conditions
dc.typeArticle

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