Influence of pesticides on the pH regulatory enzyme, carbonic anhydrase, from European Seabass liver and bovine erythrocytes

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dc.contributor.authorDemirdag, Ramazan
dc.contributor.authorYerlikaya, Emrah
dc.contributor.authorAksakal, Ercüment
dc.contributor.authorKufrevioglu, Omer Irfan
dc.contributor.authorEkinci, Deniz
dc.date.accessioned2019-11-18T10:31:49Z
dc.date.available2019-11-18T10:31:49Z
dc.date.issued2012
dc.departmentBelirleneceken_US
dc.description.abstractThe objective of this study was to assess the inhibitory effects of six commonly used pesticides, cyhalothrin, cypermethrin, dichlorvos, methamidophos, chlorpyrifos and methylparathion, on the pH regulatory enzyme carbonic anhydrase (CA) of Dicentrarchus labrax (European Seabass) liver (dCA) and bovine erythrocytes (bCA). Results of the study showed that the pesticides displayed quite variable inhibition profiles with KI values ranging from 0.376 to 26.164 M against dCA, and from 1.174 to 53.281 M against bCA. Methyl- parathion was the most effective inhibitor for both enzymes. Overall data show that all of the tested pesticides inhibit both dCA and bCA at low concentrations indicating that indiscriminate use of these pesticides might cause disruption of acid base regulation resulting in animal deaths. Our results also point out that susceptibility to these pesticides varies among CAs from different organisms.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12604/1614
dc.language.isoenen_US
dc.relation.publicationcategoryUlusal Hakemli Dergi Makalesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz#KayıtKontrol#
dc.subjectCA, Purification, Organophosphate, Pesticide, Inhibitionen_US
dc.titleInfluence of pesticides on the pH regulatory enzyme, carbonic anhydrase, from European Seabass liver and bovine erythrocytesen_US
dc.typeArticleen_US

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