Effects of pro-inflammatory interleukin-6 and anti-inflammatory interleukin-10 cytokines in pregnant women diagnosed with coronavirus disease 2019

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dc.contributor.authorGöklü, Mehmet Rifat
dc.contributor.authorTunç, Şeyhmus
dc.contributor.authorAksin, Şerif
dc.contributor.authorAndan, Cengiz
dc.date.accessioned2024-12-24T19:16:38Z
dc.date.available2024-12-24T19:16:38Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractAim: This study aims to investigate the relationship between serum interleukin (IL)-6 and IL-10 levels in coronavirus disease (COVID)-19 positive pregnant women and the course of the disease. Methods: In our study, serum IL-6 and IL-10 levels were measured in 28 third-trimester COVID- 19-positive pregnant women and 30 third-trimester healthy pregnant women. COVID-19-positive cases were classified as carriers or patients. While 13 of the pregnant women in the study group were asymptomatic or were being followed out due to mild illness; a total of 15 pregnant women, 7 of whom were in the intensive care unit (ICU), were hospitalized and treated. IL-6 and IL-10 tests of COVID-19-positive pregnant women were studied at the time of first application. Results: Seven (25%) patients with COVID-19 required admission to an ICU. The IL-6 level was found to be significantly lower in COVID-19-negative pregnant women compared to pregnant women who were COVID-19 carriers and patients (p=0.01). The IL-10 level was found to be signifi- cantly higher in pregnant women who were negative for COVID-19 compared to pregnant women who were COVID-19 carriers (p=0.002) and patients (p=0.002). Conclusion: Close monitoring of IL-6 and IL-10 cytokine levels is recommended to minimize the risk of adverse outcomes in pregnant women presenting with a suspected or confirmed diagnosis of COVID-19. In this way, it may be possible to distinguish moderate–mild COVID-19 from severe COVID-19 in pregnant women.
dc.identifier.doi10.21673/anadoluklin.1129488
dc.identifier.endpage274
dc.identifier.issn2149-5254
dc.identifier.issn2458-8849
dc.identifier.issue3
dc.identifier.startpage268
dc.identifier.trdizinid1134823
dc.identifier.urihttps://doi.org/10.21673/anadoluklin.1129488
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1134823
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4515
dc.identifier.volume27
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofANADOLU KLİNİĞİ TIP BİLİMLERİ DERGİSİ
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectCOVID-19
dc.subjectpregnancy
dc.subjectinterleukin-6
dc.subjectinterleukin-10
dc.titleEffects of pro-inflammatory interleukin-6 and anti-inflammatory interleukin-10 cytokines in pregnant women diagnosed with coronavirus disease 2019
dc.typeArticle

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