ACUTE AND LONG-TERM PATHOLOGICAL EFFECTS OF COVID-19 ON THE PLACENTA DURING SECOND TRIMESTER AND LABOR

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dc.authoridyilmaz, mehmet/0000-0002-9930-4156
dc.contributor.authorTast, Fatih
dc.contributor.authorErdemci, Fikri
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorAsir, Firat
dc.contributor.authorOzudogru, Osman
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-12-24T19:33:48Z
dc.date.available2024-12-24T19:33:48Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractBackground: COVID-19 pandemic has affected all the world. The consequence of the COVID-19 infection causes many disorders in many organs, one of them is the placenta. COVID-19 disease has long-term effects on various tissues after recovery. The aim of this study was to investigate the placentas of pregnant women with healthy, COVID-19 positive during the second trimester and labor. Material and methods: A total of twenty-four pregnant women (8 patients per each group) were included in the study. Their placentas were processed for routine paraffin wax embedding protocol. The blood parameters of patients were recorded. Placental tissues were stained with hematoxylin-eosin dye and immune stained with TNF-a and ADAMTS-8. Statistical analysis was performed on blood and histological parameters.Results: AST and CRP values of biochemical parameters were higher in women with second trimester and labor groups than in the healthy group. Also, a significant increase in ALT values was observed in the labor group. Normal histology was observed in the placentas of healthy patients. More histopathology was recorded in the placentas of COVID-19 infected women compared to healthy placentas. The expression of TNF-a and ADAMTS-8 were found significantly higher in the COVID-19 placentas compared to the non-COVID-19 group.Conclusions: COVID-19 infection can cause pathological changes during pregnancy and labor. This study shows that COVID-19 not only acutely has adverse effects on placental pathologies but also has long-term effects. TNF-a and ADAMTS-8 primary antibodies can be a guide in demonstrating these effects.
dc.identifier.doi10.33975/riuq.vol35n1.1154
dc.identifier.endpage235
dc.identifier.issn1794-631X
dc.identifier.issn2500-5782
dc.identifier.issue1
dc.identifier.startpage228
dc.identifier.urihttps://doi.org/10.33975/riuq.vol35n1.1154
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8303
dc.identifier.volume35
dc.identifier.wosWOS:000996039000018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherUniv Quindio
dc.relation.ispartofRevista De Investigaciones-Universidad Del Quindio
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectADAMTS-8
dc.subjectCovid-19
dc.subjectplacenta
dc.subjectTNF-alpha
dc.titleACUTE AND LONG-TERM PATHOLOGICAL EFFECTS OF COVID-19 ON THE PLACENTA DURING SECOND TRIMESTER AND LABOR
dc.typeArticle

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