Investigation of In Vivo Effects of Carbon Tetrachloride (CCl4) and Quercetin on Some Metabolic Enzyme Activities in Rat Erythrocyte

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dc.contributor.authorTemel, Yusuf
dc.contributor.authorAkkoyun, Mahire Bayramoğlu
dc.contributor.authorAkkoyun, H. Turan
dc.contributor.authorBengü, Aydın Şükrü
dc.contributor.authorKaragözoğlu, Fatma
dc.date.accessioned2024-12-24T19:18:09Z
dc.date.available2024-12-24T19:18:09Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractIn the study; the purpose was to investigate the in vivoimpact of carbon tetrachloride (CCl4)andquercetin(Qu)onactivitiesofimportantmetabolicenzymessuchasGlucose6-phosphatedehydrogenase(G6PD),6-phosphogluconatedehydrogenase(6PGD),glutathione reductase(GR)andglutathioneS-transferase(GST)inraterythrocytes. Attheexperimental stage,ratsweredividedinto4groups.1.Group(Control):Pureoliveoilatadosedetermined according to their body weight (1mL/kg) was given to the rats in this group, 2.Group (CCl4: 1.0 mL/kg(ip)(1:1),3.Group(Ku:25)mg/kg(ip),4.Group(CCl4(1.0ml/kg(ip)+Ku(25mg/kg (ip) was injected. The study was continued for 3 days.The results revealed that the activities of; G6PD (p?0.01),6PGD(p?0.01),GR(p?0.001)andGST(p?0.05)enzymeactivitieswere decreasedintheCCl4groupcomparedtothecontrolgroup.Itwasdeterminedthatenzyme activitieswerehigher in CCl4+Qu applied groups compared to CCl4group.Theapplication of Qu caused an increase in theenzyme activity value. This can be accepted as an indication that theinhibitioncausedbyCCI4hasdisappeared.Consequently;ItisthoughtthatQumaybe effective in preventing oxidative damage due to CCl4administration.
dc.identifier.doi10.46810/tdfd.1036416
dc.identifier.endpage128
dc.identifier.issn2149-6366
dc.identifier.issue1
dc.identifier.startpage123
dc.identifier.trdizinid1069512
dc.identifier.urihttps://doi.org/10.46810/tdfd.1036416
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1069512
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4981
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTürk Doğa ve Fen Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectGlutatyon S-transferaz
dc.subjectCarbon tetrachloride
dc.subjectGlutathione reductase
dc.subject6-phosphogluconate dehydrogenase
dc.subjectQuercetin
dc.subjectGlucose 6-phosphate dehydrogenase
dc.titleInvestigation of In Vivo Effects of Carbon Tetrachloride (CCl4) and Quercetin on Some Metabolic Enzyme Activities in Rat Erythrocyte
dc.typeArticle

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