Thyroid Function Tests and Thyroid Antibody Tests in Ectopic Pregnancies: A Prospective Cohort Study

dc.contributor.authorAksin, Şerif
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorBalsak, Deniz
dc.contributor.authorAboalhasan, Yasmin
dc.contributor.authorYoldaş, Adem
dc.contributor.authorBatmaz, İbrahim
dc.date.accessioned2024-12-24T19:10:00Z
dc.date.available2024-12-24T19:10:00Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractThyroid hormone levels have been observed to induce structural changes in different regions of the fallopian tube. This study aimed to investigate the impact of thyroid hormones on ectopic pregnancy. In pursuit of this objective, 31 patients with ectopic pregnancy were monitored at Siirt University Training and Research Hospital between July 2022 and December 2022. Additionally, a total of 31 patients with normal first-trimester pregnancies, matched for age, parity, and gestational week, were included in th e control group. Various parameters, including patient age, pregnancy history, medical history, treatment methods, clinical and demographic data, TSH, fT3, fT4, TT3, TT4, Thyroglobulin, Anti-thyroglobulin Antibody, TSH receptor antibody (TrAB), Anti-Peroxidase Antibody, Anti-Tyroglobulin Antibody, hemogram, biochemistry, CRP, and sedimentation values, were compared.Clinical Trials no: NCT05446012 Statistically significant differences were noted in Free T3 (p = 0.011) and thyroglobulin (p = 0.018) values bet ween the ectopic pregnancy and control groups. Subsequent ROC analysis was conducted for the significant parameters, determining the AUC (Lower and Upper Bound), sensitivity, specificity, and cut-off values for each parameter. Multivariate logistic regression analysis followed, wherein the "backward stepwise model" was applied to the Free T3 parameter. The apparent parameter indicating an increased risk in the disease was Free T3, with a 4.2-fold increase and a 95% CI of [1.3-13.5]. Lower Free T3 levels were associated with an elevated risk of ectopic pregnancy. The assessment of Free T3 levels during pre-pregnancy counseling may aid in identifying pregnant women at risk of ectopic pregnancy. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
dc.identifier.doi10.5505/ejm.2024.65768
dc.identifier.endpage502
dc.identifier.issn1301-0883
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85208424331
dc.identifier.scopusqualityQ4
dc.identifier.startpage494
dc.identifier.urihttps://doi.org10.5505/ejm.2024.65768
dc.identifier.urihttps://hdl.handle.net/20.500.12604/3892
dc.identifier.volume29
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherYuzuncu Yil Universitesi Tip Fakultesi
dc.relation.ispartofEastern Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectEctopic
dc.subjecthormones
dc.subjectpregnancy
dc.subjectthyroid
dc.titleThyroid Function Tests and Thyroid Antibody Tests in Ectopic Pregnancies: A Prospective Cohort Study
dc.typeArticle

Dosyalar