The Synthetic Elicitor 2-(5-Bromo-2-Hydroxy-Phenyl)- Thiazolidine-4-Carboxylic Acid Links Plant Immunity to Hormesis

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dc.contributor.authorRODRIGUEZ-SALUS, MELINDA
dc.contributor.authorBEKTAS, YASEMÄ°N
dc.contributor.authorSCHROEDER, MERCEDES
dc.contributor.authorKNOTH, COLLEEN
dc.contributor.authorVU, TRANG
dc.contributor.authorROBERTS, PHILIP
dc.contributor.authorKALOSHIAN, ISGOUHI
dc.contributor.authorEULGEM, THOMAS
dc.date.accessioned2019-11-18T09:02:39Z
dc.date.available2019-11-18T09:02:39Z
dc.date.issued2016
dc.departmentBelirleneceken_US
dc.description.abstractSynthetic elicitors are drug-like compounds that induce plant immune responses but are structurally distinct from natural defense elicitors. Using high-throughput screening, we previously identified 114 synthetic elicitors that activate the expression of a pathogen-responsive reporter gene in Arabidopsis (Arabidopsis thaliana). Here, we report on the characterization of one of these compounds, 2-(5-bromo-2-hydroxy-phenyl)-thiazolidine-4-carboxylic acid (BHTC). BHTC induces disease resistance of plants against bacterial, oomycete, and fungal pathogens and has a unique mode of action and structure. Surprisingly, we found that low doses of BHTC enhanced root growth in Arabidopsis, while high doses of this compound inhibited root growth, besides inducing defense. These effects are reminiscent of the hormetic response, which is characterized by low-dose stimulatory effects of a wide range of agents that are toxic or inhibitory at higher doses. Like its effects on defense, BHTC-induced hormesis in Arabidopsis roots is partially dependent on the WRKY70 transcription factor. Interestingly, BHTC-induced root hormesis is also affected in the auxin-response mutants axr1-3 and slr-1. By messenger RNA sequencing, we uncovered a dramatic difference between transcriptional profiles triggered by low and high doses of BHTC. Only high levels of BHTC induce typical defenserelated transcriptional changes. Instead, low BHTC levels trigger a coordinated intercompartmental transcriptional response manifested in the suppression of photosynthesis- and respiration-related genes in the nucleus, chloroplasts, and mitochondria as well as the induction of development-related nuclear genes. Taken together, our functional characterization of BHTC links defense regulation to hormesis and provides a hypothetical transcriptional scenario for the induction of hormetic root growth.en_US
dc.description.sponsorshipThis work was supported by the National Science Foundation (grant no. IOS–1313814 to T.E. and ChemGen IGERT program predoctoral fellowships to M.R.-S., M.S., and C.K.) and by the Turkish Republic Ministry of National Education (predoctoral fellowship to Y.B.)en_US
dc.identifier.citationRodriguez-Salus, M., Bektas, Y., Schroeder, M., Knoth, C., Vu, T., Roberts, P., ... & Eulgem, T. (2016). The synthetic elicitor 2-(5-bromo-2-hydroxy-phenyl)-thiazolidine-4-carboxylic acid links plant immunity to hormesis. Plant physiology, 170(1), 444-458.en_US
dc.identifier.urihttp://www.plantphysiol.org/content/170/1/444
dc.identifier.urihttps://hdl.handle.net/20.500.12604/1609
dc.language.isoenen_US
dc.publisherPLANT PHYSIOLOGYen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergi Makalesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz#KayıtKontrol#
dc.titleThe Synthetic Elicitor 2-(5-Bromo-2-Hydroxy-Phenyl)- Thiazolidine-4-Carboxylic Acid Links Plant Immunity to Hormesisen_US
dc.typeArticleen_US

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