THE EFFECT OF FUCOIDAN ON THE GENTAMICIN INDUCED NEPHROTOXICITY IN RATS

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dc.authoridYILMAZ, MESUT/0000-0002-5950-8496
dc.contributor.authorYilmaz, Mesut
dc.contributor.authorMert, Handan
dc.contributor.authorIrak, Kivanc
dc.contributor.authorErten, Remzi
dc.contributor.authorMert, Nihat
dc.date.accessioned2024-12-24T19:33:28Z
dc.date.available2024-12-24T19:33:28Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractPossible preventive or therapuetic effects of fuciodan, which has antioxidant properties and was administered together with gentamicin (GM) made up nephrotoxicity through giving GM to the rats, have been searched. The rats used in this study were randomly grouped in three: control, GM (80 mg/kg/day/i.p GM was administered for 8 days), GM+fucoidan (80 mg/kg/day/i.p GM for 8 days + fucoidan 100 mg/kg/day/ for 8 days were administered with intra-gastric gavage) groups. Blood and tissue samples were taken 24 hours after the 8 days trial period. Besides determining plasma creatinine, BUN, sodium, potassium, chloride levels in auto-analyser, whole blood glutathione, plasma MDA and AOPP levels were analyzed spectrophotometrically. The highest plasma creatinine, BUN, potassium, AOPP and MDA levels were found in the GM group. It was determined that while the levels of creatinin (p<0.01), BUN (p<0.05), potassium (p<0.05), AOPP (p<0.01), MDA (p<0.01) in GM+fucoidan group were decreasing with regard to those in GM group, chloride levels were rising (p<0.05). The study revealed the nephroprotective effect of fucoidan. These findings suggest that fucoidan administration together with GM may attenuate renal dysfunction and structural damage through the reduction of oxidative stress in the kidney.
dc.description.sponsorshipVan YYU Directory of Scientific Research Project [2012-SBE-YL003]
dc.description.sponsorshipThis research was supported by the Van YYU Directory of Scientific Research Project as 2012-SBE-YL003 Project number. The study has been orally presented and published as abstract in the 8th National Veterinary Biochemistry and Clinical Biochemistry Congress 22-24 September 2016, Bursa, Turkey.
dc.identifier.endpage2241
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue4
dc.identifier.startpage2235
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8134
dc.identifier.volume27
dc.identifier.wosWOS:000430372900032
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectgentamicin
dc.subjectfucoidan
dc.subjectAOPP
dc.subjectGSH
dc.subjectMDA
dc.titleTHE EFFECT OF FUCOIDAN ON THE GENTAMICIN INDUCED NEPHROTOXICITY IN RATS
dc.typeArticle

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