Enantioselective installation of quaternary centers in cyclic oxonitriles
| dc.authorid | https://orcid.org/0000-0002-3967-8404 | en_US |
| dc.contributor.author | Güneş, Yakup | |
| dc.contributor.author | Arçelik, Nejat | |
| dc.contributor.author | Şahin, Ertan | |
| dc.contributor.author | Fleming, Fraser F. | |
| dc.contributor.author | Altundaş, Ramazan | |
| dc.date.accessioned | 2019-12-23T06:55:44Z | |
| dc.date.available | 2019-12-23T06:55:44Z | |
| dc.date.issued | 2015 | en_US |
| dc.department | Eğitim Fakültesi | en_US |
| dc.description.abstract | Quaternary centers are rapidly and selectively installed in a series of seven-membered and bridged cyclic oxonitriles through conjugate addition of an alkoxide to chloroalkenenitriles, followed by a Claisen rearrangement. Using this strategy, the stereogenic information of the carbinol in secondary allylic alcohols is transferred to the newly generated quaternary center. Experimentally, the sequence rapidly gives alkyl cyanocycloheptanones and bicycloalkanonecarbonitriles in good yield and with high selectivity, in a single synthetic operation. | en_US |
| dc.identifier.citation | Gunes, Y., Arcelik, N., Sahin, E., Fleming, F. F., & Altundas, R. (2015). Enantioselective Installation of Quaternary Centers in Cyclic Oxonitriles. European Journal of Organic Chemistry, 2015(30), 6679-6686. | en_US |
| dc.identifier.doi | 10.1002/ejoc.201500895 | |
| dc.identifier.endpage | 6686 | en_US |
| dc.identifier.issn | 1434193X | |
| dc.identifier.startpage | 6679 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12604/2346 | |
| dc.identifier.volume | 30 | en_US |
| dc.institutionauthor | Güneş, Yakup | |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley-VCH Verlag | en_US |
| dc.relation.ispartof | European Journal of Organic Chemistry | |
| dc.relation.publicationcategory | Makale - Uluslararası - Editör Denetimli Dergi | en_US |
| dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.snmz | #KayıtKontrol# | |
| dc.subject | Alkylation | en_US |
| dc.subject | Asymmetric synthesis | en_US |
| dc.subject | Rearrangement | en_US |
| dc.subject | Sigmatropic rearrangement | en_US |
| dc.subject | Synthetic methods | en_US |
| dc.title | Enantioselective installation of quaternary centers in cyclic oxonitriles | en_US |
| dc.type | Article | en_US |
