Mechanistic review of melatonin metabolism and signaling pathways in plants: Biosynthesis, regulation, and roles under abiotic stress

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dc.contributor.authorIkram, Muhammad
dc.contributor.authorMehran, Muhammad
dc.contributor.authorRehman, Haseeb ur
dc.contributor.authorUllah, Shafi
dc.contributor.authorBakhsh, Muhammad Zeeshan Mola
dc.contributor.authorTahira, Maryam
dc.contributor.authorMaqsood, Muhammad Faizan Khurram
dc.date.accessioned2024-12-24T19:10:23Z
dc.date.available2024-12-24T19:10:23Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractMelatonin, a multifunctional biomolecule found in animals and plants, is critical in regulating various physiological processes. In plants, melatonin biosynthesis primarily originates from tryptophan through multiple enzymatic steps, finely controlled by different environmental and endogenous factors. This review synthesizes current knowledge on melatonin biosynthesis, production levels, and signaling mechanisms, focusing on its role in plant stress responses. Research shows that melatonin mitigates abiotic stresses such as drought, salinity, and temperature extremes by enhancing antioxidant systems, scavenging reactive oxygen species, and modulating ion homeostasis. Additionally, melatonin signaling, which may involve the mitogen-activated protein kinase (MAPK) cascade and potentially the Cand2 receptor (though its role remains debated), is essential for promoting plant growth and enhancing stress tolerance. This review also examines the potential of targeting specific enzymes, such as tryptamine 5-hydroxylase (T5H), to create melatonin knockout mutants, offering new insights into the regulatory networks of melatonin-mediated stress responses. The review concludes by identifying future research directions, particularly in understanding the complex cross-talk within melatonin signaling pathways and the debated role of Cand2 in plant resilience. © 2024 The Author(s)
dc.description.sponsorshipBahauddin Zakariya University
dc.identifier.doi10.1016/j.stress.2024.100685
dc.identifier.issn2667-064X
dc.identifier.scopus2-s2.0-85210134715
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org10.1016/j.stress.2024.100685
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4087
dc.identifier.volume14
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofPlant Stress
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectAbiotic stress
dc.subjectBiosynthesis
dc.subjectCand2
dc.subjectMAPK
dc.subjectMelatonin
dc.subjectT5H
dc.titleMechanistic review of melatonin metabolism and signaling pathways in plants: Biosynthesis, regulation, and roles under abiotic stress
dc.typeReview Article

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