Mathematical modeling for enzyme inhibitors with slow and fast subsystems

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dc.contributor.authorAkgül, Ali
dc.contributor.authorKhoshnaw, Sarbaz H. A.
dc.contributor.authorAbdalrahman, Awder S.
dc.date.accessioned2024-12-24T19:10:20Z
dc.date.available2024-12-24T19:10:20Z
dc.date.issued2020
dc.departmentSiirt Üniversitesi
dc.description.abstractMathematical modeling for biochemical enzyme inhibitor systems plays an important role in the systems of biology. Studying and analyzing the dynamical behavior for such models often need some techniques to obtain the model reduction. The well-known techniques of model reduction are suggested in order to divide the model equations into slow and fast subsystems. They are quasi steady-state approximation and quasi-equilibrium approximation. These techniques are great mathematical tools for simplifying model equations and identifying some analytical approximate solutions. In this work, we define mathematical models of enzyme inhibitors and suggest the model reduction approaches. We study two models as examples for enzyme inhibitors such as competitive inhibition and uncompetitive inhibition. Obtained results show that the suggested approaches are effective tools to minimize the number of elements and to find analytical approximate solutions. Accordingly, the idea of separating slow and fast equations will be applied for a wide range of complex enzyme inhibitor networks. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the University of Bahrain.
dc.identifier.doi10.1080/25765299.2020.1844369
dc.identifier.endpage449
dc.identifier.issn2576-5299
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85095848246
dc.identifier.scopusqualityQ1
dc.identifier.startpage442
dc.identifier.urihttps://doi.org10.1080/25765299.2020.1844369
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4056
dc.identifier.volume27
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofArab Journal of Basic and Applied Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectenzyme reactions
dc.subjectMathematical modeling
dc.subjectmodel reductions
dc.subjectslow and fast subsystems
dc.titleMathematical modeling for enzyme inhibitors with slow and fast subsystems
dc.typeArticle

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