Evaluation of CBC, Lipid Profile, Oxidative Stress Biomarkers, Total Thiol, Native Thiol, and Disulfide Levels in Dogs Diagnosed with Parvoviral Enteritis Without Clinical Findings

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dc.contributor.authorKurtdede, Efe
dc.contributor.authorBörkü, Mehmet Kazım
dc.contributor.authorGür, Berna
dc.contributor.authorDoğan, Yalçın
dc.contributor.authorSevim, Kadir
dc.contributor.authorGülendağ, Erman
dc.date.accessioned2024-12-24T19:18:17Z
dc.date.available2024-12-24T19:18:17Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, whole blood cell count, metabolic and inflammatory biomarkers, and oxidative stress parameters were evaluated in dogs diagnosed with canine parvoviral enteritis by stool antigen testing performed 24-48 hours before any clinical findings arose. This study aimed to conduct effective evaluations of the status of the disease, the selection of treatment methods, and the prognosis of the disease. Thirty dogs with canine parvoviral enteritis positivity according to stool antigen test results 24-48 hours before the appearance of any clinical signs associated with parvo- viral enteritis (lethargy, vomiting, diarrhea, dehydration) were evaluated together with 10 healthy dogs. In analyses of the dogs with canine parvoviral enteritis, significant decreases were found for white blood cell (P < .001), neutrophil (P < .001), and monocyte (P = .011) counts and significant increases were found for alanine aminotransferase and aspartate aminotransferase (P < .001 for both). Significant increases (P < .001) were also determined for high-density lipoprotein, choles- terol, and triglyceride levels among the studied lipid metabolites and C-reactive protein, malondi- aldehyde, and paraoxonase-1 among inflammatory biomarkers. Significant decreases were found for total thiol (P = .002) and native thiol (P < .001), with which antioxidant levels were evaluated, and a significant increase was found for disulfide (P < .001), with which oxidation was evaluated. It was concluded that early changes in blood samples taken 24-48 hours before the onset of clinical symptoms in dogs with CPV, as reflected by values of CBC and metabolic and inflammatory bio- markers, may provide information about the severity of the disease, the choice of medical treat- ments to be applied, and prognosis.
dc.identifier.doi10.5152/VetSciPract.2022.222745
dc.identifier.endpage102
dc.identifier.issn2822-3608
dc.identifier.issue3
dc.identifier.startpage98
dc.identifier.trdizinid1175926
dc.identifier.urihttps://doi.org/10.5152/VetSciPract.2022.222745
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1175926
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5048
dc.identifier.volume17
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofVeterinary sciences and practices (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectViroloji,Veterinerlik
dc.titleEvaluation of CBC, Lipid Profile, Oxidative Stress Biomarkers, Total Thiol, Native Thiol, and Disulfide Levels in Dogs Diagnosed with Parvoviral Enteritis Without Clinical Findings
dc.typeArticle

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