Potential therapeutic effects of silymarin and silymarin-loaded solid lipidnanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation

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dc.contributor.authorCengiz, Mustafa
dc.contributor.authorAyhancı, Adnan
dc.contributor.authorKutlu, Hatice Mehtap
dc.contributor.authorMusmul, Ahmet
dc.date.accessioned2024-12-24T19:18:42Z
dc.date.available2024-12-24T19:18:42Z
dc.date.issued2016
dc.departmentSiirt Üniversitesi
dc.description.abstractSilymarin (Sm) is widely used in treating diseases that affect organs such as the liver, kidney, and gallbladder thanks to its antioxidative, renoprotective, antihepatotoxic, and anticarcinogenic properties. However, this substance is poorly solved in water and tends to decompose in the intestine, its bioavailability decreasing before it can show real effect. With these limitations in mind, the present study aims to enhance the poor bioavailability of Sm by forming Sm-loaded solid lipid nanoparticles (Sm-SLNs) using the hot homogenization method. A characterization process was undertaken to determine possible impact of Sm on experimental kidney damage. Our biochemical and light microscopic results suggest that the group that received Sm-SLNs for the treatment of D-GalN/TNF-α-induced experimental kidney damage showed significantly more improvement than the group that received commercially available Sm. In conclusion, Sm-loaded SLN may be a useful system for the delivery of poorly water-soluble Sm and may also provide renoprotection.
dc.identifier.endpage814
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue4
dc.identifier.startpage807
dc.identifier.trdizinid214734
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/214734
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5293
dc.identifier.volume40
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Biology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectMühendislik
dc.subjectBiyotıp,Tıbbi Araştırmalar Deneysel,Genel ve Dahili Tıp
dc.titlePotential therapeutic effects of silymarin and silymarin-loaded solid lipidnanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation
dc.typeArticle

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