A comparative study on the therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on D-GaIN/TNF-?-induced liver damage in Balb/c Mice

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dc.contributor.authorCengiz, Mustafa
dc.contributor.authorKutlu, Hatice Mehtap
dc.contributor.authorBurukoglu, Dilek
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2017-05-17T11:45:31Z
dc.date.available2017-05-17T11:45:31Z
dc.date.issued2014-12-25
dc.departmentBelirleneceken_US
dc.description.abstractNanostructure mediated drug delivery is known to have a potential to improve drug bioavailability, apart from fostering release deviation of drug molecules and enabling precision drug targeting. Solid lipid nanoparticles (SLNs) have drawn great deal of the attention of scientists in ?nding a solution to minimize pharmaceutic limitations of the drugs used. Silymarin(Sm)has so far been used for treating diverse liver and gall bladder disorders, such as cirrhosis, hepatitis, and jaundice, and for protecting the liver against poisoning from chemical and environmental toxins on account of its antihepatotoxic and antioxidative properties. The present study aims to develop a novel silymarin-loaded solid lipid nanoparticle (SmloadedSLN) system with enhanced bioavailability and with an ability to provide excellent hepatic protection for poorly water-soluble drugs. Based upon our investigation results with apoptotic markers, PCNA and light microscopic ?ndings, it can be concluded that Sm-loaded SLN signi?cantly reduced D-GaIN/TNF?-induced hepatotoxicity, which suggested improved bioactivity compared to Sm. In conclusion, Sm-loaded SLN could be a useful system for the delivery of poorly water-soluble Sm, apart from providing favourable hepatic protection.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12604/680
dc.language.isoenen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergi Makalesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz#KayıtKontrol#
dc.subjectD-GaIN/TNF-αen_US
dc.subjectHepatotoxicityen_US
dc.subjectSilymarin-loaded solid lipid nanoparticleen_US
dc.subjectHepatoprotectivityen_US
dc.subjectBalb/c miceen_US
dc.titleA comparative study on the therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on D-GaIN/TNF-?-induced liver damage in Balb/c Miceen_US
dc.typeArticleen_US

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