The effect of interferon alpha administration on cytokine levels in sheep

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dc.contributor.authorCoşkun, Devran
dc.contributor.authorİder, Merve
dc.contributor.authorArslan, Mustafa Sedat
dc.contributor.authorCanbar, Rahmi
dc.contributor.authorYazar, Enver
dc.date.accessioned2024-12-24T19:16:03Z
dc.date.available2024-12-24T19:16:03Z
dc.date.issued2020
dc.departmentSiirt Üniversitesi
dc.description.abstractAim: The primary aim of this study was to determine the effect ofparenteral recombinant human interferon (rHuIFN)-?2a administration on serum tumor necrosis factor (TNF)-?, interleukin (IL)-6and IL-10 levels in healthy sheep. In addition, the main physiologicalparameters (rectal temperature, pulse rate, respiratory rate), hemogram and blood gas parameters were determined, as well.Materials and Methods: In this study, 9.000.000 IU rHuIFN-?2awas administered subcutaneously in 10 Merinos sheep. Blood samples were taken before (0 hours) and after at 4, 8, 12, 24, 48, 72, 96and 120 hours. Rectal temperature, pulse and respiratory rate werealso determined at the same sampling times. Sheep-specific TNF-?,IL-6 and IL-10 levels were determined from serum samples by theELISA reader. Hemogram and blood gas parameters were measuredby complete blood cell counter and blood gas analyzer, respectively.Results: After rHuIFN-?2a treatment, TNF-? and IL-10 concentrations reached peak levels (p<0.05) at the 96 hours, whereas the IL-6level did not change in a statistically significant (p>0.05). On the other hand, a temporary increase in rectal temperature and pO2 levels(p<0.05) were determined, while decreased potassium and ionizedcalcium levels (p<0.05) were measured. Statistically significantly(p<0.05) fluctuations were determined in pulse rate, white bloodcell counts, pH, base(ecf) and sodium values.Conclusion: It may be stated that administration of rHuIFN-?2ashowed immunological effects in sheep, as it is generally accepted assafe and can be considered for use in treatment.
dc.identifier.doi10.15312/EurasianJVetSci.2020.315
dc.identifier.endpage330
dc.identifier.issn1309-6958
dc.identifier.issn2146-1953
dc.identifier.issue4
dc.identifier.startpage324
dc.identifier.trdizinid413555
dc.identifier.urihttps://doi.org/10.15312/EurasianJVetSci.2020.315
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/413555
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4203
dc.identifier.volume36
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofEurasian Journal of Veterinary Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectBiyokimya ve Moleküler Biyoloji,İmmünoloji,Veterinerlik
dc.titleThe effect of interferon alpha administration on cytokine levels in sheep
dc.typeArticle

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