Angiogenic factors and evaluation of vascular status in preeclampsia

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dc.authoridAKSIN, SERIF/0000-0002-1301-2508
dc.contributor.authorAksin, Serif
dc.contributor.authorCim, Numan
dc.contributor.authorSahin, Hanim Guler
dc.contributor.authorBalsak, Deniz
dc.date.accessioned2024-12-24T19:32:52Z
dc.date.available2024-12-24T19:32:52Z
dc.date.issued2021
dc.departmentSiirt Üniversitesi
dc.description.abstractAim: The aim of this study was to measure serum levels of the angiogenic factors nitric oxide (NO), soluble endoglin (s Eng), soluble fms-like tyrosine kinase-1 (s Flt-1), placental-derived growth factor (PIGF) and vascular endothelial growth factor (VEGF) and to measure uterine and umbilical arterial blood flow using Doppler ultrasonography to investigate the physiopathology of preeclampsia and endovascular dysfunction by comparing brachial artery dilatation and the thickness of the carotid artery with normal pregnant women. Material and Methods: Forty pregnant women with preeclampsia and 40 healthy pregnant women (control group) were recruited for the study in April 2011 and October 2011 at Van Yuzuncu Yil University. Systolic and diastolic blood pressure, urinary protein in spot urine samples, complete blood counts, aspartate transaminase (AST), alanine aminotransferase (ALT) levels of sEng, sFlt-1, VEGF, PIGF and NO, and APGAR scores at one and five minutes after birth were recorded and compared in all patients. Intima-media thickness of the carotid artery, brachial artery dilatation and umbilical artery Doppler parameters of all pregnant women were assessed and recorded. Results: When compared to the control group, systolic and diastolic blood pressures urinary protein in spot and 24-hour urine collection, levels of AST, ALT and sFlt-1, and uterine artery Doppler parameters were significantly higher, whereas VEGF, platelet count and APGAR scores at one and five minutes after birth were lower in the preeclampsia group (p<0.001). Brachial artery dilatation before obstruction was found to be insignificant in both groups, while post obstructive dilatation was found to be significantly higher in the control group. Discussion: Uterine artery Doppler evaluation, assessment of brachial artery dilatation and measurement of VEGF and sFlt-1 levels seem to be useful in preeclampsia.
dc.identifier.doi10.4328/ACAM.20577
dc.identifier.endpage689
dc.identifier.issn2667-663X
dc.identifier.issue6
dc.identifier.startpage685
dc.identifier.urihttps://doi.org/10.4328/ACAM.20577
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7849
dc.identifier.volume12
dc.identifier.wosWOS:000732052100020
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBayrakol Medical Publisher
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectAngiogenic
dc.subjectPreeclampsia
dc.subjectVascular
dc.subjectBrachial Artery
dc.subjectNitric Oxide
dc.titleAngiogenic factors and evaluation of vascular status in preeclampsia
dc.typeArticle

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