Investigating wound healing and antimicrobial activity of terebinth extract and terebinth extract+oxytetracycline mixture in experimental wounds in mice

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dc.contributor.authorŞındak, Nihat
dc.contributor.authorGülaydın, Ali
dc.contributor.authorGülaydın, Özgül
dc.contributor.authorAkgül, M. Barış
dc.contributor.authorÖzen, Doğukan
dc.date.accessioned2024-12-24T19:18:15Z
dc.date.available2024-12-24T19:18:15Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractObjevtive: The aim of the study is to investigate the wound healing and antibacterial activity of terebinth extract and the mixture of terebinth + 3% oxytetracycline in experimental wounds in mice. Material-Method: The animal material of the study consisted of 18 mice. The animals were divided into 3 groups as control group (group I, n: 6), terebinth group (group II, n: 6), terebinth +oxytetracycline group (group III, n: 6). Wounds with a 1-cm2 diameter were induced on the back of the mice and infected with Staphylococcus aureus ATCC® 25923 reference strain. Treatment protocols of the groups were applied daily. Total aerobic mesophilic bacteria and S. aureus count was performed in the swab samples taken on days 3, 7, and 14 of the healing process. Results: In the study, it was found that wound healing process was completed the earliest in Group III (mean duration of 15.67±0.609 days), which was followed by Group II (18±0.73) and Group I (24.67±0.919), respectively. The healing period was statistically significantly shorter in Group II and Group III than in Group I (p<0.001). In the evaluation of aerobic mesophilic bacteria and S. aureus load, much less live bacteria were found in Group III compared to the other groups. In addition, the bacteria count in group II, in which terebinth extract was used, was less than that of the control group. Conclusion: Consequently, it was concluded that the extract of terebinth plant grown in Siirt region reduced the bacterial load in the wound area and accelerated the healing process.
dc.identifier.doi10.47748/tjvr.1376617
dc.identifier.endpage61
dc.identifier.issn2602-3695
dc.identifier.issue1
dc.identifier.startpage53
dc.identifier.trdizinid1233083
dc.identifier.urihttps://doi.org/10.47748/tjvr.1376617
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1233083
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5023
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Veterinary Research (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectWound healing
dc.subjectmice
dc.subjectAntibacterial
dc.subjectOxytetracycline
dc.subjectTerebinth extract
dc.titleInvestigating wound healing and antimicrobial activity of terebinth extract and terebinth extract+oxytetracycline mixture in experimental wounds in mice
dc.typeArticle

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