Effects of some heavy metals on the activities of carbonic anhydrase enzymes from tumorous and non-tumorous human stomach

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dc.contributor.authorYerlikaya, Emrah
dc.contributor.authorDemirdag, Ramazan
dc.contributor.authorKufrevioglu, Omer Irfan
dc.contributor.authorGundogdu, Cemal
dc.date.accessioned2019-11-18T12:13:22Z
dc.date.available2019-11-18T12:13:22Z
dc.date.issued2015
dc.departmentBelirleneceken_US
dc.description.abstractIn this study, in vitro effects of certain heavy metals on the human carbonic anhydrase enzyme were examined. Inhibitory effects of metal ions (Pb2+, Cu2+, Fe2+, Cr2+, Al3+, Ni2+, Mn2+, Cd2+, Zn2+, and Mg2+) were observed in tumorous and non-tumorous tissue. IC50 values were calculated for metals. The Cu2+, Zn2+, Ni2+, Cd2+ and Mg2+ IC50 values of tumorous tissue were calculated as 0.034 mM, 0.426 mM, 0.597 mM, 0.878 mM and 2.52 mM, respectively. The Cu2+, Zn2+, Ni2+, Cd2+ and Mg2+ IC50 values of non-tumorous tissue were calculated as 0.067 mM, 0.991 mM, 1.065 mM, 1.724 mM and 6.13 mM, respectively. Carbonic anhydrase activity was measured as described by Wilbur and Anderson. Hydratase activity was used to determine IC50 values. In this study, tumorous and non-tumorous human stomach tissues were selected due to the fact that among the diseases, stomach cancer has one of the highest mortality rates. Stomach cancer, a type of cancer affecting the digestive system, is a fatal disease in living systems. The effects of metals on the CA enzyme were investigated due to the extremely important role that CA enzymes play in living beings.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12604/1625
dc.language.isoenen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergi Makalesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz#KayıtKontrol#
dc.subjectCarbonic anhydrase, heavy metals,tumorous, inhibitionen_US
dc.titleEffects of some heavy metals on the activities of carbonic anhydrase enzymes from tumorous and non-tumorous human stomachen_US
dc.typeArticleen_US

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