Investigation of Protecting Effect of Boric Acid against Mercury II Chloride Toxicity in Rat Brain Tissue

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dc.contributor.authorAkkoyun, H. Turan
dc.contributor.authorBengü, Aydın Şükrü
dc.contributor.authorUlucan, Aykut
dc.contributor.authorAkkoyun, Mahire Bayramoğlu
dc.contributor.authorİzgi, Mehmet Sait
dc.contributor.authorŞahin, Ömer
dc.contributor.authorEkin, Suat
dc.date.accessioned2024-12-24T19:18:10Z
dc.date.available2024-12-24T19:18:10Z
dc.date.issued2020
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, the protective effects of boric acid (BA) in the prevention of brain damagecaused by mercury II chloride ( HgCl2) in rats were investigated. In the experiment, 24 adult andWistar albino male rats weighing roundly 200-300 g were used. Group I (Control, n=8): Isotonicsaline (i.p), Group II (HgCl2,n=8):(0.01g/kg)(oral), Group III (HgCl2 + (BA) (n:8): HgCl2(0.01g/kg)+ BA (3.25mg/kg/day i.p.) group were administered. The rats in all groups were sacrificed at theend of the 10th day and their brain tissues were taken. Biochemical parameters including theenzyme activities of SOD, CAT and GSH-Px were measured. The enzyme activity of SOD wasreduced in HgCl2 treated group in comparison to the control group (p<0.001). Activity of theenzyme was increased after BA administration (p?0.001). CAT enzyme activity decreased in HgCl2and HgCl2+BA administered groups with control (p?0.001). An increase in enzyme activity in BAgroup with HgCl2 administered group was observed. GSH-Px enzyme activity decreased in HgCl2(p?0.001) and HgCl2+BA (p?0.05) groups with control. However, an increase was found in BAadministered group with HgCl2 administered group (p?0.001). It is thought that antioxidant enzymeactivities such as SOD, CAT and GSH-Px are significantly changed and BA may have a protectiveeffect in the histopathological examination of brain tissue.
dc.identifier.doi10.46810/tdfd.819741
dc.identifier.endpage133
dc.identifier.issn2149-6366
dc.identifier.issue2
dc.identifier.startpage127
dc.identifier.trdizinid448306
dc.identifier.urihttps://doi.org/10.46810/tdfd.819741
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/448306
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4989
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTürk Doğa ve Fen Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectTıbbi Araştırmalar Deneysel,Nörolojik Bilimler,Biyokimya ve Moleküler Biyoloji
dc.titleInvestigation of Protecting Effect of Boric Acid against Mercury II Chloride Toxicity in Rat Brain Tissue
dc.typeArticle

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