Effect of carbon tetrachloride (CCl4) and ellagic acid on rat erythrocyte G6PD, 6PGD, GR, GST and TrxR enzyme activities

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dc.contributor.authorAkkoyun, Mahire Bayramoglu
dc.contributor.authorTuran Akkoyun, H.
dc.date.accessioned2024-12-24T19:09:58Z
dc.date.available2024-12-24T19:09:58Z
dc.date.issued2019
dc.departmentSiirt Üniversitesi
dc.description.abstractIn presented study, in vivo effects of the important polyphenol ellagic acid and CCl4 compound known for its toxic effects on metabolic activity levels of some rat erythrocyte enzymes such as G6PD (glucose 6-phosphate dehydrogenase), 6PGD (6-phosphogluconate dehydrogenase), GR (Glutathione reductase), TrxR (Thioredoxin reductase) and GST (Glutathione S-transferase) were investigated. G6PD enzyme activity meaning rised in CCl4 group and ellagic acid+CCl4 group compared to the control group (p<0.001). 6PGD enzyme activity decreased in CCl4 applyed group compared to control group (p<0.05). The enzyme activity level increased in ellagic acid (p<0.05) and CCl4+ellagic acid (p<0.01) applied groups. An increase was observed in ellagic acid (p<0.001) and CCl4+ellagic acid (p<0.001) applied groups compared to CCl4 administered group. GST enzyme activity reduced in CCl4 applied group compared to control group (p<0.01). GR enzyme activity decreased significantly in CCl4 and ellagic acid groups compared to control group (p<0.05 and p<0.01). TrxR enzyme activity decreased in CCl4 group and ellagic acid administered group compared to control group (pO.OOl). A decrease in CCl4+ellagic acid group compared to control was also observed (p<0,001). © by PSP.
dc.identifier.endpage6785
dc.identifier.issn1018-4619
dc.identifier.issue9
dc.identifier.scopus2-s2.0-85071662829
dc.identifier.scopusqualityN/A
dc.identifier.startpage6779
dc.identifier.urihttps://hdl.handle.net/20.500.12604/3867
dc.identifier.volume28
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherParlar Scientific Publications
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectCarbon tetra chloride
dc.subjectEllagic acid
dc.subjectMetabolic enzyme
dc.titleEffect of carbon tetrachloride (CCl4) and ellagic acid on rat erythrocyte G6PD, 6PGD, GR, GST and TrxR enzyme activities
dc.typeArticle

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