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    Boron Prevents Oral Acrylamide Damage in Bone Marrow and Hematologic Parameters of Wistar Rats
    (Springer Science and Business Media LLC, 2025-04-07) Faysal Selimoğlu; Mustafa Cengiz; Canan Vejselova Sezer; Adnan Ayhanci; Fatma Gür; Özge Yıldırım; Bahri Gür; Ahmet Musmul
    The purpose of this study is to measure the effects of acrylamide (AA) on bone marrow and blood and the protective efficacy of boric acid (B) in rats. The animals were divided into five groups: control, B, low-dose B + AA, and high-dose B + AA. After the 15 th day of the experiment, their blood and bone marrow were harvested to be kept for hematological analyses. While white blood cells (WBC) increased following the administration of AA, bodyweight, red blood cells, platelets, hemoglobin, hematocrit, and bone marrow nucleated cell counts significantly decreased in number. Conversely, bodyweight and all these hematological parameters significantly increased apart from WBC in the B + AA groups AA when compared to the control. However, high-dose B was more effective than low-dose B in preventing AA-induced bone marrow and hematological damage. The present study suggests that B treatment could help protect bone marrow and hematological parameters against AA-induced toxicity.
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    Different essential oils can inhibit Candida albicans biofilm formation on acrylic resin by suppressing aspartic proteinase: In vitro and in silico approaches
    (Springer Science and Business Media LLC, 2025-01-28) Nurdan Polat Sağsöz; Leyla Güven; Bahri Gür; Canan Vejselova Sezer; Mustafa Cengiz; Figen Orhan; Özlem Barış
    Introduction: Cymbopogon martini, Syzygium aromaticum, and Cupressus sempervirens are used for antimicrobial purposes in the worldwide. Both their extracts and essential oil contents are rich in active ingredients. Objective: The aim of this study was to investigate the inhibitory effect of Cymbopogon martini essential oil (CMEO), Syzygium aromaticum essential oil (SAEO) and Cupressus sempervirens essential oil (CSEO) on Candida albicans biofilm formation on heat-polymerized polymethyl methacrylate (PMMA) samples in vitro and in silico. Materials and methods: Essential oil contents with anticandidal potential were determined by Gas Chromatography-Mass Spectrometry. Following C. albicans adhesion, PMMA samples were treated independently with Corega® and each essential oil. The anticandidal activity of the essential oils was determined by spectrophotometric absorbance measurement at 600 nm, taking into account the cultures of each sample. The cytotoxicity evaluation of essential oils was performed by MTT Colorimetric assay. The software package AutoDockTools (1.5.6) was used for the in silico studies. The effect of essential oil content on the inhibition of Secreted aspartic proteinase (SAP2) was evaluated considering the Ligand@SAP2 complex formation. Results: 2% of CMEO and 5% of SAEO exhibited higher anticandidal activity than Corega® (p < 0.05), whereas Corega® had higher anticandidal activity than 2% and 5% of CSEO (p < 0.05). The cytotoxicity of essential oils on NIH/3T3 cells after 24 h was found to be 2.41 for CSEO, 2.84 for CMEO, and 2.85 µg/mL for SAEO. The results of the in silico study showed that citronellol from CMEO, chavibetol (m-eugenol) from SAEO and β-pinene from CSEO each had the highest effect on the inhibition of SAP2. The highest binding affinity value was found for citronellol at -5.3 kcal/mol. Conclusions: The biofilm formation of C. albicans onto acrylic resin was inhibited by CMEO, SAEO and CSEO at a concentration of 2% through in vitro assay. The most effective inhibition was determined to be due to citronellol in CMEO through in silico analysis.
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    Eco-friendly biosynthesized silver, copper, and nickel nanoparticles mediated Rheum ribes: Assessment of their cytotoxicity and antimicrobial activity
    (Elsevier BV, 2025-02) Bahri Gür; Mustafa Cengiz; Canan Vejselova Sezer; Orhan Baytar; Ömer Şahin; Adnan Ayhanci; Hatice Mehtap Kutlu
    Background: The green synthesis of metallic nanoparticles has recently become a research area of increasing interest due to their potential applications in nanomedicine. Aim of study: This study aimed to investigate, for the first time, the anticancer properties of silver nanoparticles (Ag-NPs), copper oxide nanoparticles (CuO-NPs), and nickel oxide nanoparticles (NiO-NPs) on A549 and Beas-2B cell lines, as well as their antibacterial efficacy against Escherichia coli and Staphylococcus aureus strains, synthesized through a green synthesis approach utilizing Rheum ribes plant extract. Methodology: The current study introduces a sustainable and environmentally friendly method for the biosynthesis of Ag-NPs, CuO-NPs, and NiO-NPs utilizing the aqueous extract of Rhubarb (Rheum ribes). The spectroscopic and morphological properties of the Ag-NPs, CuO-NPs, and NiO-NPs obtained from the Rheum ribes extract were confirmed using different analytical techniques. Results: The Ag-NPs, CuO-NPs, and NiO-NPs exhibited different morphology with a size of about 7.90, 12.0, and 12.63 nm, respectively, and were free of impurities and highly stable particles. In addition, the NPs were further investigated for their anticancer and antibacterial properties. The anticancer effects of the NPs were assessed using the MTT assay and confocal microscopy in non-small cell lung cancer (A549) and healthy lung (Beas-2B) cells. The study results demonstrated that Ag-NPs, CuO-NPs, and NiO-NPs had cytotoxic effects on A549 cells that were concentration-based, having IC50 values of 4.16, 21.28, and 37.68 μg/mL, in that order. Additionally, it was observed that the above-mentioned NPs exhibited strong activity against bacteria. Conclusions: The nanoparticles derived from Rheum ribes extract appear to hold great potential as a class of nano-biomaterials intended for usage in biological fields.