Synthesis of ionic liquid‑based Ru(II)–phosphinite complexes and evaluation of their antioxidant, antibacterial, DNA‑binding, and DNA cleavage activities

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dc.authoridhttps://orcid.org/0000-0002-5505-2700en_US
dc.contributor.authorMeriç, Nermin
dc.contributor.authorKayan, Cezmi
dc.contributor.authorRafikova, Khadichakhan
dc.contributor.authorZazybin, Alexey
dc.contributor.authorOkumuş, Veysi
dc.contributor.authorAydemir, Murat
dc.contributor.authorDurap, Feyyaz
dc.date.accessioned2019-12-23T07:47:23Z
dc.date.available2019-12-23T07:47:23Z
dc.date.issued2019en_US
dc.departmentFen - Edebiyat Fakültesien_US
dc.description.abstractTwo Ru(II) complexes were synthesized by reaction of phosphinite-functionalized imidazolium salts [(Ph2PO)C7H11N2Cl] Cl (1) and [(Cy2PO)C7H11N2Cl]Cl (2) with 1/2 equivalent of [Ru(η6-p-cymene)(μ-Cl)Cl]2 in anhydrous CH2Cl2 and under argon atmosphere. The complexes were then isolated as analytically pure substances and characterized using multinuclear NMR and infrared spectroscopies and elemental analysis. The Ru(II) compounds were used to study their biological assay. For this purpose, radical scavenging, reducing power, antibacterial activity, DNA binding, and DNA cleavage activity were fully studied. The maximum 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH) scavenging (78.9%) and reducing power were obtained from compound 4 at the concentration of 200 μg/ml. The compounds were also tested against three Gram-positive and three Gram-negative bacteria, and they were found to be more effective against Gram-positive bacteria. In addition, both compounds showed excellent DNA binding and DNA cleavage activity.en_US
dc.description.provenanceSubmitted by Veysi OKUMUŞ (veysiokumus@siirt.edu.tr) on 2019-12-22T19:51:09Z No. of bitstreams: 1 A34.pdf: 1047378 bytes, checksum: a597c9cb2fc1175ca5406542051067cd (MD5)en
dc.description.provenanceApproved for entry into archive by Esra Diriarın (esradiriarin@siirt.edu.tr) on 2019-12-23T07:47:23Z (GMT) No. of bitstreams: 1 A34.pdf: 1047378 bytes, checksum: a597c9cb2fc1175ca5406542051067cd (MD5)en
dc.description.provenanceMade available in DSpace on 2019-12-23T07:47:23Z (GMT). No. of bitstreams: 1 A34.pdf: 1047378 bytes, checksum: a597c9cb2fc1175ca5406542051067cd (MD5) Previous issue date: 2019en
dc.identifier.citationMeriç, N. Kayan, C. Khadichakhan, R. Alexey, Z. Veysi, O. & Murat, A.(2019). Synthesis of ionic liquid‑based Ru(II)–phosphinite complexes and evaluation of their antioxidant, antibacterial, DNA‑binding and DNA cleavage activities : Chemical Papers.en_US
dc.identifier.endpage1208en_US
dc.identifier.issue5en_US
dc.identifier.startpage1199en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12604/2355
dc.identifier.volume73en_US
dc.institutionauthorOkumuş, Veysi
dc.language.isoenen_US
dc.publisherChemical Papersen_US
dc.relation.ispartofChemical Papers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz#KayıtKontrol#
dc.subjectIonic liquiden_US
dc.subjectPhosphiniteen_US
dc.subjectRutheniumen_US
dc.subjectAntibacterialen_US
dc.subjectDNA bindingen_US
dc.subjectDNA cleavageen_US
dc.titleSynthesis of ionic liquid‑based Ru(II)–phosphinite complexes and evaluation of their antioxidant, antibacterial, DNA‑binding, and DNA cleavage activitiesen_US
dc.typeArticleen_US

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