DNA Cleavage Properties and Synthesis of Metallophthalocyanines with 5-Methyl-[1, 2, 4] triazolo [1, 5-a] pyrimidin-7-oxy Substituents. Inorganic and Nano-Metal Chemistry

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dc.contributor.authorAğırtaş, M.S., Ondes, M.Y., Ozdemir, S., Okumus, V.
dc.date.accessioned2017-05-02T17:41:07Z
dc.date.available2017-05-02T17:41:07Z
dc.date.issued2017-01-23
dc.departmentBelirleneceken_US
dc.description.abstractThe aim of the present study is to perform synthesis of novel metallophthalocyanines (pcs) with high solubility. The synthesis and characterization of 5-methyl-[1, 2, 4] triazolo [1, 5-a] pyrimidin-7-yloxy-substituted zinc, magnesium, and cobalt pcs are reported. These compounds have been characterized using electronic absorption, nuclear magnetic resonance spectroscopy, infrared, elemental analysis and mass spectra. The aggregation investigations carried out in different concentrations indicate that 5-methyl-[1, 2, 4] triazolo [1, 5-a] pyrimidin-7-yloxy-substituted pc complexes do not have any aggregation behavior for the concentration range of 1 × 10-5-1 × 10-6 M in THF. DPPH radical scavenging activity, metal chelating activity, and reducing power of the compounds were evaluated. The DNA gel electrophoresis studies revealed that new phthalonitrile and its metallophthalocyanine compounds cleavaged plasmid DNA (pBR322). Additionally, the ground-state geometries of the complexes were optimized using density functional theory methods at B3LYP/6-31G (d, p) level in order to obtain information about the 3D geometries and electronic structure.en_US
dc.description.provenanceSubmitted by Veysi OKUMUŞ (veysiok@hotmail.com) on 2017-05-02T17:41:07Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2017-05-02T17:41:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-23en
dc.identifier.urihttps://hdl.handle.net/20.500.12604/427
dc.language.isoenen_US
dc.publisherInorganic and Nano-Metal Chemistryen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergi Makalesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz#KayıtKontrol#
dc.subjectPhthalocyanine, synthesis, electronic structure, aggregation, DNA cleavageen_US
dc.titleDNA Cleavage Properties and Synthesis of Metallophthalocyanines with 5-Methyl-[1, 2, 4] triazolo [1, 5-a] pyrimidin-7-oxy Substituents. Inorganic and Nano-Metal Chemistryen_US
dc.typeArticleen_US

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