Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial and DNA binding activities
| dc.contributor.author | Gümüş, Ayşegül | |
| dc.contributor.author | Okumuş, Veysi | |
| dc.date.accessioned | 2019-11-28T16:00:12Z | |
| dc.date.available | 2019-11-28T16:00:12Z | |
| dc.date.issued | 2018 | en_US |
| dc.department | Fen - Edebiyat Fakültesi | en_US |
| dc.description.abstract | One-pot synthesis of novel quinoline- and quinolone-substituted 1,2,3-triazoles has been performed from the key intermediates, quinoline- and quinolone-substituted propargyl derivatives 1–3 (48%–88% yields). The antioxidant properties of the newly synthesized compounds, 1a–1c, 2a–2c, and 3a–3c, were evaluated by monitoring DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging abilities, metal chelating effects, and reducing power. The scavenging effects of compounds on the free radical decreased in the order of 3b > 3a > 1b and were found to be 36.3%, 34.9%, and 27.6% at the concentration of 500 g/mL, respectively. All of the compounds showed low chelating capacity. Furthermore, the antibacterial activity was studied against gram-positive and gram-negative bacteria and the DNA binding ability of the compounds was evaluated with calf thymus DNA using agarose gel electrophoresis. | en_US |
| dc.description.provenance | Submitted by Veysi OKUMUŞ (veysiokumus@siirt.edu.tr) on 2019-11-28T16:00:12Z No. of bitstreams: 1 A32.pdf: 557403 bytes, checksum: 2671ea1d0a77f5c5f5ee44ae3924e2e6 (MD5) | en |
| dc.description.provenance | Made available in DSpace on 2019-11-28T16:00:12Z (GMT). No. of bitstreams: 1 A32.pdf: 557403 bytes, checksum: 2671ea1d0a77f5c5f5ee44ae3924e2e6 (MD5) Previous issue date: 2018 | en |
| dc.identifier.endpage | 1369 | en_US |
| dc.identifier.issue | 42 | en_US |
| dc.identifier.startpage | 1358 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12604/2006 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Turkish Journal of Chemistry | |
| dc.relation.publicationcategory | Makale - Uluslararası - Editör Denetimli Dergi | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.snmz | #KayıtKontrol# | |
| dc.subject | Quinoline, quinolone, triazole, antioxidant, antibacterial | en_US |
| dc.title | Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial and DNA binding activities | en_US |
| dc.type | Article | en_US |
