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Öğe Interpretable Artificial Intelligence for Analysing Changes in Gases in the Uterine Environment of Cows According to Physiological Structures in the Ovary(Wiley, 2025-02-19) Ali Risvanli; Burak Tanyeri; Güngör Yildirim; Yetkin Tatar; Mehmet Gedikpinar; Hakan Kalender; Tarik Safak; Burak Yuksel; Burcu Karagulle; Oznur Yilmaz Koç; Cebrail Barut; Mehmet Akif KilincThe objective of the present study was to examine the relationship between the gases in a cow's uterine environment and its ovarian physiological structures using the sunflower optimisation algorithm (SFOA) deployed in a device called Metrisör, developed by our project team. A total of 500 uteruses obtained from slaughtered cows served as the experimental sample. Gas measurements were taken from 489 uteruses with no clinical metritis or microbiological growth. Additionally, the diameters of the corpus luteum and follicles in the ovaries were measured using callipers. These results were then analysed based on the presence or absence of a corpus luteum (CL) and follicles larger or smaller than 1.5 cm. According to uterine gas fluctuations, the presence and absence of CL could be detected at rates of 80.60% and 79.60%, respectively. Also, based on uterine gas changes, the presence of ovarian follicles larger than 1.5 cm was determined 82% of the time, and the presence of follicles smaller than 1.5 cm was determined 80% of the time. In conclusion, it was found that different stages of a cow's sexual cycle might involve changes in uterine gases. Thus, the data from this study may enable the development of a new estrus detection method for cows.Öğe Investigation of the effects of propofol and sevoflurane anesthesia on oxidant-antioxidant status and biochemical parameters in Turkish hair goats(American Veterinary Medical Association (AVMA), 2025-02-17) Ali Gülaydın; Kıvanç İrak; Nihat Şındak; Mustafa Barış Akgül; Özgür Yaşar Çelik; Onur Yıldırım; Maruf Yılmaz; Erman GülendağObjective: To investigate the effects of propofol and sevoflurane anesthesia on the oxidant-antioxidant status and biochemical parameters in Turkish hair goats. Methods: The study was conducted from February 15 through March 15, 2024. Seven clinically healthy female Turkish hair goats aged 1 to 2 years with an average live weight of 29.95 (26.1 to 33.8) kg were included. A bolus of propofol (6 mg/kg) was injected IV. The goats were placed in the sternoabdominal position and administered 1% to 3% sevoflurane with 100% oxygen for 2 hours with the help of a vaporizer. Blood samples were collected before and after the administration of propofol and at the 15th, 30th, 60th, and 120th minutes after the start of sevoflurane administration in nonanticoagulated tubes. The oxidant-antioxidant status (serum total antioxidant status, total oxidant status, paraoxonase activity, and arylesterase activity) and biochemical parameters (levels of glucose, AST, GGT, ALT, ALP, LDH, creatine kinase, amylase, lipase, creatinine, urea, uric acid, high-density lipoprotein, low-density lipoprotein, total protein, albumin, total bilirubin, direct bilirubin, magnesium, chlorine, calcium, iron, sodium, phosphorus, and potassium) were evaluated. The heart rate, respiratory rate, and body temperature of the goats were measured using a bedside monitor. Results: Arylesterase activity increased with sevoflurane administration. Changes were observed in heart rate and body temperature as well as in the levels of glucose, creatine kinase, urea, total bilirubin, and potassium at different time intervals of propofol-sevoflurane administration. Conclusions: Propofol-sevoflurane anesthesia has no adverse effects on oxidant-antioxidant status in Turkish hair goats. Clinical relevance: The evaluation of heart rate and body temperature, as well as glucose, creatine kinase, urea, total bilirubin, and potassium levels, must be considered in propofol-sevoflurane anesthesia protocol.Öğe Effects of propolis supplementation during cryopreservation of ram semen.(2024) Güngör, I H; Özer Kaya, Ş; Dayan Cinkara, S; Çakır Cihangiroğlu, A; Kaya, E; Acısu, T C; Erdem Erişir, F; Yılmaz, Ö; Yılmaz, S; Gür, S; Sönmez, M; Türk, GBackground: Cryopreservation of ram semen is a very challenging process. Loss of motility during freezing does not allow artificial insemination of rams. Aims: This study aimed to determine whether the inclusion of liquid propolis extract in semen diluents affects the cryopreservation efficiency of ram semen. Methods: Six Akkaraman breed rams were considered for semen study. Semens were combined with Tris+egg yolk extender containing and without (control) propolis at different concentrations (0.25%, 0.50%, 1%, 2%, and 4%). Semen was frozen using routine ram semen freezing procedures. After thawing, motility and kinematic parameters were analyzed by computer assisted semen analysis (CASA), and viability, acrosomal damage level and mitochondrial membrane potential were analyzed by flow-cytometer in all groups. Additionally, fatty acid levels in total semen were analyzed using gas chromatography (GC), and vitamin and cholesterol levels were analyzed using high-performance liquid chromatography (HPLC). In addition, oxidative stress, HOS test, and morphological analyzes were performed after freezing and thawing. Results: The 0.5% propolis group showed a significant increase in total and rapid motility, LIN, membrane integrity, and antioxidant levels compared to the control, and a significant decrease in malondialdehyde (MDA) and low mitochondrial membrane potential (LMMP) levels. Compared to the control, the group containing 4% propolis damaged spermatozoa and caused a significant decrease in total, progressive and rapid motility and high mitochondrial membrane potential (HMMP), Glutathione S-transferase (GST), and catalase (CAT) levels. Conclusion: We showed that adding 0.5% propolis to semen extenders to increase the freezability level of ram semen increases the survival of spermatozoa after freeze-thaw and ensures the success of freezing.Öğe In vitro effect of platelet-rich plasma (PRP) on morpho-functional characteristics, oxidative stress, apoptosis and CatSper-1 ion channel in short-term stored (5 °C) ram semen(Elsevier BV, 2025-03) Gaffari Türk; İbrahim Halil Güngör; Gözde Arkalı; Aslıhan Çakır Cihangiroğlu; Nida Badıllı; Tutku Can Acisu; Serap Dayan Cinkara; Şuheda Yüksel; Şeyma Özer Kaya; Mustafa Sönmez; Seyfettin Gür; Abdurrauf YüceThe objective of this study was to examine the impact of platelet-rich plasma (PRP) on the morpho-functional characteristics, oxidative stress, apoptosis and CatSper-1 ion channel in short-term stored ram semen at 5 °C. The study was conducted in six independent replicates on pooled semen samples collected by artificial vagina from six sexually active Akkaraman rams. The pooled semen samples were diluted to a concentration of 400 million spermatozoa per milliliter with a tris-based diluent including 6 PRP concentration (1, 2, 4, 8, 10, 20 %) and no PRP (control) at 38 °C. Following the reduction of the temperature to 5 °C, diluted semen samples were stored for a period of 96 hours. Motility (total, progressive, rapid, medium, low), kinematic (VCL, VSL, VAP, LIN, STR, WOB, ALH, BCF), morphological (plasma membrane integrity, abnormality), flow-cytometric (mitochondrial activity, acrosomal damage, viability, apoptosis), oxidative stress (MDA, GSH, GSH-Px, CAT), and CatSper-1 analyses were performed at both hours zero (initial measurement) and 96. In all groups, a time-dependent deterioration was observed in nearly all parameters at 96 h in comparison to the 0 h. Compared to the control, live spermatozoon rates (8 % and 10 %), GSH-Px (4 %, 8 % and 10 %) and CAT (4 % and 8 %) activities, and CatSper-1 levels at 96 h were higher, while the apoptotic spermatozoon rates (8 % and 10 %) and MDA levels (4 %, 8 % and 10 %) were lower in semen samples containing PRP. However, in semen samples containing 20 % PRP, the apoptotic spermatozoon rates and MDA levels at 96 h were higher, while GSH-Px activity and CatSper-1 levels were lower than in the control. As a result, it was concluded that the addition of 4–10 % PRP to the diluent containing tris+egg yolk has an effective role in preventing oxidative, apoptotic and ion channel (CatSper-1) damages in ram spermatozoa stored for a short time at 5 °C, while the concentration of 20 % is harmful.Öğe Evaluation of the Accuracy and Performance of Two Commercial Pregnancy‐Associated Glycoprotein Tests for Early Pregnancy Detection in Cows(Wiley, 2025-01-28) Tarik Safak; Kenan Çağrı Tümer; Yağmur İpek Alp; Taha Yasin Özen; Oznur Yilmaz‐KocThe aim of this study was to determine and compare the diagnostic accuracies of two commercial pregnancy-associated glycoprotein tests, Alertys OnFarm Pregnancy Test (AOPT) and Alertys Milk Pregnancy Test (AMPT), for early pregnancy diagnosis in dairy cattle. Holstein cows (n = 124) were used in the study. Whole blood samples were collected from the jugular vein 28 days after fixed-time artificial insemination (FTAI). In addition, teats of these cows were swabbed and milk samples were collected into sterile Falcon tubes. AOPT was performed on the farm within 2 h after whole blood collection. Milk samples for AMPT analysis were taken to the laboratory and analysed within 2 h. Transrectal ultrasonography was performed on the 32nd day after FTAI as a reference test. Comparative evaluation was made according to the AOPT and AMPT results, 28 days after FTAI. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) for the AOPT were 92.4%, 80.0%, 87.9%, 89.0% and 85.7% and for AMPT were 97.5%, 82.2%, 91.9%, 90.6% and 94.9% respectively. Cohen's kappa statistic showed a 91.9% agreement (kappa = 0.820, p < 0.001) between the reference test and AMPT, and an 87.9% agreement (kappa = 0.735, p < 0.001) between the reference test and AOPT. AOPT and AMPT offers a reliable, non-invasive (in milk) and practical approach to pregnancy diagnosis in cows. These methods enable early pregnancy detection and can be easily integrated into farm routines, enhancing reproductive management and overall herd productivity.Öğe High-Sensitive Cardiac Troponin I and Th1/Th2 Polarization in Queens With Pyometra.(Veterinary Medicine and Science, 2025-01) Safak, Tarik; Saat, Nevzat; Yilmaz-Koc, Oznur; Turanli, Mert; Ayalp-Erkan, Aslıhan; Risvanli, AliTo determine T helper (Th)1 and Th2 cytokine polarization, as well as high-sensitive cardiac troponin I (hs-cTnI) levels, in cats with pyometra.Öğe The Effect of Cholesterol-Loaded Cyclodextrin and Resveratrol Compounds on Post-Thawing Quality of Ram Semen.(Wiley, 2025-01) Ahmet, Eser; Ramazan, Arıcı; Selin, Yağcıoğlu; İzem, Sandal Asiye; Nur, Ersoy; Kamber, Demir; Mithat, Evecen; Kemal, AkRam sperm are more vulnerable to freezing than those of most other farm animals. During sperm freezing, the cell membrane loses some of its cholesterol, which regulates signalling mechanisms and prevents premature capacitation. Resveratrol (RES) increases the fluidity of the cell membrane, which becomes peroxidized during freezing and reduces free radicals. In this study, the effectiveness of RES, cholesterol-loaded cyclodextrin (CLC) and their combinations in ram sperm cryopreservation were investigated. The collected semen was divided into two equal volumes: One was diluted with tris-citric acid-glucose medium (TCG) containing CLC, whereas the other was diluted with a CLC-free TCG solution. After examining motility, both groups were further divided into two equal volumes, forming the following working groups: control (no RES, no CLC); RES (20 µg/mL); CLC (2 mg CLC/120 × 10 sperm); and RES + CLC (RES 20 µg/mL + 2 mg CLC/120 × 10 sperm). These groups were diluted with media containing their respective additives. Post-thawing, the samples were analysed for motility, acrosome and membrane integrity, membrane functionality, mitochondrial activity, capacitation status, oxidative stress and DNA integrity. CLC preserved sperm total motility, acrosome and plasma membrane integrity and decreased the rate of early capacitation (p < 0.05). RES had no significant effect on sperm quality before freezing and post-thawing (p > 0.05). However, RES + CLC increased mitochondrial activity post-thawing (p < 0.05). In conclusion, CLC minimized sperm membrane damage caused by cryopreservation in ram sperm. RES alone was ineffective, and the combination of RES and CLC did not yield a positive synergistic effect on ram spermatological parameters.Öğe The Relationship of Th/Th Cytokine Polarization at Parturition in Cows and SOCS3 Level With Some Postpartum Diseases.(2025-01) Yilmaz Koc, Oznur; Risvanli, AliTh/Th polarisation and suppressor of cytokine signalling-3 (SOCS3) are important indicators of the humoral and cellular immune system activity in cows. The aim of this study was to determine the correlation of postpartum diseases with the levels of Th/Th polarisation and SOCS3 at the time of parturition. The study examined 180 cows (90 with normal parturition [NP] and 90 with dystocia [D]). Blood samples were taken from the cows once at the time of calving. Two subgroups were created among cows with NP: those without the postpartum disease (NP [-], n = 45) and those with postpartum disease (NP [+], n = 45). Likewise, two subgroups were created among D cows: those without postpartum disease (D [-], n = 45) and those with postpartum disease (D [+], n = 45). Cytokine analyses were performed using species-specific commercial ELISA kits. In the NP (-) group, it was found that Th/Th cytokine polarisation was in the Th direction due to the increase in the concentration of IFN-γ, TNF-α and IL-2 in four subgroups grouping with different types of parturition and diseases. It was concluded that it would be appropriate to strengthen cellular immunity. In cases of postpartum diseases, Th/Th polarisation shifted towards Th due to the increase in IL-4 and IL-5 concentrations in cows that performed NP and developed mastitis in the postpartum period. These results suggest that it would be beneficial to support the Th aspect (i.e. humoral immunity) in cows that have undergone NP and develop mastitis in the postpartum period.Öğe Investigation of the presence of Chlamydia spp., Mycoplasma spp. and Moraxella ovis in infectious keratoconjunctivitis cases in sheep and goats in Siirt province and evaluation of clinical findings(Polish Academy of Sciences Chancellery, 2024-06-12) A. Gulaydin; O. Gulaydin; M.B. Akgul; N. Sindak; O. YildirimInfectious keratoconjunctivitis is an infectious disease that negatively affects animal welfare causing systemic or local clinical signs in small ruminants and causes significant economic losses in herds. It is important to determine the etiologic agent causing the infection in the development of the protection and control strategies against the disease. The aim of this study was to determine the presence of infectious keratoconjunctivitis cases in small ruminants raised in Siirt province in Türkiye. Infectious keratoconjunctivitis was graded according to the symptoms determined by clinical examination. The presence of Chlamydia spp., Mycoplasma spp. and Moraxella ovis was investigated by PCR in swab samples obtained from the animals with keratoconjunctivitis. Infectious keratoconjunctivitis was detected in 263 (19.86%) of 1324 animals examined in the study. Of the animals with infectious keratoconjunctivitis, 163 (61.97%) were sheep and 100 (38.02%) were goats. The detection rate of infectious keratoconjunctivitis was higher in sheep than goats. In 56 (21.29%), 109 (41.44%), 67 (25.47%), and 31 (11.78%) of the cases, findings of stage 1, 2, 3, and 4 infectious keratoconjunctivitis were detected, respectively. Of the eye swab samples taken from 263 animals with infectious keratoconjunctivitis, 5 (1.90%) were positive for Mycoplasma spp. and 6 (2.28%) were positive for M. ovis. It was determined that the distribution of the bacterial agents varied according to the stage of infectious keratoconjunctivitis. No statistically significant correlation was found in the distribution of bacterial agents among identified samples according to species, sex, age, and infectious keratoconjunctivitis stage of the animals. It was thought that the data obtained in the study would contribute to the studies for protection and control by determining the incidence and aetiology of infectious keratoconjunctivitis cases observed in small ruminants. © 2024 The Authors. This is an open access article under the CC BY-NC-ND 4.0 license (https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en), which allows re-users to copy and distribute the material in any medium or format in unadapted form and for noncommercial purposes, and only so long as attribution is given to the creator.Öğe Evaluation of β-hydroxybutyrate, calcium, and non-esterified fatty acids at day one postpartum in predicting the risk of diseases in dairy cows(University of Veterinary Sciences Brno, 2024) Tarik Safak; Efe Durukan; Oznur Yilmaz-Koc; Ali Risvanli; Berrak Isik Soyturk; Metin BayraktarIn this study, the usability of calving type, non-esterified fatty acids (NEFA), beta-hydroxybutyrate (BHB), and calcium (Ca) concentrations in predicting postpartum diseases was examined. For this purpose, 120 Holstein cows were used in the study. These cows were divided into two subgroups according to the calving type: unassisted parturition (eutocic, n = 58) and assisted parturition (dystocia, n = 62). Cows were followed for 15 days postpartum. Diseases of retained foetal membranes (RFM), metritis, and clinical mastitis that developed in the postpartum period were recorded. Then, NEFA, BHB, and Ca concentrations were measured in blood samples collected at parturition from cows with RFM (n = 19), metritis (n = 34), clinical mastitis (n = 20) and cows that did not develop the disease (n = 47). Our results show the decreased Ca concentration to be positively associated with the risk of mastitis (P < 0.001, odds ratio [OR] 4.599), metritis (P = 0.008, OR 4.286), and RFM (P < 0.001, OR 5.016); and increased BHB concentration to be positively associated with the risk of metritis (P = 0.002, OR 4.069) and RFM (P < 0.001, OR 9.498). The results of the study indicated that low Ca and high BHB concentration at parturition could negatively affect the productive efficiency of dairy cows.Öğe Serodiagnosis of hydatidosis in sheep and goats in Siirt province, Türkiye, and an alternative approach to the interpretation of serology results(Elsevier BV, 2024-02) Burcak Aslan Celik; Muhammed Ahmed Selcuk; Figen Celik; Ozgur Yasar Celik; Muhammet Uslug; Afra Sena Tekin; Kerem Ercan; Sami SimsekCystic echinococcosis (CE) is one of the most important zoonotic diseases worldwide, affecting both humans and animals, caused by Echinococcus granulosus sensu lato. The diagnosis of CE is based on the evaluation of imaging, serological, molecular and clinical findings. The aim of this study was to develop a diagnostic method that can be used for herd-based diagnosis of CE, which is commonly observed in sheep and goats, and to prevent economic losses by treating positive animals. Antigen B rich partially purified cyst fluid antigen was prepared from a sheep liver hydatid cyst. To determine the sensitivity and specificity of the antigen B-rich partially purified cyst fluid antigen, a Western blot test was first performed using hydatid cyst positive sera from 24 sheep and 20 goats collected from the abattoir and sera from 27 newborn lambs and 23 goat kids as negative controls. Subsequently, 500 sera were collected from 250 sheep and 250 goats from Siirt province and its districts. The strongest band was at 72 kDa, followed by bands at 55 kDa and 28 kDa in SDS-PAGE. According to the 43 kDa band as reference the sensitivity was 62.5 %. and specificity was 96.2 % in sheep. Besides, of the 250 sheep sera collected from the field, and the seroprevalence was 52.80 %. In goats, the sensitivity of WB was 55 % and the specificity was 86.9 %. On the other hand, the seroprevalence was 44.4 % in goats. In conclusion, the production of antigens that are easy to prepare, inexpensive and can be used in field screening for CE will be important in terms of treating positive sheep (even when CE and other helminth parasites are present together) with albendazole and preventing economic losses.Öğe Evaluation of the use of L-carnosine in short-term storage of ram semen with spermatological and flow-cytometric analyzes(Hellenic Veterinary Medical Society, 2024) Güngör, İ.H.; Gür, S.; Koca, R.H.; Cihangiroğlu, A. Çakır; Ekmen, E. Güler; Acısu, T.C.; Badıllı, N.This study was conducted to investigate the effect of adding different doses of L-carnosine to semen in vitro on the short-term storage of semen. Semen taken from 6 Akkaraman rams was used in the research. Semen taken from each animal was pooled. It was diluted with tris+egg yolk extender containing L-carnosine at different doses (1, 5, 10, 20, 50, 100 and 200 mM) and stored at +4°C for 96 hours. Motility and kinematic parameters, abnormal spermatozoa ratio, HOS (Hypo-osmotic swelling test), pH and flow-cytometric analyzes were performed in all experimental groups every 24 hours (0, 24, 48, 72 and 96 hours) during storage. Oxidative stress parameters were determined at 0 and 96 hours. It was determined that 1, 5, 10, 20 mM L-carnosine doses increased total, progressive and rapid motility, kinematic parameters VCL (Curvilinear velocity), VSL (Straight line velocity), VAP (Average path velocity) values and high mitochondrial membrane potential level during short-term storage. It was also determined that these doses protected membrane integrity, reduced the rate of abnormal spermatozoon, acrosomal damage and low mitochondrial membrane potential level. It was determined that a dose of 200 mM L-carnosine had a toxic effect and negatively affected the parameters [total and progressive motility, VCL, VSL, VAP, ALH (Amplitude of lateral head displacement), HOS Test, viability, acrosomal damage, HMMP (High Mitochondrial Membrane Potential), LMMP (Low Mitochondrial Membrane Potential)]. In conclusion, high doses of L-carnosine (200 mM) in semen extenders are harmful to ram semen characteristics after a short time storage. Moreover, low doses of L-carnosine (1, 5, 10 and 20 mM) supplementation may have beneficial effect on ram semen traits, depending on the time storage. © 2024, İH Güngör, S Gür, RH Koca, A Çakır Cihangiroğlu, E Güler Ekmen, TC Acısu, N Badıllı, Ş Özer Kaya, A Yüce, M Sönmez, G TürkÖğe Comparison of serum procalcitonin, haptoglobin and C-reactive protein levels in goats with Corynebacterium pseudotuberculosis(Indian J. Anim. Res, 11.11.2018) Akgül, Mustafa Barış; Özen, Doğukan; Kahya Demirbilek, Serpil; Akgül, GülşahThis study was conducted to investigate the response of acute phase proteins, mainly Haptoglobin, C-reactive protein, Procalcitonin and the negative acute phase response, especially albumin in goats suffering from C. pseudotuberculosis. A total of 19 Turkish hair goats between the ages of 1.5 and 2 years in a special dairy farm was selected for the study, consisting of 9 healthy animals and 10 with C. pseudotuberculosis. There was a statistically significant difference in serum haptoglobin, C-reactive protein, procalcitonin and albumin levels in goats with C. pseudotuberculosis, compared to the control group (p<0.05). The results showed that Haptoglobin, C-reactive protein and Procalcitonin produce a higher, and Alb a lower, response in goats with C. pseudotuberculosis compared to the control. The presented study suggests that C. pseudotuberculosis can influence the level of acute phase proteins in goats. These results indicate that monitoring a number of acute phase proteins can increase the diagnostic information available for this disease.Öğe Comparative evaluations of tear secretion in healthy and infectious keratoconjunctivitis Romanov sheep with Schirmer tear test and phenol red thread tear test(Turkish Journal of Veterinary and Animal Sciences, 20.12.2017) Şındak, Nihat; Gülaydın, Ali; Özen, Doğukan; Kahya, Serpil; Sulu, KadirThe aim of this study is to determine the amount of tear secretion in sheep with infectious keratoconjunctivitis and healthy ones in the Siirt region by Schirmer tear test and phenol red thread tear test. A total of 47 Romanov sheep, consisting of sheep with infectious keratoconjunctivitis (n = 6) and healthy sheep (n = 41), constituted the study material. Phenol red thread tear test followed by Schirmer tear test was performed on both eyes of the animals, properly taken at a control visit on their feet. The Schirmer tear test and phenol red thread tear test values were measured as 18.83 ± 5.29 mm/min and 22.22 ± 6.09 mm/s in the right eyes and 18.41 ± 7.15 mm/ min and 20.83 ± 5.72 mm/s in the left eyes, respectively, in healthy animals. The Schirmer tear test and phenol red thread tear test values were measured as 17.33 ± 4.27 mm/min and 18.83 ± 4.36 mm/s in the right eyes and 17.33 ± 7.55 mm/min and 20.17 ± 4.58 mm/s in the left eyes, respectively, in animals with infectious keratoconjunctivitis. The phenol red thread tear test measurement averages were found to be significantly higher than the Schirmer tear test measurement averages (P > 0.05). The amount of normal tear secretion was determined in Romanov breed sheep by the phenol red thread tear test and Schirmer tear test and there was no statistically significant difference in animals with infectious keratoconjunctivitis (P > 0.05).Öğe Diyarbakır’ın Dicle ve Hani İlçelerindeki Köpeklerde Leishmaniasis’in Klinik, Hematolojik ve Biyokimyasal Bulguları, Serolojik Tanısı ve PCR ile Tiplendirilmesi(2015) Çelik, Özgür Yaşar; Sekin, ServetLeishmaniasis, halk arasında tatarcık olarak bilinen Phlebotominae sineklerinin kan emerken bulaştırdıkları, Leishmania spp. tarafından meydana getirilen insan ve hayvanlarda ölümcül olabilen paraziter bir hastalıktır. Ülkemizde Visseral leishmaniasis olguları başta Ege ve Akdeniz bölgeleri olmak üzere bütün bölgelerimizde görülmektedir. Akdeniz ülkelerinde yapılan çalışmalarda köpeklerde Visseral leishmaniasisin oldukça yaygın olduğu ve köpeklerin L.infantum için rezervuar oldukları bildirilmektedir. Bu çalışma Mayıs-Haziran 2013 tarihleri arasında Diyarbakır’ın Dicle (Dede ve Durabeyli köyleri) ve Hani (sergen ve çardaklı köyleri) ilçelerindeki sahipli köpeklerde canine leishmaniasis seroprevalansının araştırılması amacıyla yapılmıştır. Tekniğine uygun olarak 120 köpeğin vena cephalica antebrachii’lerinden EDTA’lı ve EDTA’sız tüplere kan örneği alındı. Alınan örnekler Rapid test, IFAT, PCR ile incelendi ve köpeklerin tamamı leishmaniasis yönünden negatif bulundu. Benzer çalışmaların bölgedeki sahipsiz köpekleri de kapsayacak şekilde yapılmasının daha iyi sonuçlar doğuracağı kanaatindeyiz.Öğe Bir Erkek Keçide Ürolithiazis Olgusu(2014) İçen, Hasan; Şimşek, Aynur; Servet, Sekin; Çelik, Özgür Yaşar; Çakmak, Fırat; Yaman, TuranÇalışmanın materyalini 2-3 gündür idrar yapamama, sancı ve iştahsızlık şikayeti ile Dicle Üniversitesi Veteriner Fakültesi İç Hastalıkları Kliniği’ne getirilen 1,5-2 yaşlı bir erkek keçi oluşturdu. Hastanın klinik muayenesinde ayakta durmakta güçlük, abdominal gerginlik, anal bölge ile prepisyum çevresinde ödem, prepisyumun uç kısmında kuruluk ve küçük taşlar saptandı. Nabız frekansı 119/dk, solunum frekansı 32/dk ve vücut ısı 36.9 °C olarak tespit edilen hayvana, kan ve idrar örneklerinin laboratuar analiz sonuçları ile otopsi bulgularına göre ürolithiazis tanısı konuldu.Öğe Abomasal impaction due to sand accumulation in two cows(2015) Şimşek, Aynur; Sekin, Servet; İçen, Hasan; Koçhan, Akın; ÇELİK, Özgür YaşarIntroduction - Abomasal impaction is rarely encountered in cattle and is characterized by the drying of the abomasal content and the enlargement of the abomasum as a result of the abnormal accumulation of solid matter in the organ. Aim - This manuscript aims at reporting the occurrence of the rarely encountered abomasal impaction in Turkey. Materials and methods - Two five-year-old dairy cows presenting with symptoms of inappetence, lethargy and constipation constituted the material of the study. Based on the clinical symptoms and necropsy findings, the animals were diagnosed with abomasal impaction. Result and discussion - The body temperature, heart rate and respiratory frequency of the animals, which were slightly dehydrated, were within the normal ranges. Abdominal auscultation revealed reduced rumen contractions and bowel sounds were not heard. On palpation of the right abdominal wall, a large and hard mass was detected, while percussion was associated with a moaning sound. Post-mortem examination revealed the presence of a blood-tinged, dry abomasal content of hard consistency, composed of roughage and foreign substances, including soil, sand and gravel. Conclusion - In animals given feed and water containing mud or sand, sand may accumulate in the abomasum and lead to fatal impaction cases, resulting in significant economic losses. Animals displaying signs of chronic weight loss, ruminal tympany and constipation are recommended to be evaluated for abomasal impaction.Öğe Prevalence of Dirofilaria immitis, Ehrlichia canis, Borrielia burgdorferi infection in dogs from Diyarbakir in Turkey(2011) İçen, Hasan; Şimşek, Aynur; Koçhan, Akın; ÇELİK, Özgür Yaşar…Öğe Kedi ve Köpeklerde Kardiyovasküler Hastalıkların Tanısında Natriüretik Peptidler’in Önemi(2009) İçen, Hasan; Çelik, Özgür Yaşar; Şimşek, AynurKalp yetmezliği ile ilgili hastalıkların patofizyolojisinin anlaşılması ve sağaltımı hakkında son yıllarda oldukça fazla ilerlemeler kaydedilmiştir. Hastalığın tanısında detaylı fiziksel muayeneler yapılmasına rağmen kedi ve köpeklerde yine de zorluklarla karşılaşılmaktadır. Kalp hastalıklarının klinik tanısında; anamnez, fiziksel muayene, kardiyopulmoner oskültasyon ve göğüs radyografisinden yararlanılmaktadır. Tanıda daha çok anlam ifade eden ekokardiyografi kullanımı ve uygulaması uzmanlık gerektirmekte ve aynı zamanda hayvan sahibine ek bir maliyet yüklemektedir. Bu nedenle serum biyomarkırları kalp hastalıklarının tanısı ve sağaltıma verilen cevabın belirlenmesinde kullanılmaktadır. Natriüretik peptidler kalp hastalıklarının tanısında önemli bir yer tutmaktadırlar. Natriüretik peptidler; natriürezisi, idrar üretimini ve böbrek kan akımını arttırırken, sistemik damar direncini ve kalpte dolum basıncını azaltarak diyastololik fonksiyonu etkilemektedir. Kalp hastalıklarının tanısı belirlemede önemli bir protein olmasından dolayı natriüretik peptidlerin kullanımı gittikçe yaygınlaşmaktadır. Bu derlemenin amacı; kalp hastalıklarının tanısında natriüretik peptidlerin etkinliğinin irdelenmesi amaçlanmıştır.
