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Öğe The effects of intravenous lipid emulsion therapy in the prevention of depressive effects of propofol on cardiovascular and respiratory systems: an experimental animal study(25.11.2018) Doğanay, Fatih; Ak, Rohat; Alışkan, Halil; Abut, Serdar; Sümer, Engin; Onur, ÖzgeBackground and objectives: Although there are several hypotheses about the mechanism of action, intravenous lipid emulsion (ILE) therapy has been shown to be effective in the treatment of toxicities due to local anaesthetics and many lipophilic drugs. In this study, we had hypothesized that ILE therapy might also be effective in preventing mortality and cardiorespiratory depressant effects due to propofol intoxication. Materials and methods: Twenty-eight Sprague-Dawley adult rats were randomly divided into four groups. Saline was administered to the subjects in the control group. The second group was administered propofol (PP group); the third group was administered ILE (ILE group), and the fourth group was administered propofol and ILE therapy together (ILE+PP group). Systolic blood pressure (SBP), diastolic blood pressure (DBP), respiratory rate (RR), heart rate (HR), and mortality were recorded at 10 time-points during a period of 60 min. A repeated measures linear mixed-effect model with unstructured covariance was used to compare the groups. Results: In the PP group; SBP, DBP, RR, and HR levels declined steadily; and all rats in this group died after the 60-min period. In the ILE+PP group, the initially reduced SBP, DBP, RR, and HR scores increased close to the levels observed in the control group. The SBP, DBP, RR, and HR values in the PP group were significantly lower compared to the other groups (p < 0.01). The mortality rate was 100% (with survival duration of 60 min) for the PP group; however, it was 0% for the remaining three groups. Conclusions: Our results suggest that the untoward effects of propofol including hypotension, bradycardia, and respiratory depression might be prevented with ILE therapy.Öğe Novel approach to study dispersion in growth and dissolution rate of crystals from solutions(2019) Kaya, Mustafa; Ceyhan, Abdullah; Abut, Serdar; Şahin, ÖmerGrowth and dissolution rate dispersion of boric acid single crystal was investigated in supersaturated and undersaturated solution contained in a specially designed cell by in situ examination of crystals mounted at the tip of a needle, rotated between 0° and 360°, and using an image analyzer system. Changes in the behavior of equivalent crystal diameters at different supersaturation and undersaturation and rotation angles were determined by using two new procedures: (1) rotating growing or dissolving crystals by 360° at intervals of 45° (Procedure 1: angular growth/dissolution rates), and scanning individual face at increments of 10° in the 360° range (Procedure 2: point growth/dissolution rates). It was found that: (1) dispersion in angular growth and dissolution rates is a general phenomenon due to different growth and dissolution rates of individual faces of a crystal, but this dispersion is reduced when the average growth and dissolution rates of all faces are taken into account, and (2) the point growth/dissolution rates of single crystal, calculated by procedure 2, are different from point to point.
