Yazar "Turkoglu, Semra" seçeneğine göre listele

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    Antioxidant and antimicrobial activities of Turkish endemic Achillea species
    (Academic Journals, 2010) Turkoglu, Ismail; Turkoglu, Semra; Celik, Sait; Kahyaoglu, Mustafa
    This study was undertaken to examine in vitro antioxidant, radical scavenging and antimicrobial activities of extracts of Achillea schischkinii Sosn. and Achillea teretifolia Waldst. and Kitt (Asteraceae). The plant materials were extracted in methanol, water and chloroform using rotary evaporator apparatus. The extracts were screened for antioxidant activity using the ABTS radical scavenging capacity, DPPH radical scavenging capacity, superoxide anion radical scavenging, hydrogen peroxide scavenging and metal chelating activities and compared to standard antioxidants. The results obtained in this study indicate that A. schischkinii and A. teretifolia are potential sources of natural antioxidants, antimicrobial activity screening was performed by the disc diffusion method against 6 bacteria strains and 2 yeast species. A. teretifolia displayed strong inhibitory effects against Pseudomonas aeruginosa. The A. teretifolia extract also showed antimicrobial activity against Saccharomyces cerevisae. I contrast, the A. schischkinii extract showed no antimicrobial activity against gram-positive and gram-negative bacteria nor against yeast.
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    Öğe
    Hepatoprotective effects of safranal on acetaminophen-induced hepatotoxicity in rats
    (De Gruyter Poland Sp Z O O, 2024) Alayunt, Naci Omer; Parlak, Akif Evren; Turkoglu, Semra; Tas, Fatih
    This research aimed to explore the protective and therapeutic properties of safranal in mitigating inflammation and oxidative stress induced by elevated acetaminophen (APAP) doses in a rat model. The protective and therapeutic effects of safranal were determined by histopathologically and examining some biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), glutathione, glutathione peroxidase, catalase, malondialdehyde, interleukin-6, tumor necrosis factor-alpha, and interleukin-1 beta. Male Wistar-Albino rats were subject to random allocation, forming five groups, each comprising seven rats (n = 7) in the study. Group 1 was the control group. APAP was administered in Group 2 to induce hepatotoxicity. Rats in Groups 3, 4, and 5 received intraperitoneal injections of safranal at doses of 0.025, 0.05, and 0.1 mL/kg/day for 14 days, respectively. On the 15th day, to induce APAP-induced hepatotoxicity, four groups (Groups 2, 3, 4, and 5) acquired a single intraperitoneal injection of 600 mg/kg APAP. The presence of APAP-induced hepatotoxic effect was proven by elevated AST and ALT levels, which are typical biomarkers of liver function in addition to the demonstration of histopathological changes. The findings suggest that pre-treatment with safranal may offer a protective effect against hepatotoxicity by attenuating oxidative stress and the inflammatory response.