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    Effect of carbon tetrachloride (CCl4) and ellagic acid on rat erythrocyte G6PD, 6PGD, GR, GST and TrxR enzyme activities
    (Parlar Scientific Publications, 2019) Akkoyun, Mahire Bayramoglu; Turan Akkoyun, H.
    In presented study, in vivo effects of the important polyphenol ellagic acid and CCl4 compound known for its toxic effects on metabolic activity levels of some rat erythrocyte enzymes such as G6PD (glucose 6-phosphate dehydrogenase), 6PGD (6-phosphogluconate dehydrogenase), GR (Glutathione reductase), TrxR (Thioredoxin reductase) and GST (Glutathione S-transferase) were investigated. G6PD enzyme activity meaning rised in CCl4 group and ellagic acid+CCl4 group compared to the control group (p<0.001). 6PGD enzyme activity decreased in CCl4 applyed group compared to control group (p<0.05). The enzyme activity level increased in ellagic acid (p<0.05) and CCl4+ellagic acid (p<0.01) applied groups. An increase was observed in ellagic acid (p<0.001) and CCl4+ellagic acid (p<0.001) applied groups compared to CCl4 administered group. GST enzyme activity reduced in CCl4 applied group compared to control group (p<0.01). GR enzyme activity decreased significantly in CCl4 and ellagic acid groups compared to control group (p<0.05 and p<0.01). TrxR enzyme activity decreased in CCl4 group and ellagic acid administered group compared to control group (pO.OOl). A decrease in CCl4+ellagic acid group compared to control was also observed (p<0,001). © by PSP.
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    Öğe
    Effect of quercetin on selected micro elements in rat liver tissue during carbon tetrachloride exposure
    (Parlar Scientific Publications, 2019) Turan Akkoyun, H.; Akkoyun, Mahire Bayramoglu
    The aim of this study was to investigate the effects of carbon tetrachloride and quercetin on selected trace element levels such as Cr (Chromium), Mn (Manganese), Fe (Iron), Cu (Copper) in rats. In the study, 28 male Wistar albino rats (200 ± 300 g) were used. Rats were divided into 4 groups as Control, CCl4 (carbon tetrachloride), Qu (quercetin), Qu + CCl4 (quercetin + carbon tetrachloride) (n=7 in each group). When Cr (ug/g) amount was examined an increase was observed in Qu administered group (p <0.01) compared to the control. It was increased in Qu (p <0.05) and CCl4 + Qu (p <0.001) treated groups compared to CCl4 group. Mn decreased in CCl4 and CCl4 + Qu groups compared to control. Fe (ug/g) content was increased in CCU, CCl4 + Qu and Qu (p<0.01) groups compared to Control. An increase in Qu treated group compared to CCl4 applied group (p<0.05) was observed. The CCl4 + Qu group decreased compared to the Qu group (p<0.01). Cu content of CCl4 and Qu groups showed an increase whereas CCl4 + Qu applied showed a decrease compared to control. As a result; It is thought that quercetin may have an effect on important trace element levels such as Cr (Chromium) Mn (Manganese), Fe (Iron), Cu (Copper) in the case of oxidative stress caused by carbon tetrachloride. © by PSP.