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    Evaluation of CBC, Lipid Profile, Oxidative Stress Biomarkers, Total Thiol, Native Thiol, and Disulfide Levels in Dogs Diagnosed with Parvoviral Enteritis Without Clinical Findings
    (2022) Kurtdede, Efe; Börkü, Mehmet Kazım; Gür, Berna; Doğan, Yalçın; Sevim, Kadir; Gülendağ, Erman
    In this study, whole blood cell count, metabolic and inflammatory biomarkers, and oxidative stress parameters were evaluated in dogs diagnosed with canine parvoviral enteritis by stool antigen testing performed 24-48 hours before any clinical findings arose. This study aimed to conduct effective evaluations of the status of the disease, the selection of treatment methods, and the prognosis of the disease. Thirty dogs with canine parvoviral enteritis positivity according to stool antigen test results 24-48 hours before the appearance of any clinical signs associated with parvo- viral enteritis (lethargy, vomiting, diarrhea, dehydration) were evaluated together with 10 healthy dogs. In analyses of the dogs with canine parvoviral enteritis, significant decreases were found for white blood cell (P < .001), neutrophil (P < .001), and monocyte (P = .011) counts and significant increases were found for alanine aminotransferase and aspartate aminotransferase (P < .001 for both). Significant increases (P < .001) were also determined for high-density lipoprotein, choles- terol, and triglyceride levels among the studied lipid metabolites and C-reactive protein, malondi- aldehyde, and paraoxonase-1 among inflammatory biomarkers. Significant decreases were found for total thiol (P = .002) and native thiol (P < .001), with which antioxidant levels were evaluated, and a significant increase was found for disulfide (P < .001), with which oxidation was evaluated. It was concluded that early changes in blood samples taken 24-48 hours before the onset of clinical symptoms in dogs with CPV, as reflected by values of CBC and metabolic and inflammatory bio- markers, may provide information about the severity of the disease, the choice of medical treat- ments to be applied, and prognosis.