Yazar "Sadik, Betul" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • [ X ]
    Öğe
    A broad assessment of Eremurus spectabilis M. Bieb: chemical and elemental composition, total phenolic and antimicrobial activity analysis, and quantum chemical calculations of radical scavenging potential
    (Taylor & Francis Ltd, 2024) Tegin, Ibrahim; Hallac, Bulent; Sabanci, Nazmiye; Sadik, Betul; Fidan, Mehmet; Yabalak, Erdal
    Eremurus spectabilis M. Bieb was extensively investigated experimentally and theoretically, including the antioxidant properties of compounds such as flavonoids, hydroxycinnamic acid derivatives, hydroxybenzoic acid derivatives, and organic acids. Antioxidant activity was investigated using the Density Functional Theory (DFT) method based on three known mechanisms: hydrogen atom transfer (HAT), single electron transfer followed by proton transfer (SET-PT), and sequential proton loss electron transfer (SPLET). Subcritical water extraction (SWE), soxhlet extraction (SE), and solvent extraction (SOE) techniques were applied in the extraction process. Malic acid was the major compound with an extract concentration of 38,532.84 +/- 1849.58 mu g analyte/kg, total phenolics, and free radical scavenging activity were 10.67 mg gallic acid/mL extract and 73.89% per mg/mL extract, respectively. P, Fe, Na, Mg, K, and Ca were the main elements. The antibacterial activity of E. spectabilis against seven bacteria was evaluated, and it was found to be higher than the commercial antibiotics P10 and AMC30.
  • [ X ]
    Öğe
    EVALUATION OF CHEMICAL CONTENT AND RADICAL SCAVENGING ACTIVITY OF ALLIUM VINEALE L. EXTRACT AND ITS ELEMENTAL ANALYSIS
    (Editura Acad Romane, 2019) Tegin, Ibrahim; Yabalak, Erdal; Sadik, Betul; Fidan, Mehmet
    Allium vineale L. was extensively analysed to determine its radical scavenging activity, chemical composition, total polyphenol content, and elemental composition. The Soxhlet and the subcritical water extraction methods were performed for the extraction procedure. The extracts obtained in the subcritical water extraction method were evaluated by GC-MS. 11 compounds were determined according to mass spectral libraries of GC-MS, Wiley7Nist05.L, NIST05a.L, W9N11.L. The obtained compounds were evaluated for their benefits on health according to literature. DPPH inhibition of Allium vineale L. was obtained as 58.60 % and the total polyphenol content of Allium vineale L. was obtained as 12 mu g/mL gallic acid equivalent. 28 elements were obtained in the elemental analysis by ICP-MS, using the microwave digestion procedure. UHPLC-ESI-MS/MS analysis was performed for the evaluation of methanolic extract of Allium vineale L. obtained in the Soxhlet extraction method.
  • [ X ]
    Öğe
    Unlocking the potential of Allium dictyoprasum CA Meyer ex Kunth: quantum chemical insights into radical scavenging, chemical composition, phenolic content, and antimicrobial activity
    (Taylor & Francis Ltd, 2024) Tegin, Ibrahim; Yabalak, Erdal; Hallac, Bulent; Sabanci, Nazmiye; Fidan, Mehmet; Sadik, Betul
    Allium dictyoprasum C.A. Meyer ex Kunth (A. dictyoprasum) underwent comprehensive analysis, encompassing quantum chemical computations to assess its radical scavenging potential, chemical and elemental composition, total phenolic content, and antimicrobial activity. Experimental and theoretical investigations focused on elucidating the radical scavenging properties of polyhydroxy phenolic compounds present in the plant. Quantum chemical calculations were employed to evaluate the antioxidants employed to evaluate selected polyhydroxy phenolic molecules including flavonoids, hydrocinnamic acid derivatives, and hydroxybenzoic acid derivatives from natural sources. Thermochemical parameters of these compounds were calculated by the B3LYP/6-311 G++(d,p) level in both gas and solvent phases to elucidate the radical scavenging mechanism including hydrogen atom transfer (HAT), single electron transfer followed by proton transfer (SET-PT) and sequential proton loss electron transfer (SPLET). Analysis of A. dictyoprasum extracts obtained via various extraction methods revealed the presence of several major compounds, including dimethyl trisulfide, 3,5-Dihydroxy-6-methyl-2,3-dihydro-4 H-pyran-4-one, 2-Methoxy-4-vinylphenol, Dimethyl phthalate, Methyl palmitate, Methyl oleate, Methyl stearate, (9Z)-9-Octadecenamide. Notably, Malic acid and Quinic acid were identified as major compounds, with concentrations of 43.31 and 17.47 mg kg(-1) extract, respectively, based on LC-MS/MS analysis. The total phenolic content of the extract was measured as 17.83 mg gallic acid/mL, while its free radical scavenging activity was 80.89% per mg/mL. Elemental analysis revealed significant levels of Mg, K, Na, Fe, and P, with minor concentrations of elements such as Ti, Tl, B, and Be. Furthermore, A. dictyoprasum exhibited notable antibacterial activity against various bacteria strains, surpassing the efficacy of some commercial antibiotics. HIGHLIGHTS Quantum chemical calculations of radical scavenging analysis were performed. Thermochemical parameters were calculated by the B3LYP/6-311 G++(d,p) level. Radical scavenging mechanism was evaluated based on HAT, SET-PT and SPLET. Chemical composition of Allium dictyoprasum C.A. Meyer ex Kunth was determined. A. dictyoprasum has a greater antibacterial effects than some commercial antibiotics.