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    Honamli Goats Breed in South of Turkey I- Serum Mineral Analysis
    (2020) Demir, Ayşe Özge; İrak, Kıvanç; Mert, Handan; Mert, Nihat; Ayşin, Nesrullah; Söğütlü, İnci
    The objectivity of this study was to investigate some blood minerals and parameters in Honamli goats reared under semi-intensive conditions. 90 goats (2-4 ages) in different three herds kept under similar manage mental conditions were chosen as research materials in Teke Border of Antalya Province. Serum Ca 6.786±0.206 mg/dL, P 4.094±0.173 mg/dL, Cl 111.105±0.582 mmol/L, K 4.519±0.066 mmol/L, Mg 2.161±0.05 mg/dL, Na 148.047±0.508 mmol/L, Fe 110.706±2.510 ?g/dL, UIBC 155.025±4.333 ?g/dL and Tp 7.055±0.120 g/dL were determined by Roche Diagnostics, Cobas 8000 modular analyser series, immunoassay. After then, total iron- binding capacity (TIBC), transferrin (Tf), transferrin saturation (TSAT) and Ca++ levels were calculated from each other using different biochemical formulas. Ratios between the some minerals were calculated and presented in the text. Also, very high significant differences (P<0.0001) were found between herds for P, Cl, TIBC and Tf. However, no significant differences were found for Ca, Na, TSAT, TP and Ca results. Coefficients of variation (CV) were within 2 % and 35 % for all outcome parameters. In Pearson correlation analysis, negative and different two significant values (P<0.01 and P<0.001) were calculated between Fe and unsaturated iron binding capacity (UIBC) for all analysed groups. Controversially, positive and very high significant correlations (P<0.0001) were detected between Cl and Na. The results obtained from this study could serve as reference values for Honamli goats breeding in Mediterranean Region of Turkey.
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    Öğe
    The Effects of Grape Seed Extract on Insulin, Adiponectin and Resistin Levels in Diabetic Rats
    (2021) Söğütlü, İnci; Mert, Nihat; Mert, Handan; Mis, Leyla; Yılmaz, Halil Cumhur; İrak, Kıvanç
    In this study, the effects of grape seed extract on insulin, adiponectin and resistin levels in diabetic rats were aimed to investigate. Weight of about 300-350g 7-8 weeks 32 female Wistar Albino rats were used. Weight of about 300-350g 7-8 weeks 32 female Wistar Albino rats randomly divided into four groups of eight each: control group (C), group with diabetes (DM), grape seed extract group (GSE), diabetes mellitus and grape seed extract group (DM+GSE). The diabetic group 45 mg/kg single dose of streptozotocin was administered intraperitoneally, and the grape seed extract groups (DM+GSE and GSE) grape seed extract was given orally every day with an intragastric tube for 20 days (0.6 ml/rat). Blood samples were taken from the hearts of rat’s end of the experiment. The sera obtained were used for insulin, adiponectin and resistin analysis measured via ELISA with commercial kits. The insulin and adiponectin levels of the rats in the diabetes + grape seed extract group were found to be higher than those in the diabetes group. There was no significant change in the resistin level differences between the groups. As a result; It is possible to say that grape seed extract has an increasing effect on insulin level and adiponectin levels of diabetic rats are decreased due to diabetes and it has no significant effect on resistin levels. Detected by the positive effects of grape seed extracts, it may be useful to use for the regulating of the diabetes in human.