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Öğe CA 19-9, CA 125, CEA, GLUCOSE, INSULIN AND ACTH LEVELS IN PATIENTS WITH GASTRIC CANCER(2016) İRAK, Kıvanç; MERT, Handan; DOĞAN SÖĞÜTLÜ, İnci; MERT, NihatGastric tumor remains a major health hazard during the decades. Generally it is the third most common cases and has high mortality rates. In the presented study it was aimed to investigate the serum levels of CA 19-9, CA 125, CEA, insulin, glucose and ACTH in patients with gastric cancer. The blood samples of 22 male (45-74 ages old), 12 female (50-75 years old) and 15 healthy subjects were taken before the breakfast and sera were seperated and all analyzed were done immediately. The CA 19-9, CA 125, CEA levels were found in healthy and patients with gastric cancer as 2.09-17.32 ng/ml, 6.94-63.21 U/ml, 9.31-49.71 U/ml respectively. The differences between the groups of these three parameters were statistically significant (p?0.01). The fasting blood glucose and insulin amount were found in normal and cancer cases as, 83.14- 98.33mg/dl (p?0.05), 10.22-8.17 µU/ml (p?0.05) respectively. ACTH levels were slightly higher in cancer patients compared with controls 58.31- 44.28 pg/ml (p?0.05). Tumor markers were increased in all patients with gastric cancer. Some of the patients had diabetic pattern but blood glucose levels over 120 mg/dl were only documented in 8 cases. The results were evaluated clinic pathologically. As conclusion all analyzed parameters were changed in gastric cancer cases. Insulin and ACTH hormones can be properly assessed during the various stages of cancer. As far, we can still use CA 19-9, CA 125, CEA as a reliable tumor markers in gastric cancer.Öğe DETERMINATION OF THE LEVEL OF SOME VITAMIN IN WHEATGRASS AND GRASS(2016) İRAK, Kıvanç; MERT, Handan; YÖRÜK, İbrahim Hakkı; DOĞAN SÖĞÜTLÜ, İnci; MERT, Nihat…Öğe INVESTIGATION OF ANTIOXIDANT COMPOUNDS IN FLUOROTIC SHEEP(2016) DOĞAN, İnci; MERT, Handan; İRAK, Kıvanç; MERT, NihatAbstract Fluorosis, a condition which usually affects the formation of bone and teeth in human and animals, is an important health problem in Van and Agri provinces. This study was performed to determine the levels and the changes of antioxidant compounds in fluorotic sheep. 30 fluorotic sheep and 20 healthy Morkaraman sheep of 3-4 years old were used as living research materials. The diagnosis of fluorosis was confirmed by clinical examinations. The urine fluoride level was determined. Blood of all animals was taken from vena jugularis by appropriate techniques and analyzed for glutathione peroxidase (GPx), glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), sialic acid (SA) and lipid-bound sialic acid (LSA). The levels of these parameters in healthy and fluorotic group were: 1028-416.8 mU /ml, 23.23-50.16 mg/ dl, 9.25- 7.88 mU/ ml, 1.62-0.56 nmol/ ml, 51.19-46.33 mg/ dl and 9.77- 12.16 mg/dl, respectively. Urine fluoride (F) levels were 1.65 ppm in healthy and 23.84 ppm in fluorotic sheep groups. Statistical differences was found between the average values of healthy and fluorotic groups as p? 0.0001 in GPx and GSH, p?0.001 in MDA, p?0.05 in SA, p?0.01 in LSA and p?0.001 in urine F levels. No statistical differences were found in SOD levels. (p?0.05) The results obtained in this study indicate that important changes were found in antioxidant systems of fluorotic sheeps.Öğe THE LEVELS OF NITRITE, NITRATE AND VITAMIN D3 IN HUMAN WITH GASTRIC CANCER(2016) İRAK, Kıvanç; MERT, N; MERT, Handan; COMBA, Bahat; DOĞAN, İnci; YÖRÜK, İbrahim HakkıStomach cancer is one of the most observed in Van and surroundings. Dietary source of Vitamin D are hepfull to survive from cancer with low mortality rates. There are so many reports on the association between nitrate intake from food and gastric cancer risk and also nitrate intake from water. The blood samples were taken patients with stomach cancer admitted to Department of Medical Oncology in Faculty of Medicine in Van. Ranging from 45-76 years old of age 32 male, 15 female patients with a total 47 were used in the research. Stomach adenocarcenoma were diagnosed from all patients with endoscopic biopsy. Then the chest X-Ray, abdominal computed tomography, biochemical and heamatological analysis were done and magnetic resonance were used when it is necessary for grading. The changes of blood parameters after 3-4 cycles of chemotherapy compared to the values at the diagnosis time were analyzed. The blood samples were taken after chemotherapy and analyzed for nitrate, nitrite spectrophotometrically and vitamin D by HPLC. Comparing with control group, the nitrite levels were increased in cancer patients before and after the chemotherapy. But the levels of nitrate were high before chemothrapy then decreased after chemotherapy. Vit D levels of two groups were low then the controls. These three compounds were significantly important for gastric cancer formation in this cases.Öğe SERUM BIOCHEMICAL AND HISTOPATHOLOGICAL EXAMINATIONS OF SOME TISSUES OF LAMBS WITH MUSCULAR DYSTROPHY IN VAN(2016) YILDIRIM, Serkan; İRAK, Kıvanç; MERT, Handan; DOĞAN, İnci; MERT, NihatWhite muscle disease (WMD), is an important disease also known as ‘muscular dystrophy’ in the lamb and calf. White muscle disease is the result of degeneration of skeletal and cardiac muscles in lambs. Lambs mostly affected with the congenital form either born death or die a few day after birth. The disease is a manifestation of lack of selenium, vitamin E or both. Van and surrounding villiages were visited and lambs with WMD examined. The lambs with 3-10 days of age were used as research materials. Necropsy and gross examinations was performed to all lambs. The blood samples were analyzed for Vitamin E amount, Creatine kinase (CK), Aspartate aminotransferase (AST) and Lactate dehydrogenase (LDH) activities. The level of Vitamin E was decreased, but the other parameters significantly increased. In heart, chest and gluteal muscle lesions in lambs were found. Tissue samples were histopathologically examined. Muscular dystrophic calcification in necrotic areas as well as hyaline degeneration and Zenker necrosis were determined. In the calcified region mononuclear cell infiltration mainly macrophages, were observed. In conclusion in lamb with white muscle disease; the activities of enzymes related to muscle health were raised drastically. In gluteal, chest and especially in heart muscle the hyalin and Zenker degeneration were noted.
