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    Öğe
    Differential in vitro inhibition studies of some cerium vanadate derivatives on xanthine oxidase
    (Taylor & Francis Ltd, 2015) Kaya, Mustafa Oguzhan; Kaya, Yesim; Celik, Gulsah; Kurtulus, Figen; Arslan, Oktay; Guler, Ozen Ozensoy
    In this preliminary study, a new series of some cerium vanadate derivatives have been investigated as new type of inhibitors of xanthine oxidase (XO; E.C 1.17.3.2). XO is a superoxide-producing enzyme found normally in serum and the lungs, and its activity is concerned with several important health problems such as gout, severe liver damage, vascular dysfunction and injury, oxidative eye injury and renal failure. In this study, we present a critical overview of the effects of these novel type agents on XO with comparing the efficacy and safety profiles of allopurinol, the efficient classical inhibitor of XO.
  • [ X ]
    Öğe
    In vitro effects of novel type M-V-O derivatives on Xanthine Oxidase
    (C M B Assoc, 2017) Kaya, Mustafa Oguzhan; Gul, Gulsah Celik; Kurtulus, Figen
    Xanthine Oxidase (XO) is related with different diseases such as vascular, gout, nephropathy and renal stone diseases that are relevant to high uric acid levels and oxidative stress. Some common natural inhibitors of xanthine oxidase are known as rosmarinic acid and apigenin. With this study, we aimed to determine inhibitory effects of originally synthesized new generation transition metal vanadates on Xanthine Oxidase (XO) from bovine milk. Because, Xanthine oxidase inhibitors are typically used in the treatment of gout and nephropathy and renal stone diseases linked to hyperuricaemia. We found considerable IC50 constants for inhibition of XO. Among the synthesized compounds, Cu-V-O was found to be the most active (IC50 = 7.119 mM) for inhibition of XO.