Yazar "Kurtdede, Efe" seçeneğine göre listele

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    Evaluation of CBC, Lipid Profile, Oxidative Stress Biomarkers, Total Thiol, Native Thiol, and Disulfide Levels in Dogs Diagnosed with Parvoviral Enteritis Without Clinical Findings
    (2022) Kurtdede, Efe; Börkü, Mehmet Kazım; Gür, Berna; Doğan, Yalçın; Sevim, Kadir; Gülendağ, Erman
    In this study, whole blood cell count, metabolic and inflammatory biomarkers, and oxidative stress parameters were evaluated in dogs diagnosed with canine parvoviral enteritis by stool antigen testing performed 24-48 hours before any clinical findings arose. This study aimed to conduct effective evaluations of the status of the disease, the selection of treatment methods, and the prognosis of the disease. Thirty dogs with canine parvoviral enteritis positivity according to stool antigen test results 24-48 hours before the appearance of any clinical signs associated with parvo- viral enteritis (lethargy, vomiting, diarrhea, dehydration) were evaluated together with 10 healthy dogs. In analyses of the dogs with canine parvoviral enteritis, significant decreases were found for white blood cell (P < .001), neutrophil (P < .001), and monocyte (P = .011) counts and significant increases were found for alanine aminotransferase and aspartate aminotransferase (P < .001 for both). Significant increases (P < .001) were also determined for high-density lipoprotein, choles- terol, and triglyceride levels among the studied lipid metabolites and C-reactive protein, malondi- aldehyde, and paraoxonase-1 among inflammatory biomarkers. Significant decreases were found for total thiol (P = .002) and native thiol (P < .001), with which antioxidant levels were evaluated, and a significant increase was found for disulfide (P < .001), with which oxidation was evaluated. It was concluded that early changes in blood samples taken 24-48 hours before the onset of clinical symptoms in dogs with CPV, as reflected by values of CBC and metabolic and inflammatory bio- markers, may provide information about the severity of the disease, the choice of medical treat- ments to be applied, and prognosis.
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    Evaluation of the combined effects of Turkish mad honey and 5-Fluorouracil in colon cancer model in rats
    (Ankara Univ, 2023) Kurtdede, Efe; Alcigir, Mehmet Eray; Alperen, Ahmet Mahmut; Baran, Berk; Karaca, Oguz Kaan; Gulendag, Erman
    It was aimed to evaluate the regressive effect of grayanotoxin-rich Turkish mad honey and 5-fluorouracil (5-FU), separately and together by using the Nmethyl-N-nitrosourea (MNU)-induced colon cancer modelling in rats. Study groups were designed as control group (CG), cancer control group (CCG), 5Flourouracil group (FUG), Turkish mad honey group (HG), Turkish mad honey and 5-FU combined group (FU-HG). White blood cell (WBC), lymphocyte, eosinophil, basophil, serum lactate dehydrogenase (LDH), total oxidant status (TOS), and total protein values of the rats in the CCG were significantly lower than the values of the rats in the CG, whereas serum Bcl-2 and survivin levels were significantly higher in the rates belonged to the CCG in comparison to those in the CG. The presence of anaplastic epithelial cells, vascularization, precancerous changes, and inflammatory infiltration detected in the colon and small intestine of the rats in FU-HG, FUG, HG were less intense (P<0.05) compared to the findings in the rats in CCG. In conclusion, mad honey and 5 FU reduced anaplastic cell growth and oxidative stress via suppressed antiapoptotic activity. Considering the histopathological findings in the liver and kidney, no toxicity occurred related to mad honey and 5-FU metabolization. Therefore, the combined use of these two substances may be an alternative method in the treatment of colon cancer.
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    Evaluation of tumor-suppressive properties and apoptotic functions of Mad Honey and Vincristine applications in a rat model of breast cancer
    (Ankara Univ, 2024) Kurtdede, Efe; Alcigir, Mehmet Eray; Alperen, Ahmet Mahmut; Baran, Berk; Kuzu, Necat; Gulendag, Erman
    In this study, the suppressive effects of vincristine and Turkish mad honey alone and in co-applications were biochemically, hematologically, and histopathologically investigated in a mammary tumor model induced with 7,12-dimethylbenz[a]anthracene (DMBA) in rats. A total of 72 rats, 43-49 days old, were divided into 6 groups of 12 rats each. The control group (CG) consisted of healthy rats. The vehicle group (VG) received only vehicle substance and the cancer control group (CCG) was given only DMBA. DMBA and the honey group (HG) given group. DMBA and the vincristine (VinG) given group, and DMBA, the vincristine-honey group (VHG) received both Turkish mad honey and vincristine. Turkish mad honey and/or vincristine was given in the last 4 weeks of the 13-week trial period. White blood cell and lymphocyte counts differed significantly in the CCG and VG groups. Alanine transaminase and total protein levels were higher in the CCG and VinG groups. Aspartate transaminase was higher in the CCG, HG and VG groups. Caspase-3 and Bax protein levels were in the HG and VHG groups significantly higher than CCG. In caspase-8 protein level VHG significantly higher than other groups. Caspase-9 protein level was in CG and VG groups significantly lower than other groups. Bcl-xL increased more in the CCG group. Anaplasia was reduced in the HG and VinG groups, although apoptosis and other cellular damages increased. It was concluded that mad honey and vincristine could be considered together as effective therapeutic agents in this model of DMBA-induced breast cancer.
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    Relationships between the Postpartum Body Condition Score, Colostral IgG Content, Liver Lipid Metabolism and Oxidative Stress in Dairy Cows
    (2022) Kurtdede, Efe; Kurtdede, Arif; Kara, Erdal; Er, Mehmet Ba; Gülendağ, Erman
    His study aimed to evaluate the relationships between the postpartum body condition score (BCS)\rand colostral IgG, lipid metabolism, liver functions and oxidative stress parameters in dairy cows\rwith BCSs of ?3.5 and >3.5.\rThis investigation included 60 dairy cows of the same breed, that were 3-5 years old and had given\rtwo or more births in a dairy farm. Care was taken to ensure that the BCS changes of the cows\rwere <0.5 from the dry period to calving.\rIn the 30 cows with a BCS of ?3.5 within 24 hours of birth, the mean BCS level was 3.24±0.24 and\rthe mean serum ?-hydroxybutyric acid (BHBA) level was 0.36±0.07. In the 30 cows with a BCS of\r>3.5 within 24 hours of birth, the mean BCS level was 3.96±0.14 and the mean serum BHBA level\rwas 0.38±0.07.\rCompared to the values determined in cows with a BCS >3.5, serum non-esterified fatty acids\r(NEFA), high-density lipoprotein (HDL), paraoxonase-1 (PON-1) and malondialdehyde (MDA)\rlevels were significantly lower, and triglyceride, albumin, SOD and colostral IgG levels were\rsignificantly higher in cows with a BCS of ?3.5.\rIt was concluded that a BCS change of <0.5 from the drying period to parturition and a postpartum\rBCS of ?3.5 in dairy cows would be beneficial for better management of the metabolic process,\roxidative stress and high colostral IgG level.