Yazar "Kerimkulova, Aygul" seçeneğine göre listele

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  • [ X ]
    Öğe
    Biological assays and theoretical density functional theory calculations of Rh(I), Ir(III), and Ru(II) complexes of chiral phosphinite ligand
    (Wiley, 2020) Rafikova, Khadichakhan; Binbay, Nil Ertekin; Meric, Nermin; Kerimkulova, Aygul; Zazybin, Alexey; Binbay, Veysel; Okumus, Veysi
    Four metal complexes, IL-OPPh2-Ru-p-cymene (3), IL-OPPh2-Ru-benzene (4), IL-OPPh2-Ir-Cp* (5), IL-OPPh2-Rh-COD (6), have been evaluated for in vitro antioxidant activity such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and reducing power activity. Maximum scavenging activity (71.43%) was obtained with IL-OPPh2-Ru-p-cymene, whereas IL-OPPh2-Rh-COD showed the highest reducing power ability. The complexes were also studied for their antimicrobial activity against three Gram-positive and three Gram-negative bacteria. In addition, DNA binding of the complexes was evaluated using calf thymus DNA. Both Ru(II) complexes exhibited good DNA-binding activity while the other complexes did not have any activity. Furthermore, ab initio quantum calculations of four complexes were also carried out using density functional theory to better understand their chemical behaviors.
  • [ X ]
    Öğe
    Half-sandwich ruthenium(II) and iridium(III) complexes of imidazole based phosphinite ligands: antioxidant and antibacterial activities as well as electrochemical properties
    (Wiley-V C H Verlag Gmbh, 2024) Isik, Ugur; Rafikova, Khadichakhan; Meric, Nermin; Guzel, Remziye; Kerimkulova, Aygul; Akimbek, Arailym; Okumus, Veysi
    Ruthenium(II) and iridium(III) complexes of phosphinites including imidazole moiety were synthesized and characterized by microanalysis, IR, MS, and NMR spectroscopies. Antibacterial activity against Gram-positive and Gram-negative bacterial strains was assessed in all complexes. The highest radical scavenging (72.2 %) was obtained for [3-(3-chloro-2-({[dichloro(eta 6-benzene)ruthenium]diphenylphosphanyl}oxy)propyl)-1-butyl-1H-imidazol-3-ium chloride], 4 at 200 mu g/mL concentration, while [3-(3-chloro-2-({[dichloro(eta 5-pentamethylcyclopentadienyl)-iridium]diphenylphosphanyl}oxy)pro-pyl)-1-butyl-1H-imidazol-3-ium chloride], 6 demonstrated the highest antibacterial activity as 13 mm inhibition zone against E. hirea. Furthermore, optical and electrochemical featured of metal complexes containing imidazole phosphinite were investigated utilizing UV-vis absorption and cyclic voltammetry techniques. Consequently, all complexes can be proposed as metal-based charge convertible phosphinite complexes which may be employed as new generation and synergistic Dye-Sensitized Solar Cell (DSSC) materials. Ruthenium(II) and iridium(III) complexes of phosphinites including imidazole moiety are synthesized and characterized by microanalysis, IR, MS, and NMR spectroscopies. Their antibacterial activity against Gram-positive and Gram-negative bacterial strains is assessed. Furthermore, optical and electrochemical features of the metal complexes are investigated utilizing UV-vis absorption and cyclic voltammetry techniques. image