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    Age-related changes in the pharmacokinetics of meloxicam after intravenous administration in sheep
    (Wiley, 2023) Coskun, Devran; Corum, Orhan; Corum, Duygu Durna; Cetin, Gul; Irmak, Mehmet; Ceyhan, Hatice Rumeysa; Uney, Kamil
    The pharmacokinetics of meloxicam was studied in 1-, 6-, and 12-month- old sheep following a single intravenous (i.v.) dose of 1 mg/kg. The experiments were carried out when the Romanov sheep were 1 month old (7.93 +/- 0.91 kg), 6 months old (27.47 +/- 4.91 kg), and 12 months old (37.10 +/- 3.64 kg). Meloxicam concentration in plasma was determined by high-performance liquid chromatography and the data collected were evaluated by non-compartmental kinetic analysis. Meloxicam was detected in the plasma up to 72 h following i.v. administration in all age groups. The volume of distribution at steady state (Vdss) and total body clearance (ClT) were significantly higher in 1- month- old (304.87 mL/kg and 16.57 mL/h/kg) than in 12- month- old (193.43 mL/kg and 10.50 mL/h/kg) sheep. The area under the concentration- time curve from 0 to 72 h value of meloxicam was lower in 1- month- old (58.51 h*mu g/mL) compared to 12- month- old (92.59 h*mu g/mL) sheep. There was no difference in t1/ 2.z value in different age groups. The body extraction ratio values for meloxicam ranged from 0.0186 to 0.0719 after i.v. administration in all age groups. Meloxicam showed an increase in plasma concentration and a decrease in Vdss and ClT in 12- month- old compared to 1- month- old sheep. Compared to 1- month- old and 12- month- old sheep, there was no difference in these parameters in 6- month- old sheep. Because the age of sheep has an influence on the pharmacokinetics of meloxicam, dosage apparently may need to be adjusted for age.
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    Effects of multi-enzymes supplementation to wheat and soybean meal-based feeds on growth performance, digestibility and carcass characteristics of quails
    (Urmia Univ, 2024) Irmak, Mehmet; Denli, Muzaffer; Kayri, Veysi; Coskun, Isa
    Japanese quail ( Coturnix coturnix japonica) is a popular experimental animal model in scientific research. The present study investigated the effects of dietary multiple enzyme supplementation on growth performance, carcass characteristics, nutrient digestibility and small intestinal histomorphology in quails fed diets based on wheat and soya bean meal. A total number of 192 1-day-old quails were assigned to three treatments with 16 replicates in each and four quails per replicate for 38 days. The control group received a basal diet, and the treatment groups received a basal diet with 0.10 or 0.20% multi-enzyme, respectively. Growth performance parameters, carcass characteristics, nutrient digestibility and small intestinal histomorphology in quails were evaluated. Dietary supplementation of multi-enzymes to diet significantly increased body weight gain and improved the feed conversion rate. Moreover, quails fed with 0.10 or 0.20% multi-enzymes showed better ash digestibility coefficients and apparent metabolizable energy coefficients than the control quails. Furthermore, quails fed on a diet containing 0.20% multi-enzyme had the highest crude fiber digestibility. The villi length and the villi length/crypt depth ratio of the duodenum were significantly increased and the crypt depth was decreased in quails-fed diets supplemented with both multi-enzyme levels. However, feed consumption, carcass yield, carcass weight, heart weight, gizzard weight, liver weight and total intestine weights were not affected by treatments. In conclusion, our results showed that dietary supplementation of multi-enzymes to a wheat and soybean meal-based diet enhanced the growth performance and nutrient digestibility of quails. (c) 2024 Urmia University. All rights reserved.
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    Supplementing Broiler Quail Diets with Dried Egg Yolk under Heat Stress Conditions
    (2024) Irmak, Mehmet; Denli, Muzaffer; Kayri, Veysi; İpçak, Hasan Hüseyin; Oduncu, Ferhat Mazlum; Aldemir, Ezgi
    This study was conducted to investigate the impact of incorporating dried egg yolk into the diet on the growth performance, carcass quality characteristics, and thigh-breast malondialdehyde value of quails (Coturnix coturnix japonica) subjected to heat stress. A total of 160 quails, 10 days old, were divided into four groups, each comprising 10 replicates with four chicks in each group. Throughout the experiment, the quails were provided with isonitrogenic and isocaloric feeds. The experimental groups were as follows: 1) Basic ration without temperature application (Control); 2) Basic ration with 1% added egg yolk, without temperature application; 3) Basic ration with temperature treatment (30 °C for 8 hours per day); and 4) Basic ration with 1% added egg yolk, along with temperature treatment (30 °C for 8 hours per day). At the end of the experiment, the highest body weight gain occurred in male and female quails which fed the diets incorporated with dried egg yolk and not exposed to heat (P<0.05). The males and females that were exposed to heat and fed with the basic ration showed the lowest feed intake, and this difference was statistically significant (P<0.05). There was no significant difference observed in the malondialdehyde (MDA) values of thigh meat on days 3 and 9, as well as in breast meat on days 3, 6, and 9 (P>0.05). However, a significant change in thigh malondialdehyde value was detected on day 6 (P<0.05). In conclusion, the addition of dried egg yolk to the diets of quails exposed to heat stress diminished the negative effects of heat stress on growth performance.