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    Öğe
    Determination of Antimicrobial and Antioxidant Activities of Lavandula angustifolia Volatile Oil
    (2022) Özdemir, Oğuzhan; Yılmaz, Nurten; Gök, Mesut; Kaya, Mustafa Oğuzhan
    This study aimed to evaluate the antimicrobial effect of the oil extracted from Lavandula angustifolia (Province of Denizli/Türkiye) on some gram-negative/positive pathogenic microorganisms and lactic acid bacteria (by agar well diffusion, MIC test), and antioxidant capacity (DPPH, metal chelating, FRAP). As a result of the analysis, it was determined by headspace/GC-MS analysis that eucalyptol was the highest with a value of 22.58%, ?-linalool was the second with a value of 19.44% and linalyl acetate was 14.61%. Lavandulol, an essential component of Lavender, was determined by 1.39%. The highest antimicrobial effect of L. angustifolia oil was found on Bacillus subtilus and Methicillin-resistant Staph. aureus (MRSA) with zone diameters of 24 to 22 mm, respectively), followed by Staph. aureus. Antibacterial effects of L. angustifolia oil on Staph. aureus, E. coli, Campliobacter jejuni, Salmonella poona, Lactobacillus reuteri and Lactobacillus plantarum were detected as 17, 16, 14, 14, 12, 12, and 11 mm zone diameters, respectively. Therewithal, a significant antioxidative effect was determined by DPPH, FRAP, and metal chelating analyzes.
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    Öğe
    Phytochemical profiling, molecular docking and ADMET prediction of essential oil of Ocimum basilicum
    (2025-02-20) Başar, Yunus; Gök, Mesut; Erenler, Ramazan; Demirtaş, İbrahim
    Essential oils are widely used in pharmacology, cosmetics, and food industries, and they also have biological activities such as antioxidant, anti-inflammatory, anti-rheumatic, and antimicrobial. Ocimum basilicum (basil) plant has a rich content of essential oils. Hence, the stem, leaf, and flower parts of the O. basilicum were analyzed freshly on the RSH/GC-MS device to determine the essential oil content. As a result of the analysis, α-elemene, linalool, and eucalyptol were detected as the main components. It was observed that the highest linalool content was in the flower part at 47.85%, and the eucalyptol content was in the leaf part at 44.00%. Additionally, it was determined that the α-elemene content was highest in the flower part with 12.49%. According to the analysis results, high amounts of linalool, eucalyptol, and α-elemene were detected. The inhibitory properties of these compounds against the DNA gyrase enzyme were investigated by molecular docking. MolDock score (-78.72, -47.50, -88.86) and binding energy (2.9, 4.6, 4.0 kcal/mol) of linalool, eucalyptol, and α-elemene compounds were determined respectively. According to the ADME/T properties of the molecules examined; The α-elemene did not show any toxic effects. As a result, the eucalyptol compound may be used as an inhibitor against the DNA gyrase enzyme. In addition, it can contribute to the economy by obtaining essential oils from the non-consumable flowers and stem parts of the basil plant and increasing its usability in industries such as cleaning, cosmetics, etc.