Yazar "Emrah Yerlikaya" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Comprehensive experimental and computational analysis of endemic Allium tuncelianum: Phytochemical profiling, antimicrobial activity, and In silico studies for potential therapeutic applications
    (Elsevier BV, 2025-05) Oğuzhan Özdemir; Nurten Yılmaz; Ahmad Badreddin Musatat; Tuna Demirci; Servet Çete; Emrah Yerlikaya; Mustafa Oğuzhan Kaya
    Allium tuncelianum (TG), an endemic garlic species from Tunceli, Turkey, was investigated using a multidisciplinary approach combining experimental and computational methods. Density Functional Theory (DFT) calculations with B3LYP/def2-SVP/def2-TZVP basis sets were employed to analyze electronic properties, reactivity, and stability under gas and ethanol conditions. Headspace/GC-MS identified 10 major components, with diallyl disulfide (48.03 %) and 1-propene (20.72 %) as predominant. Antimicrobial assays revealed potent activity against MRSA, Salmonella paratyphi A, and E. coli, with MIC values as low as 0.063 mg/mL. Antioxidant capacity, evaluated via DPPH, metal chelating, and FRAP assays, showed promising results, with the water extract exhibiting the highest activity (1.74 mg BHT equivalent/mL). DFT and molecular docking studies highlighted key compounds as potential inhibitors of E. coli Gyrase B, with binding energies of -5.68 and -6.07 kcal/mol. ADME predictions indicated favorable drug-like properties, though some compounds showed potential CYP450 interactions and toxicity. This study provides a comprehensive understanding of TG's biochemical profile and therapeutic potential, offering insights for future research and optimization.
  • [ X ]
    Öğe
    Evaluation of salivary BDNF levels in gingivitis and periodontitis: a preliminary research
    (Springer Science and Business Media LLC, 2025-04-10) Veysel Tahiroglu; Emrah Yerlikaya; Revsa Evin Canpolat Erkan; Hasan Karagecili; Azat Sagin; Nushet Sagin
    Background: Oral health is closely related to physical health, life comfort, and functional needs. Gingivitis is a condition that means hardening of the gum tissue, prone to redness, swelling, or bleeding due to different reasons. Periodontitis damages the soft tissue around the teeth. It is a serious gum infection that destroys the bone that supports a person's teeth, if left untreated. BDNF is a member of the neurotrophin family, playing roles in the survival, growth, and function of neurons in the central and peripheral nervous system. This study aims to determine and compare salivary BDNF levels in individuals with periodontal disease and healthy controls, and to assess its relationship with clinical periodontal parameters. Methods: After the participants were informed and their consent was obtained, unstimulated saliva samples were taken. In our study, experimental and control groups were formed with 30 people in each group. BDNF level was measured in the saliva samples taken. Results: We found no statistically significant difference in age and gender between the healthy group, gingivitis group, and periodontitis group. There was a significant difference in the PI, GI, PPD, CAL, and BOP values in all three groups. No statistically significant difference was found when salivary BDNF levels of the groups included in the study were compared. Conclusions: Demographic and clinical findings recorded in this study support that the amount of BDNF partially affects periodontal health parameters and neurological diseases.