Yazar "El-Safty, Sherif A." seçeneğine göre listele

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    Chipset Nanosensor Based on N-Doped Carbon Nanobuds for Selective Screening of Epinephrine in Human Samples
    (Wiley, 2022) Emran, Mohammed Y.; El-Safty, Sherif A.; Elmarakbi, Ahmed; Reda, Abduallah; El Sabagh, Ayman; Shenashen, Mohamed A.
    Chipset nanosensor design and fabrication are important for healthcare research and development. Herein, a functionalized chipset nanosensor is designed to monitor neurotransmitters (i.e., epinephrine (EP)) in human fluids. An interdigitated electrode array (IDA) is functionalized by N-doped carbon nanobud (N-CNB) and N-doped carbon nanostructure (N-CNS). The surface morphology of N-CNB shows the formation of nanotubular-like branches on sheets and micrometer-size tubes. The N-CNS design consists of the formation of aggregated sheets and particles in nanometer size. The irregular shape formation provides surface heterogeneity and numerous free spaces between the stacked nanostructures. N-atoms ascertain highly active N-CNS with multifunctional active centers, electron-rich charged surface, and short distance pathway. The N-CNB/IDA exhibits the best performance for EP signaling with high sensitivity and selectivity. The N-CNB/IDA sensing performance for EP detection indicates the successful design of a highly selective and sensitive assay with low detection limit of 0.011 x 10(-6) m and a broad linear range of 0.5 x 10(-6) to 3 x 10(-6) m. The N-CNB/IDA exhibits a high degree of accuracy and reproducibility with RSD of 2.7% and 3.9%, respectively. Therefore, the chipset nanosensor of N-CNB/IDA can be used for on-site monitoring of EP in human serum samples and further used in daily monitoring of neuronal disorders.
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    Enzymeless copper microspheres@carbon sensor design for sensitive and selective acetylcholine screening in human serum
    (Elsevier, 2022) Emran, Mohammed Y.; Shenashen, Mohamed A.; El Sabagh, Ayman; Selim, Mahmoud M.; El-Safty, Sherif A.
    Follow up of neuronal disorders, such as Alzheimer's and Parkinson's diseases using simple, sensitive, and selective assays is urgently needed in clinical and research investigation. Here, we designed a sensitive and selective enzymeless electrochemical acetylcholine sensor that can be used in human fluid samples. The designed electrode consisted of a micro spherical construction of Cu-metal decorated by a thin layer of carbon (CuMS@C). A simple and one-pot synthesis approach was used for Cu-metal controller formation with a spherical like structures. The spherical like structure was formed with rough outer surface texture, circular build up, homogeneous formation, micrometric spheres size (0.5 -1 mu m), and internal hollow structure. The formation of a thin layer of carbon materials on the surface of CuMS sustained the catalytic activity of Cu atoms and enriched negatively charge of the surface. CuMS@C acted as a highly active mediator surface that consisted of Cu metal as a highly active catalyst and carbons as protecting, charge transport, and attractive surface. Therefore, the CuMS@C surface morphology and composition played a key role in various aspects such as facilitated ACh diffusion/loading, increased the interface surface area, and enhanced the catalytic activity. The CuMS@C acted as an electroactive catalyst for ACh electrooxidation and current production, due to the losing of two electrons. The fabricated CuMS@C could be a highly sensitive and selective enzymeless sensor for detecting ACh with a detection limit of 0.1 mu M and a wide linear range of 0.01 - 0.8 mM. The designed ACh sensor assay based on CuMS@C exhibited fast sensing property as well as sensitivity, selectivity, stability, and reusability for detecting ACh in human serum samples. This work presents the design of a highly active electrode surface for direct detection of ACh and further clinical investigation of ACh levels.
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    Progress in sensory devices of pesticides, pathogens, coronavirus, and chemical additives and hazards in food assessment: Food safety concerns
    (Pergamon-Elsevier Science Ltd, 2022) Shenashen, Mohamed A.; Emran, Mohammed Y.; El Sabagh, Ayman; Selim, Mahmoud M.; Elmarakbi, Ahmed; El-Safty, Sherif A.
    Food intake gives vitality and supplements to support humans and other living organisms. Food safety and contamination problems associated with food hygiene, storage, chemical additives, enzymes, bacteria, and pesticides are crucial issues because of their direct influence on the health of humans and even animals. New monitoring technologies should be developed for potential food safety and significant environmental benefits. To date, the ultrasensing, early detection, and real- and on-time monitoring of vital reactive species, biomolecules, chemicals, and hazardous agents are important in ensuring food quality. With significant advances in the engineering of sensory devices, the progressive development of accurate quantity screening, early explicit monitoring and assessment, and real-time detection analysis can support the standard food quality through the full control of an extraordinary food safety test. Progress in numerous autoexamining appraisals, sensing protocols, and tools of (i) reactive species and chemical additives associated with human metabolism and various nutritional and industrial processes of foods, including ascorbic acid (AA), H2O2, uric acid (UA), and nitrite and sulfite anions; (ii) extremely organic and inorganic hazards such as heavy metals and bisphenol A; and (iii) food adulteration, pesticides, pathogenic microorganisms are a key challenge for food safety concerns. To date, evidence supporting the possibility of transmitting coronavirus disease 2019 (COVID-19) infection through food products is unavailable. However, in a report on an outbreak in mid-June 2020 in China, food contamination with the causative agent of COVID-19 pandemic, SARS-CoV-2, was discovered. Thus, sensory protocol devices for monitoring the SARS-CoV-2 antigen associated with food products is urgently needed for the future perspective progress in health. As such, we provide details in advanced sensor development in the monitoring, analysis, and evaluation sectors for food safety applications. We also report on next-generation nano/microscale wearable sensor devices that can wirelessly provide relevant healthy and safety food information data. This review gives evidence that the powerful engineering of mobile food sensor devices is an ongoing acquisition, offering considerable future avenues to the perspective in-home healthcare of aging individuals.