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    Effects of pro-inflammatory interleukin-6 and anti-inflammatory interleukin-10 cytokines in pregnant women diagnosed with coronavirus disease 2019
    (2022) Göklü, Mehmet Rifat; Tunç, Şeyhmus; Aksin, Şerif; Andan, Cengiz
    Aim: This study aims to investigate the relationship between serum interleukin (IL)-6 and IL-10 levels in coronavirus disease (COVID)-19 positive pregnant women and the course of the disease. Methods: In our study, serum IL-6 and IL-10 levels were measured in 28 third-trimester COVID- 19-positive pregnant women and 30 third-trimester healthy pregnant women. COVID-19-positive cases were classified as carriers or patients. While 13 of the pregnant women in the study group were asymptomatic or were being followed out due to mild illness; a total of 15 pregnant women, 7 of whom were in the intensive care unit (ICU), were hospitalized and treated. IL-6 and IL-10 tests of COVID-19-positive pregnant women were studied at the time of first application. Results: Seven (25%) patients with COVID-19 required admission to an ICU. The IL-6 level was found to be significantly lower in COVID-19-negative pregnant women compared to pregnant women who were COVID-19 carriers and patients (p=0.01). The IL-10 level was found to be signifi- cantly higher in pregnant women who were negative for COVID-19 compared to pregnant women who were COVID-19 carriers (p=0.002) and patients (p=0.002). Conclusion: Close monitoring of IL-6 and IL-10 cytokine levels is recommended to minimize the risk of adverse outcomes in pregnant women presenting with a suspected or confirmed diagnosis of COVID-19. In this way, it may be possible to distinguish moderate–mild COVID-19 from severe COVID-19 in pregnant women.
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    Postoperative results of laparoscopic lateral suspension operation: A clinical trials study
    (Frontiers Media Sa, 2023) Aksin, Serif; Andan, Cengiz
    BackgroundPelvic organ prolapse surgery carries potential risks, and Laparoscopic lateral suspension (LLS) surgery is being performed in increasing numbers with advances in minimally invasive surgery. Our study aims to report the postoperative results of LLS operations. Patients and Methods41 patients at POP Q stage 2 and above underwent LLS operations in a tertiary center between 2017 and 2019. Postoperative patients 12 (12-37) months and older were evaluated in terms of anterior and apical compartments. ResultsIn our study, laparoscopic lateral suspension (LLS) was applied to 41 patients. The mean age of all patients was 51.45 +/- 11.51, and the operation time was 71.13 +/- 18.70 min, The mean hospital stay was 1.35 +/- 0.4 days. The apical compartment success rate was 78% and the anterior compartment success rate was 73%. In terms of patient satisfaction, 32 (78.1%) patients were satisfied, While 37 (90.1%) patients did not have abdominal mesh pain, 4 (9.9%) patients had mesh pain. Dyspareunia was not observed. ConclusionsLaparoscopic lateral suspension in pop surgery; Considering the success rate below expectation, some patient groups can be applied as an alternative surgical method.