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Öğe Change of Vitamin D Levels According to Age, Gender and Seasons in ??rnak Province(Galenos Publ House, 2023) Tahiroglu, Veysel; Alayunt, Naci OmerObjective: This study determines the 25-hydroxy vitamin D [25(OH)D] profile according to season, age, and gender by examining the vitamin D levels of the patients who applied to Cizre State Hospital, which is the warmest district of Turkey, in 2021.Materials and Methods: 13,387 patients admitted to Cizre State Hospital were included in the study, and their [25(OH)D] levels were analyzed retrospectively. In the study, [25(OH)D] levels were evaluated according to the age, gender and seasonal differences of the patients. [25(OH)D] levels in serum are <12 ng/mL, severe deficiency, 12-20 ng/mL mild-moderate deficiency, 21-30 ng/mL insufficient, >30 ng/mL conditions were accepted as qualifications. Results: The findings of 9,800 women and 3,587 men were evaluated in the study. The mean serum level of [25 (OH)D] was 12.31 +/- 0.08 ng/ mL in women and 17.58 +/- 0.15 ng/mL in men. Amongst the age groups, vitamin D levels in both male and female patients were statistically significant (p<0.01). Statistically significant changes were identified across seasons, with [25(OH)D] levels in both women and men being lowest in winter and greatest in summer (p<0.01).The mean [25(OH)D] level was 18.51 +/- 0.17 ng/mL in patients aged 0-15 years (n=3,219), 11.86 +/- 0.12 ng/mL in patients aged 16-30 years (n=4,093), between 31-45 years old 12.12 +/- 0.14 ng/mL in patients (n=3,008), 12.39 +/- 0.18 ng/mL in patients aged 46-60 years (n=1,817), and 13.40 +/- 0.28ng/mL in patients aged 61-75 years (n=962).Conclusion: In this study, very serious vitamin D deficiency was detected in patients admitted to Cizre State Hospital. It is thought that low vitamin D levels may be related to the absence of vitamin D synthesis because of insufficient sunlight in winter, the closed dressing habits of the region, or foods deficient in vitamin D. Because of this study, the need for supportive treatment gained more importance.Öğe Changes in Vitamin D Levels According to Age, Gender and Season in the Siirt Province(Galenos Yayincilik, 2020) Alayunt, Naci Omer; Ozudogru, OsmanObjective: This study aims to determine the 25-hydroxyvitamin D [25(OH)DI profile of the region based on season, age and gender by examining the vitamin D levels of patients who applied to the Siirt Training and Research Hospital from Siirt and neighbouring provinces. Materials and Methods: (25(OH)DJ levels were analysed retrospectively in patients who applied to Siirt Training and Research Hospital. The study included 31,151 patients who were admitted to the hospital. Were included in the study. (25(OH)DJ levels were determined according to the age and gender of patients and the seasons of the year. A serum [25(OH)D] level <12 ng/mL was considered as serious deficiency, 12-20 ng/mL mild-to-moderate deficiency, 21-30 ng/mL insufficiency, >30 ng/mL sufficiency. Results: The average (25(OH)DJ level in patients aged 0-15 years (n=6,166) was 20.59 +/- 0.14 ng/mL, in patients aged 16-30 years (n=10,791) it was 15.65 +/- 0.10 ng/mL, in patients aged 31-45 years (n=6,649) it was 16.28 +/- 0.14 ng/mL, in patients aged 46-60 years (n=4,120) it was 16.83 +/- 0.23 ng/mL and in patients ages 61-75 years (n=2,597) it was 16.03 +/- 0.15 ng/mL. Conclusion: It has been observed that [25(OH)D] level, which is low in winter and spring, is high in summer and autumn when it is exposed to the intense rays of the sun. However, this level is lower than the desired levels in all four seasons. This low level of vitamin D may be related to the absence of almost any vitamin D synthesis in winter and inadequate vitamin D intake associated with foods.Öğe Effect of omega-3 fatty acid on contrast-induced nephropathy(State Institution Institute of Nephrology of the National Academy of Medical Science of Ukraine, 2021) Bolatli, Gunes; Ulusoy, Mahinur; Tas, Fatih; Alayunt, Naci Omer; Zarasiz, IsmailRenal failure that develops acutely after the use of iodinated contrast material is called “contrast-induced nephropathy”. It is a complication with high morbidity and mortality risk. Current treatments are aimed at protecting kidney functions, new treatment methods are being researched. This study aims to demonstrate the therapeutic effects of omega-3 fatty acids on CIN, taking into account the possible clinical usage of iodinated contrast media and the benefits of omega-3 fatty acids. Methods. A total of 30 rats were studied, divided into four groups. Only saline was administered by gavage to group 1, only IV urography to group 2, only 400 mg omega-3 to group 3, and urography and 400 mg omega-3 to group 4. At the end of the study, kidney tissue and serum oxidative and antioxidant markers, and creatinine levels were analyzed. Result. While the degrees of glutathione peroxidase, catalase and total antioxidant capacity in kidney tissue and serum tests of rats treated with omega-3 fatty acid increased statistically; total oxidant capacity and malondialdehyde levels were found to be significantly lower. Furthermore, blood urea nitrogen and creatinine levels were found to be significantly lower in the omega-3 treated group. Conclusion. Omega-3 fatty acids had therapeutic effects in the experimental CIN model. As a result, we believe omega-3 fatty acids can be used as an alternative to existing supportive medicines in this common disease with few therapy options. © G. Bolatli, M. Ulusoy, F. Tas, N. O. Alayunt, I. Zarasiz, 2021. All rights reserved.Öğe Effects of Thymus vulgaris Oil on Sodium Hypochlorite-Induced Damage in Rats(Mdpi, 2023) Bolatli, Guenes; Tas, Fatih; Alayunt, Naci OmerWe aimed to determine the potential damage mechanisms of exposure to widely used sodium hypochlorite (NaOCl) and the effects of Thymus vulgaris on this exposure. Rats were divided into six groups: control, T. vulgaris, 4% NaOCl, 4% NaOCl + T. vulgaris, 15% NaOCl, and 15% NaOCl + T. vulgaris. Serum and lung tissue samples were taken after applying NaOCl and T. vulgaris by inhalation twice a day for 30 min for four weeks. The samples were examined biochemically (TAS/TOS), histopathologically, and immunohistochemically (TNF-alpha). In serum TOS values, the mean of 15% NaOCl was significantly higher than in 15% NaOCl + T. vulgaris. This was the opposite in terms of serum TAS values. Histopathologically, there was a significant increase in lung injury in 15% NaOCl; significant improvement was observed in 15% NaOCl + T. vulgaris. Immunohistochemically, there was a significant increase in TNF-alpha expression in both 4% NaOCl and 15% NaOCl; significant decreases were observed in both 4% NaOCl + T. vulgaris and 15% NaOCl + T. vulgaris. The use of sodium hypochlorite, which is harmful to the lungs and is widely used in homes and industries, should be limited. In addition, using T. vulgaris essential oil by inhalation may protect against the harmful effects of sodium hypochlorite.Öğe Evaluation of some biochemical parameters of pediatric patients hospitalized for rotavirus in Şırnak Province: A retrospective review(2023) Sonmez, Erhan; Tahiroglu, Veysel; Coskun, Erkam; Alayunt, Naci OmerRotavirus gastroenteritis is an important cause of worldwide morbidity and mortality in infants and children. The main cause of mortality is dehydration due to fluid loss and malnutrition. This study aims to examine the guiding parameters of uric acid and creatinine levels in the detection of dehydration and fluid deficit and inpatient management in cases of rotavirus gastroenteritis. Children who applied to Şırnak State Hospital, Pediatrics Polyclinics, children (6 months-18 years old) whose faecal samples were sent to the laboratory by the research pediatrician considering the diagnosis of rotavirus and whose microbiological examinations were confirmed by immunochromatographic methods (6 months-18 years old), were included in the study by scanning the system. When positive patients were evaluated, the mean age for serum uric acid was 1.06±1.53 and the mean age for serum creatinine was 1.10±1.37. The median value was 3.75 mg/dL in negative patients with serum uric acid levels, and 5.25 mg/dL in positive patients, which was statistically significant (p<0.01). The median value of serum creatinine level was 0.41 mg/dL in negative patients and 0.43 mg/dL in positive patients, which was statistically significant (p<0.05). With this study carried out in Şırnak province, we think that children in the region are severely affected by the rotavirus and face severe dehydration. Therefore, we think that all parameters affected by rotavirus should be evaluated according to regions and parents should be educated about the importance of rotavirus vaccine in the prevention of rotavirus gastroenteritis.Öğe Folate, Vitamin B12 and Serum Ferritin Levels by Age and Gender in Children Presenting with Protein and Energy Insufficiency: A Retrospective Review(Istanbul Univ, 2023) Tahiroglu, Veysel; Coskun, Erkam; Sonmez, Erhan; Alayunt, Naci OmerObjectives: The aim of this study is to determine the levels of folate, vitamin B12, and ferritin according to gender and age groups in children who visited the hospital with the complaint of protein and energy deficiency. Methods: Folate levels of 74 patients with protein and energy deficiency complaints, vitamin B12 levels of 184 patients, and ferritin levels of 187 people who were admitted to the hospital were included in the study. The hospital reference ranges for children were used to diagnose folate, vitamin B12, and ferritin levels and to determine their normal ranges. Results: When the folate levels were examined in the study, it was determined that approximately 2% of the children in the 0-6 age group were below <3.89 ng/mL, and all of the children in the 7-18 age group were within the normal range. When the vitamin B12 levels are examined, it was determined that 3.3% of the children had a vitamin B12 level below 191 ng/L, and 14.3% of the 7-18 age group were below 191 ng/L. Considering the ferritin levels, it was determined that 51.6% of the children were below 30 mu g/L. When evaluated according to gender, the majority of folate and B12 levels in both men and women were within the normal range, while 47.1% of women and 41% of men had ferritin levels below the normal range. Conclusion: It was observed that the folate, vitamin B12, and ferritin levels of the patients could vary according to geographical regions. For this reason, we think that it should be focused on the 0-6 age range, where the incidence of micronutrient deficiencies and infectious diseases is the highestÖğe Hepatoprotective effects of safranal on acetaminophen-induced hepatotoxicity in rats(De Gruyter Poland Sp Z O O, 2024) Alayunt, Naci Omer; Parlak, Akif Evren; Turkoglu, Semra; Tas, FatihThis research aimed to explore the protective and therapeutic properties of safranal in mitigating inflammation and oxidative stress induced by elevated acetaminophen (APAP) doses in a rat model. The protective and therapeutic effects of safranal were determined by histopathologically and examining some biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), glutathione, glutathione peroxidase, catalase, malondialdehyde, interleukin-6, tumor necrosis factor-alpha, and interleukin-1 beta. Male Wistar-Albino rats were subject to random allocation, forming five groups, each comprising seven rats (n = 7) in the study. Group 1 was the control group. APAP was administered in Group 2 to induce hepatotoxicity. Rats in Groups 3, 4, and 5 received intraperitoneal injections of safranal at doses of 0.025, 0.05, and 0.1 mL/kg/day for 14 days, respectively. On the 15th day, to induce APAP-induced hepatotoxicity, four groups (Groups 2, 3, 4, and 5) acquired a single intraperitoneal injection of 600 mg/kg APAP. The presence of APAP-induced hepatotoxic effect was proven by elevated AST and ALT levels, which are typical biomarkers of liver function in addition to the demonstration of histopathological changes. The findings suggest that pre-treatment with safranal may offer a protective effect against hepatotoxicity by attenuating oxidative stress and the inflammatory response.Öğe Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters(2020) Alayunt, Naci Omer; Üstündağ, BilalThe high level of fructose taken in the diet is one of the reasons for the increased prevalence of metabolic syndrome,which is increasing day by day globally in association with the effects of genetic and environmental factors. In thestudy, 21 male Sprague-Dawley rats of 220±20 gr body weight were used. The rats were assigned to 3 groups as thecontrol group, metabolic syndrome group, and the group where Nigella sativa oil was administered. The serum homocysteine levels were increased in the metabolic syndrome group compared to the control group but without statisticalsignificance (p>0.05). Homocysteine levels decreased significantly after Nigella sativa oil compared to metabolicsyndrome group. LDH (p <0.001) and uric acid (p <0.05) levels which were higher in metabolic syndrome groupwere decreased in Nigella sativa oil group. Hyperhomocysteinemia is a risk factor for endothelial dysfunction. In ourstudy, the treatment of the metabolic syndrome and regulation of the increased levels of homocysteine with Nigellasativa oil in metabolic syndrome were discussed. Some biochemical parameters and improvements in homocysteinelevels with Nigella sativa oil has been identified. In this study, we have concluded that the occurrence of elevated levels of plasma homocysteine are closely associated with the development of inflammation, cellular adhesion, hepaticdysfunction, and cell proliferation and that the reduction in the serum levels of homocysteine by the administrationof Nigella sativa oil will lead to favorable out comes.Öğe Integrating the in vitro antioxidant activity of Polyacrylonitrile/Polyindole composites(Wiley, 2024) Alayunt, Naci Omer; Soykan, CengizIn this study, five compounds belonging to the Polymer composites (PCs) family, have been prepared with different amounts of polyacrylonitrile and polyindole in the composite. The PCs have inherently bactericidal activity, owing to the nitrile and indole groups. Antioxidant activity was assessed by using reducing power activity, superoxide radical scavenging activity and hydroxyl radical scavenging activity. In our study, butylated hydroxy toluene (BHT), ascorbic acid and alpha-tocopherol, which are considered synthetic standard antioxidants, were used to compare antioxidant activity. In addition, since it is known that the MDA levels resulting from the oxidation of fats in Saccharomyces cerevisiae yeast cells are inversely proportional to the antioxidant properties, it gave an idea about the in vitro antioxidant properties of the new synthesized PCs. Reducing force capacity, superoxide radical scavenging activity and hydroxyl radical scavenging activity were found to be higher at 100 mu g mL-1 concentration compared to 50 mu g mL-1 concentration. Integrating the In-Vitro Antioxidant Activity of Polyacrylonitrile/Polyindole Composites. imageÖğe Protective role of BDNF in Alzheimer's disease pathophysiology and its correlation with new biomarkers: Can the role of BDNF be re-discussed?(Wroclaw Medical Univ, 2024) Tahiroglu, Veysel; Ugur, Elif; Coskun, Erkam; Alayunt, Naci Omer; Zorgor, GulsahBackground. The pathophysiology of Alzheimer's disease (AD) is not fully understood and that new biomarkers for the condition should be presented. Objectives. Our study aimed to determine the blood levels of some biochemical molecules and peptide proteins in AD, which is accepted as the most common cause of dementia in the world, and to elucidate the relationship between them.Materials and methods. The study consisted of 2 groups: 40 newly diagnosed AD patients and 40 healthy individuals. Plasma levels between the 2 groups and the correlation between them were statistically analyzed.Results. The median brain-derived neurotrophic factor (BDNF) level in the AD group was found to be higher and statistically significant compared to the control group (p = 0.033).Conclusions. According to our literature review, this is the first article in which these molecules have been studied together in AD patients. In this study, we revealed the importance of these parameters and especially the instrumental role of BDNF in the form and function of the brain in AD patients. Interestingly, in the patient group, all parameters in our study showed a positive and significant positive relationship with one another (p < 0.001).Öğe Psychological and biochemical Impact of Covid-19 pandemic on health workers in Siirt, Turkey(2021) Alayunt, Naci Omer; Özüdoğru, Osman; Cakan, ErgulThe aim of this study was to analyze the anxiety level of health care workers at the forefront of the fight against Covid-19 and to determine the prevalence of psychiatric symptoms of factors contributing to psychological stress and to identify risks and preservatives. To determine the anxiety levels of healthcare workers and the factors that contribute to psychological stress in the fight against Covid-19. After receiving ethical and legal permissions Necessary Siirt, a total of 150 people working in training and Research Hospital Covid-19 pandemic pandemic 50 to 100 active employee in the service of medical personnel and medical personnel outside the service running status among sociodemographic trait anxiety (Beck anxiety scale and the impact of Event Scale), a survey study was conducted with the questions the reasons. In this study, the effect scores of events in the pandemic service were found to be different at p<0.001 level compared to non-pandemic. At the same time, anxiety scores in the pandemic service were found to be different at the level of p<0.001 compared to non-pandemic. It was consistent with previous studies on the biochemical findings of healthcare workers who contracted Covid-19. In this context, administrators' attentive behavior towards psychological, psychological and psycho-social needs, stabilization of anxiety, and programs that teach relaxation techniques can help healthcare professionals develop self-help skills during periods of increased stress.Öğe Synthesis, spectroscopic characterization, and in vitro antioxidant activity of polyglycidylmethacrylate/polyindole conducting polymer composites(Wiley, 2021) Alayunt, Naci Omer; Soykan, CengizPolyglycidylmethacrylate/polyindole (PGMA/PIN) conducting polymer composites having five different compositions were prepared chemically using FeCl(3)as an oxidant agent in chloroform solution and nitrogen atmosphere at 10 degrees C. The conducting polymer composites were characterized by FTIR spectroscopic technique, scanning electron microscopy (SEM), atomic force microscopy (AFM), and thermogravimetric analysis (TGA) measurements. It is seen that morphological structure of composite is different from PIN and PGMA. PGMA/PIN conducting polymer composite including 50% of PIN has a nonuniform and less homogenous structure compared to the PIN and PGMA polymer. in vitro antioxidant activity such as reduction force, superoxide radical removal activity, hydroxyl radical trapping activity, MDA measurements inSaccharomyces cerevisiaecells of PGMA/PIN conducting polymer composite was investigated. It was observed that the reduction force capacities decreased as PIN content and increased due to the percentage of composite of PGMA content. in vitro studies of synthesized composites have shown us that these compounds possess new antioxidant properties.Öğe Total secondary metabolites and heavy metal profile of some medicinal plants frequently consumed as winter tea(2023) Karagözoğlu, Yusuf; Alayunt, Naci Omer; Parlak, Akif EvrenIn this study, sage (Salvia officinalis L.), linden (Tilia platyphyllos Scop.), and daisy (Matricaria chamomilla L.) herbs, which have rich phytochemical content and are frequently consumed in winter months for medicinal purposes, were obtained from three different herbalists located in Bingol and investigated in terms of their heavy metal contents, total flavonoid, total anthocyanin and total polyphenol contents. Some of the heavy metal (Cr, Fe, Co, Ni, Cu, Zn, As, Hg, Pb) contents of the collected herb samples were determined by ICP-MS. Total flavonoid, total anthocyanin and total polyphenol contents were determined by analyzing spectrophotometric methods. While the total phenolic content was found the most in sage (S1) ethylacetate and methanol extracts (760.1±2.0, 410.33±1.5 mg GAE/g), it was found the least in linden (L1, L3) hexane extracts (6.66±.1.3, 8.35±0.8 mg GAE/g). It was determined that total flavonoid content and total anthocyanin contents were higher in sage (S1) ethylacetate (294.31±2.1 mg CE/g and 291.31±2.1 mg MvGE/g), sage (S2) methanol (375.0±1.9 mg CE/g and 139.01*±2.0 mg MvGE/g) extracts, and less in linden (L1) and daisy (D1) hexane extracts respectively. It was determined that Cr and Cu metals were among the values suitable for consumption in terms of health in all samples except the chamomile (D1, D3) samples, and Zn metals were among the values suitable for consumption in all samples except the linden (L2) sample. Furthermore, the toxic metal Cd (0.05±0.00- 0.09±0.00 ?g/g) in daisy (D1, D3) samples, as well as the other toxic metal Pb (4.50±0.01-6.43±0.01 ?g/g) in sage (S1,S2,S3) and linden (L1,L2,L3) samples, were found to be among the values suitable for consumption in terms of health. As a result, when the total anthocyanin, polyphenol and flavonoid contents were compared in all groups it was found that sage had the highest value in ethyl acetate extract. Additionally, Cu and Ni values of sage, and Fe and Pb values in both sage and linden were within safe limits in terms of health. They are of utmost importance in terms of supporting the daily mineral intake. However, As, Pb, and Hg were found to be toxic in daisy extract. This result can be shown as a result that the daisy will be a bioaccumulator. Therefore, consumption of daisy tea should be limited.
