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    Acquired Skin Fragility Syndrome in a Juvenile Cat Following a Routine Ovariohysterectomy
    (Univ Fed Rio Grande Do Sul, 2021) Bilen, Ebru Karakaya; Akgul, Mustafa Baris
    Background: Acquired skin fragility syndrome (ASFS) is a rare condition, which is characterized by spontaneous fragility of the skin and an absence of hyperextensibility. Even though the real pathogenesis of ASFS remains unknown that is reported generally with some iatrogenic causes and severe diseases. Thus, based on the clinical findings this is the first report of describes the case and treatment of feline acquired skin fragility syndrome following a routine ovariohysterectomy. Case: An 8-month-old domestic shorthair female cat was brought to the Siirt University Animal Health Application and Research Center for ovariohysterectomy operation. Before the operation physical examination of the animal revealed body temperature, heart rate, respiratory rate, the color of mucosas, and lymph nodes were determined normally. Besides, there is no hematological and biochemical problem detected. The cat had no previous history of several infections or systemic disease. A routine ovariohysterectomy procedure was applied under general anesthesia and the cat was discharged on the same day. Three days after that a spontaneously developed cutaneous laceration below the left scapular region was determined by the cat owner. During the clinical examination, it was determined that the cat was sensitive to touch against the left scapular area. Multiple spontaneous skin tear was revealed over the left scapular region while shaving for better inspection but did not obtain any problem with incision line. To identify the underlying cause of skin tearing, hematological and biochemical tests were done but the animal's results were found within the normal references. Also, rapid blood tests were performed for feline leukemia virus and immunodeficiency virus, and none of them were positive. Additionally, the skin was not hyperextensible. Although the clinicopathological abnormalities were observed on the skin, there were no abnormalities in the vital signs of the cat. Based on the clinical status of the cat, daily regular wound cleaning and a wet-to-dry bandage were applied for two weeks. Skin therapy based on the use of dexpanthenol, vitamin E, and vitamin C with zinc was preferred to improve skin health. All lesions on the skin of the cat completely recovered and a follow-up visit for several weeks was recommended to the cat owner. Discussion: There have been reports that acquired skin fragility syndrome may be related to hepatic diseases, some feline viral infections, hyperadrenocorticism, or use of a long time progestational drugs. Also, acquired skin fragility syndrome can be seen in a congenital disorder known as cutaneous asthenia which is described generally in young cats. Cutaneous asthenia and acquired skin fragility syndrome are difficult to distinguish from each other even though histological examination was made. Although the cat in this report is young, there was no history of skin problems and skin hyperextensible until presentation. No specific treatment protocol described for this skin problem has been reported. Moreover, vitamins and minerals may be used for wound treatment and strengthening the skin. Ovariohysterectomy is the most common surgical technique used for sterilization of cats however; it can cause some complications, such as acute stress. Unfortunately, the exact etiology is not detected in this case report but it is thought to be that stress of ovariohysterectomy might be triggered to spontaneous skin tearing.
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    Effect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats
    (Routledge Journals, Taylor & Francis Ltd, 2021) Ozcan-Sinir, Gulsah; Inan, Sevda; Suna, Senem; Tamer, Canan Ece; Akgul, Mustafa Baris; Bagdas, Deniz; Sonmez, Gursel
    Increased risk of pancreatic cancer may be associated with consumption of sugar containing foods. The aim of this study was to evaluate the effect of peach nectar containing high fructose corn sirup (HFCS) consumption in a pancreatic carcinogenesis rat model induced by 7,12-Dimethyl benzanthracene (DMBA). Fifty-day-old male Sprague Dawley rats were fed with peach nectar containing HFCS + chow, peach nectar containing sucrose + chow and only chow. After 8 mo, feeding period, each group was divided into two subgroups, in which the rats were implanted with DMBA and no DMBA (sham). Histologic specimens were evaluated according to the routine tissue processing protocol. The animals withad libitumaccess to pn-HFCS, pn-sucrose and chow (only) showed significant differences in chow consumption and glucose level. Necropsy and histopathologic findings showed tumor formation in the entire group treated with DMBA. Excluding one rat in chow group, which was classified as poorly differentiated type, the others were classified as moderately differentiated pancreatic ductal adenocarcinoma (PDAC). This study demonstrated that daily intake of HFCS did not increase body weight and there was no effect of peach nectar consumption on the development of PDAC induced by DMBA in rats.
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    TROPONIN-1, CK-MB, D-DIMER, AND NT-proBNP LEVELS BEFORE AND AFTER TWO DIFFERENT ANESTHESIA PROTOCOLS IN DOG
    (Assiut University, Faculty of Veterinary Medicine, 2023) Akgul, Gülsah; Akgul, Mustafa Baris; Gulendag, Erman; Basak, Mahsum; Kilic, Sevdet
    This study aimed to determine the cardiac effects of two different anesthetic protocols by measuring serum levels of Troponin 1, CK-MB, NT-proBNP and D-Dimer in healthy castrated non cardiac dogs. Thirty adult, healthy, and noncardiac male dogs were brought to the animal hospital affiliated to the Animal Health Application and Research Center of Siirt University for castration. The animals were sedated with intramuscular administration of 2 mg/kg of xylazine HCl and anesthesia was induced by intramuscular administration of 10 mg/kg Ketamine HCl. The animals were intubated and connected to the closed-circuit anesthesia device. Following induction of general anesthesia, dogs were divided into two groups. Group 1 (G1) (n=15) was administered with 2-3% Isoflurane inhaler, the other group (G2) (n=15) was administered with 2-3% Sevoflurane inhaler to maintain anesthesia. Blood samples were collected before and 12 hours after anesthesia. Results revealed non-significant changes in serum levels of CK-MB over time. However, a significant difference was observed in CK-MB values between sevoflurane and isoflurane. No significant changes in Troponin values were recorded. Significant changes in Nt-Pro BNP values over time were observed, but the changes were not significant between anesthetic protocols. With the present study, we can partially say that sevoflurane is safer than isoflurane, but we believe that more studies should be done with more samples. © 2023, Assiut University, Faculty of Veterinary Medicine. All rights reserved.