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Öğe Antimicrobial Activity of Phytic Acid, Citric Acid, and EDTA with and without Propolis against Enterococcus Faecalis and Candida Albicans(Mashhad University of Medical Sciences, 2022) Yeniçeri Özata, Merve; Acer, Ömer; Demirci, Özlem; Çolak, Mehmet; Akın Tartuk, GizemIntroduction: This study aimed to investigate the antimicrobial efficacy of chelation agents on Enterococcus faecalis (E. faecalis) and Candida albicans (C. albicans) when used alone or in combination with propolis. Methods: One hundred fifty mandibular premolar teeth were selected. Each canal was prepared with Reciproc R25. The roots were then divided into two parts along their long axis (n=300). For E. faecalis and C. albicans, the samples were divided into 16 groups (14 experimental and 2 control) as follows: Group 1A-1B [17% Ethylenediaminetetraacetic acid (EDTA)], Group 2A-2B [10% Citric Acid (CA)], Group 3A-3B [1% phytic acid/inositol hexaphosphate (IP6)], Group 4A-4B (17% EDTA+8 mg/mL propolis), Group 5A-5B (10% CA+8 mg/mL propolis), Group 6A-6B (1% IP6+8mg/mL propolis), Group 7A-7B (8 mg/mL propolis), Control A-B (Dimethyl Sulfoxide). Each tooth was randomly irrigated with 2 mL of one of the group solutions or dispersions for 5 min, and the solutions were examined for the bactericidal effect. Results: For C. albicans, all groups showed less optical density (OD) than the control group (P<0.05). The propolis group and the IP6 group had higher OD values than the CA group (P<0.05). For E. faecalis, on the other hand, significantly lower OD values were observed in the propolis+ CA group, compared to the CA and propolis groups (P<0.05). There was no significant difference between microbial growth among IP6, EDTA, propolis+ CA, propolis+IP6, and propolis+ EDTA groups (P>0.05). Conclusion: CA and IP6 showed promising results in eliminating E. faecalis, one of the collective organisms responsible for failed root canals. © 2022, Mashhad University of Medical Sciences. All rights reserved.Öğe Effectiveness of inactivated and mRNA COVID-19 vaccines on sperm parameters(2024) Afşin, Muhamet; Acer, Ömer; Yavuz, DilekObjective: The mRNA SARS-CoV-2 vaccine has been shown to have no adverse effects on semen parameters. However, it is yet unknown whether the inactivated vaccinations have the same effect. Thus, our objective was to evaluate the parameters of sperm prior and following the administration of mRNA and inactivated COVID-19 vaccinations. Methods: In this study, the sperm quality was evaluated both before and after receiving the COVID-19 mRNA and inactivated vaccines. Of the participants, 28 received two doses of CoronaVac vaccine and 152 received two doses of mRNA BNT162b2 mRNA vaccine (Pfizer-BioNTech). Semen analyses were repeated 72 (57-145) days after the same individuals had received their second dose of COVID-19 vaccination. Results: No significant differences were found in the parameters of sperm before and after administration of two doses of BNT162b2 vaccine. Prior to and following administration of the two doses of the inactivated vaccine, there was no appreciable variation in the volume of semen, sperm concentration, progressive motility, total motility, immotility, or morphologically normal sperm features. Following CoronaVac vaccination before and after two doses, only the total sperm count was shown to statistically decrease (p=0.03). Conclusion: As a result, while there was no significant difference in the sperm parameters of the mRNA vaccine, it was determined that there was a statistical decrease in the total sperm count before and after two doses of CoronaVac vaccine. Since the semen volume of all patients is within normal limits, the first issue to be used here as a number is sperm per ml, which is important in terms of infertility, is the number.Öğe Investigation of the Presence of mecA and mecC Genes and Antibiotic Resistance Profiles in Methicillin-Resistant Staphylococcus aureus Strains Isolated from Clinical Samples(2024) Erdoğan, Mustafa; Acer, Ömer; İnal, BehçetObjective: Methicillin-resistant Staphylococcus aureus (MRSA) is widely regarded as one of the most frequent bacteria, causing a wide range of infections in humans and animals. MRSA is associated with significant morbidity and mortality in many parts of the world. The aim of this study was to determine the molecular identification, antibiotic resistance profiles, and presence of mecA and mecC genes of MRSA strains isolated from clinical specimens at Siirt Training and Research Hospital. Methods: In our study, we isolated 20 coagulase positive S. aureus strains from patients admitted to our hospital between July 2020-July 2021. Antibiotic susceptibility tests were carried out on the bacteria that were isolated and identified by culturing various clinical samples. The mecA and mecC genes were then examined by polymerase chain reaction (PCR) using the universal primers mecA-F-mecA-R and mecC-F-mecC-R following MRSA had been identified in the cultures from the clinical samples. To identify the isolated S. aureus strains by 16S ribosomal ribonucleic acid (rRNA) gene analysis, polymerase chain reaction (PCR) amplification was conducted using universal primers 68f and 518r. Results: We isolated and identified 20 coagulase positive S. aureus strains from patients admitted to our hospital. According to the 16S rRNA gene sequences, the strains isolated in this this study, exhibited high similarity (99%-100%) to the 16S rRNA genes of S. aureus strains listed in GenBank (https ://ww w.ncb i.nlm .nih. gov/g enban k/). While the mecA gene was found in 18 of 20 strains, none of the strains had the mecC gene. A high percentage of MRSA was found to be penicillin resistant (75%). In conclusion, 20 MRSA strains were isolated from various clinical specimens. Eighteen of these strains were also identified molecularly by 16S rRNA sequence analysis. Conclusion: The results of this study confirmed the significance of the 16S rRNA, mecA, and mecC genes in MRSA identification and highlighted the increasing frequency of MRSA in TürkiyeÖğe Seropositivity of HBsAg, Anti-HBs, Anti-HCV and Anti-HIV in patients admitted to Siirt Training and Research Hospital(2022) Acer, Ömer; Özüdoğru, OsmanABSTRACT Objective: Viral hepatitis infections, including hepatitis B and C, and HIV represent an important public health problem worldwide. In this study, we aimed to investigate the seropositivity of HBsAg, Anti-HBs, Anti-HCV, and Anti-HIV in patients who applied to our hospital between 2019 and 2021. Methods: In this study, the frequency of HBsAg, Anti-HBs, total Anti-HCV and anti-HIV in patients admitted to our hospital between January-2019-January 2021 was evaluated retrospectively. Results: HBsAg positivity was determined as 3.28% in a total of 52420 patients. HBsAg positivity was found to be 4.12% (95%CI: 3.9-4.3) in males, whereas 2.67% (95%CI 2.56-2.78) in females. There was a statistically significant relationship between HBsAg positivity and gender and age (p<0.001). Anti-HBs level of 54.9% of the patients (95%CI: 44.6-45.6) was found to be sufficient for immunity (Anti-HBs >10 mIU / ml). While this rate was found to be 61.04% (95%CI: 60.5-61.5) in males, it was found to be 50.37% (95%CI: 50-50.7) in females. A significant relationship was found between Anti-HBs positivity and gender and age (p<0.001). General Anti-HCV positivity was found as 0.11% (95%CI: 0.09-1.01). There was significant relationship between age groups for anti-HCV positivity (p<0.001), whereas the relationship for gender was not significant (p=0.934). There was no statistically significant relationship between anti-HIV positivity and age (p=0.307) and gender (p=0.999). Anti-HIV positivity was determined as 0.3‰ (95%CI: 0.01-1.05). Conclusion: As a result, viral hepatitis is an important health problem around the world and for our city. Vaccination, infection control programs, and public education can reduce the risk of new infections. Anti-HIV positivity was found to be very low in our city.
