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  • [ X ]
    Öğe
    Abdominal sakroservikopeksi operasyonunun yaşam kalitesi ve cinsel sağlık skorları üzerine etkisi
    (2023) Aksin, Şerif; Balsak, Deniz; Yılmaz, Mehmet; Aboalhasan, Yasmin
    Amaç: Pelvik organ prolapsusu (POP) cerrahisinde çeşitli yöntemler kullanılmaktadır. Bu yöntemlerden biri olan abdominal sakroservikopeksi başarı oranları bilinmesine rağmen yaşam kalitesi ile ilgili veriler yetersizdir. Çalışmamızın amacı abdominal sakroservikopeksi operasyonunun yaşam kalitesi ve cinsel sağlık ile ilgili sonuçlarını araştırmaktır. Yöntemler: Çalışmamız, Diyarbakır Gazi Yaşargil Eğitim ve Araştırma hastanesinde 01.05.2008 ile 31.12.2012 tarihleri arasında POP tanısı ile abdominal sacrocervicopexy operasyonu yapılan 72 hastayı içeren retrospektif kohort çalışmasıdır. Operasyon sonrası bu hastalar ortalama 29.68 ± 6.55 ( 20-49 ) ay takip edildiler. Hastalar, demografik, klinik operasyonel özellikler, cerrahi başarı oranları, vajinal semptom skoru, seksüel semptom skoru (FSFI), (POP Q) quality life skoru, komplikasyonlar, de novo şikayetler açısından değerlendirildi. Bulgular: Çalışmamızda yaş ortalaması 37.77 ± 9.18 yıl, parite 5.07 ± 1.83, operasyon süreleri 55.25 ± 8.55 ( 38-72 dk ) dakika idi. Hastaların hastanede kalış süresi 39.51 ± 7.03 ( 30-72) saati buldu. Mesh erezyonu hiçbir hastada saptanmadı. En sık görülen komplikasyonun sırt ağrısı olduğu izlendi.( %18,1 ). Ortalama 30 aylık bir izlem sonrası hastalarımızın vajinal semptom skorlarının ( p?0.001 ) ve seksüel semptom skorlarının ( p?0.001 ) belirgin derecede anlamlı bir şekilde düzeldiği sonucuna varılmıştır. Yine bu hastaların Prolaps ilişkili yaşam kalitesi (P-QoL) skorlarında anlamlı düzelme olduğu belirlendi. ( p?0.001 ) . Sonuç: Abdominal sakroservikopeksi; yaşam kalitesi, cinsel sağlık ve pelvik organ prolapsusu başarısı konusunda uygulanabilir, etkili ve güvenli bir cerrahi prosedürdür.
  • [ X ]
    Öğe
    Comparison of orexigenic and anorexigenic neuropeptide levels in hyperemesis gravidarum patients with normal pregnant women: A prospective cohort study
    (Lippincott Williams & Wilkins, 2024) Yilmaz, Mehmet; Aksin, Serif; Balsak, Deniz; Aboalhasan, Yasmin; Batmaz, Ibrahim
    Background: The aim of this study was to determine whether orexigenic neuropeptides, orexin and galanin, and anorexigenic neuropeptides, alpha-melanocyte-stimulating hormone (alpha-MSH) and cocaine- and amphetamine-regulated transcript (CART), are implicated in hyperemesis gravidarum (HG). Methods: Fifty pregnant women who had been diagnosed with HG between April 2022 and February 2023 at the Siirt University Faculty of Medicine Training and Research Hospital (tertiary center) were recruited for this study. An equal number of pregnant women without an HG diagnosis were included in the study as the control group. Participants' age, pregnancy history, medical history, thyroid function test results, complete blood count results, and electrolyte levels were recorded, and their orexin, galanin, alpha-MSH, and CART serum levels were analyzed using an enzyme-linked immunosorbent assay. Results: No statistically significant differences in orexigenic neuropeptides (orexin and galanin) were observed between the HG and control groups. A statistical difference was found between an anorexigenic neuropeptide (alpha-MSH) and the control group (P = .012). Based on a receiver operating characteristic analysis, the alpha-MSH parameter was statistically significant for distinguishing between participants with an HG diagnosis and those without, with a sensitivity of 63.6%, specificity of 65.9%, and cutoff value of 11769.3 pg/mL (P = .012, area under curve: 0.655). Based on the severity classification of ketonuria (ketonuria levels of +1 or +2 were classified as mild, whereas levels of +3 or +4 were classified as moderate to severe), the anorexigenic CART neuropeptide was found to be a statistically significant diagnostic indicator of severe ketonuria (P = .020). Conclusion: alpha-MSH and CART levels were found to be related in HG patients and in HG patients with severe ketonuria.
  • [ X ]
    Öğe
    Thyroid Function Tests and Thyroid Antibody Tests in Ectopic Pregnancies: A Prospective Cohort Study
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Aksin, Şerif; Yilmaz, Mehmet; Balsak, Deniz; Aboalhasan, Yasmin; Yoldaş, Adem; Batmaz, İbrahim
    Thyroid hormone levels have been observed to induce structural changes in different regions of the fallopian tube. This study aimed to investigate the impact of thyroid hormones on ectopic pregnancy. In pursuit of this objective, 31 patients with ectopic pregnancy were monitored at Siirt University Training and Research Hospital between July 2022 and December 2022. Additionally, a total of 31 patients with normal first-trimester pregnancies, matched for age, parity, and gestational week, were included in th e control group. Various parameters, including patient age, pregnancy history, medical history, treatment methods, clinical and demographic data, TSH, fT3, fT4, TT3, TT4, Thyroglobulin, Anti-thyroglobulin Antibody, TSH receptor antibody (TrAB), Anti-Peroxidase Antibody, Anti-Tyroglobulin Antibody, hemogram, biochemistry, CRP, and sedimentation values, were compared.Clinical Trials no: NCT05446012 Statistically significant differences were noted in Free T3 (p = 0.011) and thyroglobulin (p = 0.018) values bet ween the ectopic pregnancy and control groups. Subsequent ROC analysis was conducted for the significant parameters, determining the AUC (Lower and Upper Bound), sensitivity, specificity, and cut-off values for each parameter. Multivariate logistic regression analysis followed, wherein the "backward stepwise model" was applied to the Free T3 parameter. The apparent parameter indicating an increased risk in the disease was Free T3, with a 4.2-fold increase and a 95% CI of [1.3-13.5]. Lower Free T3 levels were associated with an elevated risk of ectopic pregnancy. The assessment of Free T3 levels during pre-pregnancy counseling may aid in identifying pregnant women at risk of ectopic pregnancy. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.