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Öğe Behavior, antioxidant, and metabolomics effects of Allium tuncelianum(Wiley, 2024) Abbak, Nigar; Nemutlu, Emirhan; Recber, Tuba; Gul, Asli San Dagli; Akkoyun, H. Turan; Akkoyun, Mahire Bayramoglu; Yilmaz, GulderenAllium species are consumed extensively as folkloric medicine and dietary elements, but limited studies have been conducted on them. In this study, the effects of an ethanol-water extract obtained from the underground bulb of Allium tuncelianum (Kollmann) ozhatay, B. Mathew & Siraneci (AT) on the behavioral, antioxidant, and metabolite parameters in rats were evaluated. AT was administered orally once a day at doses of 100 and 400 mg/kg to male Wistar albino rats for 10 consecutive days. The elevated plus maze, rotarod, and hotplate tests were used to examine anxiety-like behaviors, locomotor activities, and pain perception in the rats, respectively. Additionally, untargeted metabolomic analyses were performed on plasma samples and AT extracts using two orthogonal analytical platforms. The phenolic components, mainly fumaric acid, malic acid, vanillic acid, quercetin-3-arabinoside, hydrocinnamic acid, and gallocatechin, were determined in the extract. In addition, arbutin, salicylic acid, trehalose, and nicotinic acid were analyzed in the extract for the first time. The AT extract did not decrease the catalase, glutathione peroxidase, or superoxide dismutase levels; however, diazepam decreased some of those parameters significantly in the brain, liver, and kidney. Although both the AT and diazepam treatments resulted in an increase in anxiolytic-like effects compared to the control group, no significant differences were observed (p > .05). In the metabolomic analysis, significant changes were observed in the rats treated with AT and diazepam, and they caused significant changes in some metabolic pathways, including amino acid and fatty acid metabolism, compared to the control.Öğe Effect of Carvacrol on Biochemical and Behavioral Parameters in Acute Floride Administration(Wiley, 2023) Abbak, Nigar; Gul, Asli San Dagli; Gormus, Mustafa; Akkoyun, Hurrem Turan; Akkoyun, Mahire Bayramoglu; Arihan, Okan[Abstract Not Available]Öğe Effects of Subacute Carvacrol Administration on Behavioral and Oxidative Stress Parameters During NaF Exposure(Int Soc Fluoride Research, 2024) Abbak, Nigar; Dagli Gul, Asli San; Gormus, Mustafa; Akkoyun, Hurrem Turan; Akkoyun, Mahire Bayramoglu; Arihan, OkanPurpose: Fluoride is an element found in the earth's crust thatleachesinto drinking waterfrom sources where the rocks contain fluoride-rich minerals.Excessive fluoride exposure can lead to complications in various tissues and metabolism, particularly affectingdental and skeletal tissuesalongside others. This study aimedto examine the impact of carvacrol (CAR), one of the main active compounds in thyme, on behavior and oxidative stress in sodium fluoride (NaF)exposure.In the current study, the Open Field Test (OFT), Elevated Plus Maze (EPM),and Barnes Maze testswere used to examine anxiety-like behaviors and spatial memory. Methods: Herein, 32 male Balb/C mice were divided into four groups:the Controlgroup, CARgroup:20 mg/kgCARintraperitoneally ( i.p.), NaF group: 50 ppm NaF (in tap water), and NaF+CAR group: 50 ppm NaF (in tap water) + CAR 20 mg/kg i.p. The treatments continued for 14 days. At the end of the protocol, the OFT, EPM test, and Barnes Maze test were conducted. Oxidative stress parameters[superoxide dismutase (SOD),catalase (CAT),malondialdehyde (MDA)]were examined in the brain, kidney, and liver tissues. Results: The oxidative stress data indicated significant changes caused by the NaF and CAR. In the liver and kidneys, the enzyme activity values of SOD and CAT decreased significantly in the NaF group compared to the control and CAR groups, while in the brain, the CAT enzyme activity significantly decreased in the NaF group compared to control and CAR groups (p<0.05). Moreover, the levels of MDA, an importantmarker of lipid peroxidation, were significantly higher in the liver and brain tissues of the NaF group compared to the control group (p<0.05).The behavioral study results indicated no significant difference in the EPMtest but showed an increase in the number of rearingbehaviorsin the NaF group compared to the NaF+CAR group in the OFT, and a decrease in the grooming time in the NaF group compared to the CAR group (p<0.05). Conclusions: In the brain, kidney, and liver tissues, NaF exerted oxidative stress,as seen via the examined parameters (CAT, MDA, and SOD), while the CAR seemed to have an ameliorative effect against NaF-induced oxidative stress. The administration of NaF did not induce significant anxiety;on the contrary,the concomitant administration of NaF and CAR causedincreased anxiety-like behaviors compared tothe lone NaF exposure.